刘权焰 - 同济大学

研究领域

我目前重点研究集中在肝胆恶性肿瘤治疗效果的优化方案选择。同时，我的基础研究致力于发现HBV相关性肝癌发展的表观遗传分子机制。目前我已获得四个国家自然科学基金上面上项目的支持。

近期论文

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Guo T, Wang H, Liu P, Xiao Y, Wu P, Wang Y, Chen B, Zhao Q, Liu Z, Liu Q（通讯作者）. SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops. Cancer Res. 2018 Jul 15;78(14):3849-3864 Liu Q（通讯作者）. Upregulation of SNHG6 exhibits an oncogenic effect, regulating ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma. Cancer Letters. 2016 Oct 1. pii: S0304-3835(16)30590-0. doi: 10.1016/j.canlet.2016.09.034 Bi Y, Yu G, Liu Q（通讯作者）. Glucocorticoid-induced S-adenosylmethionine Enhances the IFN Signaling Pathway by Restoring STAT1 Methylation in Hepatitis B Virus Infected Cells. J Biol Chem. 2014 Sep 30. pii: jbc.M114.589689 Liu Q, Liu L, Zhao Y, Zhang J, Wang D, Chen J, He Y, Wu J, Zhang Z, Liu Z Hypoxia induces genomic DNA demethylation through the activation of HIF-1{alpha} and transcriptional up-regulation of MAT2A in hepatoma cells.Mol Cancer Ther; 2011; 10(6): 1113–23 PMID:21460102 Liu Q, Chen J, Liu L, Zhang J, Wang D, Ma L, He Y, Liu Y, Liu Z, Wu J.The X Protein of Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the Methionine Adenosyltransferase 2A Gene Expression and Reducing S-Adenosylmethionine Production. J Biol Chem. 2011 May 13;286(19):17168-80.