孙明明 - 同济大学

个人简介

主持科研项目主持国家自然科学基金面上项目1项，82170536，IPA-AhR通路对炎症性肠病肠黏膜树突状细胞及CD4+ T细胞功能调控机制的研究，2022/01-2025/12，55万，在研主持国家自然科学基金青年项目1项，81800486，RORγt调控肠黏膜组织中Th17细胞表达IL-10参与肠道炎症发生的机制研究，2019/01-2021/12，22万，结题

研究领域

炎症性肠病免疫学与微生物学

近期论文

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Sun M#，He C#, Chen L#, Yang W, Wu W, Chen F, Cao AT, Yao S, Dann SM, Dhar TGM, Salter-Cid L, Zhao Q, Liu Z*, Cong Y*. RORt represses Th17 cell IL-10 production to maintain their pathogenicity in inducing intestinal inflammation. J Immunol .2019; 202(1):79-92. Sun M#, Wu W#, Chen L#, Yang W, Huang X, Ma C, Chen F, Xiao Y, Zhao Y, Ma C, Yao S, Carpio VH, Dann SM, Zhao Q, Liu Z*, Cong Y*. Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Nat Commun. 2018; 9(1):3555 Wu W#, Sun M#, Chen F, Cao AT, Liu H, Zhao Y, Huang X, Xiao Y, Yao S, Zhao Q, Liu Z*, Cong Y*, Microbiota metabolite short chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol, 2017; 10(4): 946-956 Sun M, He C, Wu W, Zhou G, Liu F, Cong Y, Liu Z*, Hypoxia inducible factor-1α-induced IL-33 expression in intestinal epithelia contributes to mucosal homeostasis in inflammatory bowel disease. Clin Exp Immunol, 2017; 187(3): 428-440 Wu W#, Sun M#, Zhang HP#, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu Z, Liu Z*, Yang PC*, Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut, 2014; 63(12): 1883-1892 Sun M#, Wu W#, Liu Z*, Cong Y*, Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. J Gastroenterol, 2017; 52(1): 1-8 Sun M#, He C#, Cong Y*, Liu Z*, Regulatory immune cells in regulation of intestinal inflammatory response to microbiota. Mucosal Immunol, 2015; 8(5): 969-978 Lu Huiying#；Lin Jian; Xu Chunjin; Sun Mingming; Zuo Keqiang; Zhang Xiaoping; Li Mingsong; Huang Hailiang; Li Zhong; Wu Wei*; Feng Baisui; Liu* Zhanju*; Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis to alleviate severe ulcerative colitis, Clinical and Translational Medicine, 2021, 11(2): e334 Ge Yadong#; Sun Mingming; Wu Wei; Ma Caiyun; Zhang Cui; He Chong; Li Junxiang; Cong Yingzi; Zhang Dekui; Liu Zhanju*; MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases, Journal of Autoimmunity, 2019, 101: 109-120 He C#, Yu T#, Shi Y, Ma C, Yang W, Fang L, Sun M, Wu W, Xiao F, Guo F, Chen M, Yang H, Qian J, Cong Y*, Liu Z*, MicroRNA301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology, 2017; 152(6):1434-1448 He C#, Shi Y#, Wu R#, Sun M, Fang L, Wu W, Liu C, Tang M, Li Z, Wang P, Cong Y, Liu Z*, miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD. Gut, 2016; 65(12):1938-1950 Wu W#, Liu HP#, Chen F, Liu H, Cao AT, Yao S, Sun M, Evans-Marin HL, Zhao Y, Zhao Q, Duck LW, Elson CO, Liu Z*, Cong Y*, Commensal A4 bacteria inhibit intestinal Th2-cell responses through induction of dendritic cell TGF-β production. Eur J Immunol, 2016; 46(5): 1162-1167 Wu W#, He C#, Liu C#, Cao AT, Xue X, Evans-Marin HL, Sun M, Fang L, Yao S, Pinchuk IV, Powell DW, Liu Z*, Cong Y*, miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut, 2015; 64(11): 1755-1764