个人简介
博士及博士后期间主要从事游离核酸在非侵袭性产前诊断、移植排斥和肿瘤诊断方面的研究。近年来主要从事感染性疾病的病毒分子进化与感染免疫方面的研究。已发表SCI论文27篇,主持国家自然基金面上项目1项、上海市科委课题1项、子课题2项和上海市市卫计委课题1项。
课题
国家自然科学基金,诺如病毒GII.4流行株衣壳蛋白分子进化机理的研究
上海市科学技术委员会,噬菌体展示技术在诺如病毒快速检测中的应用研究
上海市卫计委,噬菌体展示技术在诺如病毒快速诊断中的应用
上海市科学技术委员会,乙肝和梅毒等快速诊断试剂的质量对比研究(子课题负责)
上海市科学技术委员会,结核菌抗体诊断试剂盒在肺内外结核的临床再评价(子课题负责)
近期论文
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Leung TN, Zhang J, Lau TK, Hjelm NM, Lo YM. Maternal plasma fetal DNA as a marker for preterm labour. Lancet 1998;352:1904-5.
Zhang J, Tong KL, Li PK, Chan AY, Yeung CK, Pang CC, et al. Presence of donor- and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism. Clin Chem 1999;45:1741-6.
Lo YM, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 1999;64:218-24.
Lo YM, Lau TK, Zhang J, Leung TN, Chang AM, Hjelm NM, et al. Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21. Clin Chem 1999;45:1747-51.
Lo YM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction. Cancer Res 1999;59:3899-903.
Tang NL, Leung TN, Zhang J, Lau TK, Lo YM. Detection of fetal-derived paternally inherited X-chromosome polymorphisms in maternal plasma. Clin Chem 1999;45:2033-5.
Zhang J, Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CW, et al. Determination of fetal RhD status by maternal plasma DNA analysis. Ann N Y Acad Sci 2000;906:153-5.
Leung TN, Zhang J, Lau TK, Chan LY, Lo YM. Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin Chem 2001;47:137-9.
Chan KC, Zhang J(并列第一作者), Chan AT, Lei KI, Leung SF, Chan LY, et al. Molecular characterization of circulating EBV DNA in the plasma of nasopharyngeal carcinoma and lymphoma patients. Cancer Res 2003;63:2028-32.
Chan KC, Zhang J(并列第一作者), Hui AB, Wong N, Lau TK, Leung TN, et al. Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem 2004;50:88-92.
Shen Z, Wang G, Zhang WJ, Qian FX, Li Y, Zhang M, Gu SM, Wang MY, Lin F, Hu YW, Yuan ZH, Zhang J (通讯作者). Rotavirus infection and its genetic characterization in non-hospitalized adults with acute gastroenteritis in Shanghai, China. Archives of Virology, 2013, 158(8):1671-7.
Shen Z, Qian FX, Li Y, Hu YW, Yuan ZH, Zhang J (通讯作者). Novel Norovirus GII.4 Variant, Shanghai, China, 2012. Emerging Infectious Diseases, 2013, 19(8):1337-9.
Chen ZJ, Li X, Xu L, Guan WC, Cao YS, Hu YW, Zhang J (通讯作者). Host immunological response and factors associated with clinical outcome in patients with the novel influenza A H7N9 infection. Clinical Microbiology and Infection, 2014, 20(8):O493-500
Wang G, Shen Z, Qian FX, Li Y, Yuan ZH, Zhang J (通讯作者). Genetic diversity of sapovirus in non-hospitalized adults with sporadic cases of acute gastroenteritis in Shanghai, China. Journal of Clinical Virology, 2014, 59(4):250-4.
Zhang J, Shen Z, Zhu ZQ, Zhang WJ, Chen HF, Qian FX, Chen HL, Wang G, Wang MY, Hu YW, Yuan ZH. Genotype distribution of norovirus around the emergence of Sydney 2012 and the antigenic drift of contemporary GII.4 epidemic strains. Journal of Clinical Virology, 2015, 72:95-101.