郭文正 - 同济大学

个人简介

上海交通大学医学院医学博士，美国Markey Cancer Center（UK）博士后，上海市青年科技“启明星”，浦东新区“优青”，同济大学优秀青年人才，现任同济大学副教授，同济大学附属东方医院检验科（南院）副主任技师。近三年承担国家自然科学基金2项，2022年入选上海市青年科技启明星，获浦东新区“优青”及同济大学优青人才项目资助。相关成果获浦东新区科技进步奖二等奖，上海市医学会青年学者，优秀青年科研成绩奖等。近五年发表SCI文章20余篇，相关工作发表在Cancer Res，Cell Death & Des等国际知名期刊。

研究领域

肿瘤发生发展的机制和转化研究

近期论文

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W Guo#, K Li#, B Sun#, D Xu, L Tong, H Yin. et.al Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2021 Feb 1;81(3):552-566. J Wu#, H Mu#, X Wan, W Guo*. Studying the effects of booster shots and antibody responses to the SARS-CoV-2 vaccination over time in health personnel. Front. Cell. Infect. Microbiol. 2023 13:1138631. W Dong#, M Hu#, W Guo#, J Wu, Y Wu. Multi-SUMOylation of NAC1 is essential for the growth of prostate cancer cells. Biochemical and Biophysical Research Communications 641 (2023) 148e154. W Guo#, Y Kuang#, J Wu#, D Wen#, A Zhou, Y Liao. et.al Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma. Front. Oncol. 2020 Jau 13. 10:53. W Guo #, M Hu #, J Wu #, A Zhou, Y Liao, H Song. et.al Gprc5a depletion enhances the risk of smoking-induced lung tumorigenesis and mortality. Biomed Pharmacother. 2019 Mar 19;114:108791. W Guo#, S Yu#, G Li, Q Xuan, S Yang, D Wen*, W Wu*. The analysis of characteristics of anti-SARS-CoV-2 antibodies in clinically COVID-19 patients. J Clin Res Ophthalmol. 2020 7(2): 081-086. Y Kuang #, W Guo #, J Ling #, D Xu, Y Liao, H Zhao.et.al Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway. Cell Death Dis. 2019 Apr 1;10(4):297. L Wang #, W Guo #, H Shen, J Guo, D Wen, Y Yu*, W Wu*. Plasma Microbial Cell-Free DNA Sequencing Technology for the Diagnosis of Sepsis in the ICU. Front Mol Biosci. 2021 May 28;8:659390. Hu M#, Guo W#, Liao Y, Xu D, Sun B, Song H. et.al Dysregulated ENPP1 increases the malignancy of human lung cancer by inducing epithelial-mesenchymal transition phenotypes and stem cell features. Am J Cancer Res. 2019 Jan 1;9(1):134-144. Li K#, Guo W#, Li Z, Wang Y, Sun B, Xu D. et.al ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage. Neoplasia. 2019 Jun;21(6):602-614 Wu J #, Guo W #, Wen D #, Hu G, Zhou A, Wu W *. Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin-specific peptidase 9, X-linked in oral squamous cell carcinoma. Cancer Med. 2018 Aug;7(8):4004-4011. Sun B#, Guo W#, Hu S, Yao F, Yu K, Xing J. et.al Gprc5a-knockout mouse lung epithelial cells predicts ceruloplasmin, lipocalin 2 and periostin as potential biomarkers at early stages of lung tumorigenesis. Oncotarget. 2017 Feb 21;8(8):13532-13544.