陈伟 - 同济大学

个人简介

临床主攻颅脑创伤、脑血管病的微创手术治疗以及神经重症患者的抢救与康复。科研上主要致力于颅脑损伤治疗新策略的探索和研究，研究的主要方向为颅脑创伤后中枢神经细胞间的Crosstalk对神经功能的保护作用。作为第一负责人主持国家自然科学基金面上项目（2项）、上海市科委（1项）、上海市浦东新区民生项目（2项）及江西省教育厅重点项目（1项）等多项课题的研究。 2015入选上海市 “浦东新区优秀青年医学人才”、2020年入选江西省“杰出青年基金”等多项人才培养计划

研究领域

颅脑创伤(TBI)、线粒体自噬(Mitophagy)、焦亡(Pyroptosis)、外泌体（Exosome）、隧道纳米管（TnTs）

近期论文

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以独立第一及共一作者所发表的文章(As First Author) Zou SF#, Chen W#, Ding H#, Duan J*, Jiang BX*, Feng JG*, et al. Involvement of autophagy in the protective effects of ginsenoside Rb1 in a rat model of traumatic brain injury. Eur J Drug Metab Ph. 2022; 47(6):869-877. He B#, Chen W#, Zheng P, et al. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding mir-195 in traumatic brain injury. Aging-US. 2021; 13(6):8127-8145.（中科院分区：2区） Chen W, Hong T, Feng JG, et al. Astrocytes-derived exosomes induce neuronal recovery after traumatic brain injury via delivering GJA1-20k. J Tissue Eng Regen Med. 2020; 14(3):412-423.（中科院分区：2区） Chen W#, He B#, Zheng P, et al. Astrocytic insulin-like growth factor-1 protect neurons against excitotoxicity. Front Cell Neurosci. 2019.:298. （中科院分区：2区） Chen W, Zhao L, Liu N, et al. Elevated expression of mir-302 cluster improves TBI by inhibiting phosphorylation of Cx43 via ERK signaling. J Chem Neuroanat. 2019; 99:1-8. He B#, Chen W#, Zheng P, et al. Micro-326 decreases tau phosphorylation and neuron apoptosis through inhibition of JNK signaling pathway by targeting VAV1 in Alzheimer,s disease. J Cell Physiol. 2020; 235(1): 480-493. （中科院分区：2区） Chen W#, He B#, Zheng P. Astrocytic IGF-1 prevents excitotoxic downregulation of ADAR1 in calcium dynamics. J Cell Biochem. 2019; 120(6):9097-9103. Chen W, Zheng P, Feng JG, et al. Upregulation of connexin43 is critical for irradiation induced neuroinflammation. CNS＆ Neurol Disorder-DR. 2018; 17(7):539-546. Chen W, Guo YJ, Tong WS, et al. Phosphorylation of connexin 43 induced by traumatic brain injury promotes exosome release. J Neurophysiol. 2018; 119(1):305-311. Chen W, Guo YJ, Tong WS, et al. Cx40 correated with oxidative stress in brains of TBI rats. Restor Neurol Neurosci. 2017; 35(2):217-224. Chen W, Feng JG, Tong WS. Phosphorylation of astrocytic Cx43 by ERK1/2 impairs BBB in acute cerebral ischemia. Cell Biosci. 2017; 7.:43. （中科院分区：2区） Chen W, Guo YJ, Tong WS, et al. Involvement of autophagy in Cx40 reduction in late phase of TBI in rats. Brain Res Bull. 2017; 131:100-106. Chen W, Guo YJ, Tong WS, et al. Involvement of Cx40 in the protective effects of ginsenoside Rb1 against TBI. Cell Mol Neurobiol. 2016; 36(7):1057-1065. （中科院分区：2区） Chen W, Guo YJ, Tong WS, et al. Protective effect of ginsenoside Rb1 on integrity of BBB following cerebral ischemia. Exp Brain Res. 2015; 233(10):2823-2831. 以通讯/共通讯作者发表的文章(As Corresponding Author) Zheng P#, Feng JG#, Zou SF*, Chen W*, et al. Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. Bioeng Transl Med. 2022; 7(1):e10249. （当年度中科院分区：1区/TOP期刊，IF:10.684） Feng JG#, Zou SF#, Chen W*, et al. Astrocyte-derived exosome-transported GJA1-20k attenuates traumatic brain injury induced cognitive impairments in rats.Chin Med J（Engl）. 2023; 136(7):880-882.（中科院分区：2区，卓越/三高T1期刊， IF:6.13 ,PMID:36728924） Ren DB#, Zheng P#, Zou SF#, Feng JG*, Zhong CL*, Chen W*, et al.GJA1-20k enhances mitochondria transfer from astrocytes to neurons via Cx43-TnTs after traumatic brain injury. Cell Mol Neurobiol. 2022; 42(6):1887-1895.（中科院分区：2区） Ren DB#, Zheng P#, Feng JG#, Zou SF*, Hong T*, Chen W*, et al. Overexpression of astrocytes-specific GJA1-20k enhances the viability and recovery of the neurons in a rat model of traumatic brain injury. ACS Chem Neurosci. 2020; 11(11):1643-1650. （中科院分区：2区） Zheng P, He B, Chen W*. Inhibition of micro-RNA103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulation BDNF. Cancer Cell Int. 2019.:109.