个人简介
以项目负责人获得国家自然科学基金省部级、局级等课题共20余项。荣获上海市五一劳动奖章，上海市卫健委优秀学科带头人计划（新百人），上海市科委浦江人才计划，同济大学“十佳医务青年”和上海市“十佳医技”工作者提名奖等荣誉称号。以主要完成人员获得科技进步奖5项，包括上海市康复医学科技奖二等奖，华夏医学科技奖二等奖，中华医学科技奖一等奖，上海医学科技奖一等奖，教育部高等学校科学研究优秀成果奖自然科学一等奖。主编检验医学著作2部，授权发明专利2项。
近五年负责课题
2019.1-2022.12 国家自然科学基金面上项目（81873975） ，57万
2021.1-2024.12 国家自然科学基金面上项目（82072362） ，55万
2015.1-2018.12 国家自然科学基金面上项目（81472179） ，75万
2022.7-2024.9 上海市促进市级医院临床技能与临床创新三年行动计划，40万
2020-2023 上海市公共卫生重点学科建设， 60万
2016-2018 上海市公共卫生重点学科建设， 110万
2015.8-2018.7 上海市科委产学研课题（15DZ1950708）， 40万
近期论文
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Xiao S, Li D（李冬）, Zhu HQ, Song MG, Pan XR, Jia PM, Peng LL, Dou AX, Chen GQ, Chen SJ, Chen Z, Tong JH. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc Natl Acad Sci USA, 2006, 103: 16448-16453. (并列第一)
Li D（李冬）, Beisswenger C, Herr C, Hellberg J, Han G, Zakharkina T, Wiewrodt R, Bohle RM, Lenhof HP, Bals R. Myeloid cell RelA/p65 promotes lung cancer proliferation through Wnt/β-catenin signaling in murine and human tumor cells. Oncogene. 2014,33(10):1239-1248.
Li D（李冬）, Beisswenger C, Herr C, Schmid RM, Gallo RL, Han G, Zakharkina T, Bals R. Expression of the antimicrobial peptide cathelicidin in myeloid cells is required for lung tumor growth. Oncogene. 2014 ，33(21):2709-16.
Wang X , Jiang CM, Wan HY, Wu JL, Quan WQ, Wu KY, Li D（李冬）. Neuroprotection Against Permanent Focal Cerebral Ischemia by Ginkgolides A and B Is Associated With Obstruction of the Mitochondrial Apoptotic Pathway Via Inhibition of c-Jun N-Terminal Kinase in Rats. Journal of Neuroscience Research ,2014, 92:232–242.
Chen Y, Pan L, Jiang M, Li D（李冬）, Jin L. Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy ofcurcumin both in vitro and in vivo. Drug Deliv. 2016;23(4):1383-92. (并列通讯)
Yang D, Quan W, Wu J, Ji X, Dai Y, Xiao W, Chew H, Sun Z, Li D（李冬）. The value of red blood cell distribution width in diagnosis of patients with colorectal cancer. Clin Chim Acta. 2018;479:98-102.
Shang A, Wang W, Gu C, Chen C, Zeng B, Yang Y, Ji P, Sun J, Wu J, Lu W, Sun Z, Li D. Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils. J Exp Clin Cancer Res. 2019 Sep 18;38(1):411.
Ji P, Zhou Y, Yang Y, Wu J, Zhou H, Quan W, Sun J, Yao Y, Shang A, Gu C, Zeng B, Firrman J, Xiao W, Bals R, Sun Z, Li D. Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling. Theranostics. 2019 Apr 12;9(8):2209-2223.
Shang A, Gu C, Wang W, Wang X, Sun J, Zeng B, Chen C, Chang W, Ping Y, Ji P, Wu J, Quan W, Yao Y, Zhou Y, Sun Z, Li D. Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis. Mol Cancer. 2020 Jul 27;19(1):117.
Sun J, Wang X, Liu W, Ji P, Shang A, Wu J, Zhou H, Quan W, Yao Y, Yang Y, Gu C, Sun Z, Goel A, Weng W, Li D. Novel evidence for retinoic acid-induced G (Rig-G) as a tumor suppressor by activating p53 signaling pathway in lung cancer. FASEB J. 2020 Sep;34(9):11900-11912.
Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression. Cell Commun Signal. 2020 Mar 30;18(1):52. IF=7.525
Ping Y, Huang J, Zhu J, Sun Z, Shang A, Chen C, Liu W, Li D（李冬）. Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m6A-modified long non-coding RNAs in lung adenocarcinoma. Clin Epigenetics. 2023 Apr 7;15(1):60.
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