彭长庚 - 同济大学

个人简介

教育经历 2008.2- 2012.5 博士，德国国家环境与健康研究中心/慕尼黑工业大学，生物学 2003.9-2006.6 硕士，中科院上海生命科学研究院健康科学研究所，分子生物与生物化学专业 1999.9-2003.6 学士，山西大学，生物技术专业工作经历 2017.9-至今特聘研究员、硕士研究生导师、博士研究生导师，同济大学医学院、转化医学高等研究院 2012.6-2017.6 博士后研究员，瑞典卡罗林斯卡医学院医学生化与生物物理系。 2006.7-2007.9 研究助理，中科院上海生命科学研究院健康科学研究所

研究领域

利用分子生物学、RNA测序、生物信息学和电生理等技术在转基因小鼠模型和疾病小鼠模型上研究神经发育与神经病理及药物发现，主要包括： 1.疼痛基因网络调控和躯体感觉神经元分化的分子机制研究，并筛选、发现抑制疼痛的药物 2.疼痛传导环路及中枢痛敏的分子机制 3.研究中脑多巴胺神经元（mDA）的存活、诞生数目调控的分子机制，探寻帕金森病的早期诊断biomarker和诊断方法

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Sun L, Xia R, Jiang J, Wen T, Huang Z, Qian R, Zhang M, Zhou M, Peng C. MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord. Progress in Neurobiology，2021. 02. 23 Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K, Hu H. In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain. 2021 Jun 2:awab209. Zhou P, Qi Y, Fang X, Yang M, Zheng S, Liao C, Qin F, Liu L, Li H, Li Y, Ravindran E, Sun C, Wei X, Wang W, Fang L, Han D, Peng C, Chen W, Li N, Kaindl AM, Hu H. Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1. iScience. 2021 May 24;24(6):102645. Nouri P, Goetz S, Rauser B, Irmler M, Peng C, Trumbach D, Kempny C, Lechermeier C, Brybiok A, Dulugos A, Euchner E, Beckers J, Brodski C, Klumper C, Wurst W, Prakash N. Dose-dependent and subset-specific regulation of midbrain dopaminergic neuron differentiation by LEF1-mediated WNT1/b-catenin signaling. Frontiers in Cell and Developmental Biology. 2020 Oct 26;8:587778. Sun L#, Liu Y# and Peng C. Different Manners of Interplay between MicroRNAs and Gene Programs in Neuronal Specification. Journal of Cell Signaling. 2018, 3:4. Sun L, Xia R, Wen T, Jiang J, Huang Z , Zhang M, Peng C. An interaction gene network contributes to mechanical allodynia. (In submission) Peng C§，Furlan A, Zhang M, Su J, Lübke M， L?nnerberg P, Abdo H, Sontheimer J, Sundstr?m E, Ernfors P2§. Termination of cell-type specification gene programs by miR-183 cluster determines the population sizes of low threshold mechanosensitive neurons. Development. 2018 Sep 25;145(18):dev165613. (§共同通讯作者). Zhang M, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, L?w P, Borgius L, O, Watanabe M, M, Mitsios N, Mulder J, Harkany T*，H?kfelt T*. Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity. Journal Of Clinical Investigation. 2018 July 30. https://doi.org/10.1172/JCI120913. Yang S, Toledo E, Rosmaninho P, Peng C, Uhlén P, Castro D, Arenas E. A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Communications Biology volume 1, Article number: 75 (2018). https://doi.org/10.1038/s42003-018-0080-0. Peng C, Li L, Zhang M, Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, H?ring M, Lallemend F, Harkany T, Diatchenko L, H?kfelt T, Hjerling-Leffler J and Ernfors P. MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science. 2017 Jun 16;356(6343):1168-1171. （Science同期杂志上发表了Perspective review， F1000优秀论文） Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. J Neurosci. 2012 Sep 19;32(38):13292-308. Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, and Le W. Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci. 2011 Sep;31, 12802-12815. Peng C, Fan S, Li X, Fan X, Ming M, Sun Z, Le W. Overexpression of pitx3 upregulates expression of BDNF and GDNF in SH-SY5Y cells and primary ventral mesencephalic cultures. FEBS Lett. 2007 Apr 3;581(7):1357-61. Epub 2007 Mar 2. Li X, Peng C, Li L, Ming M, Yang D, Le W. Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation. J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):943-50. Yang, D., Peng, C., Li, X., Fan, X., Li, L., Ming, M., Chen, S., and Le, W. Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures. J Neurosci Res.2008 Nov; 86(15), 3393-3400. Li X, Yang D, Li L, Peng C, Chen S, Le W. Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures. Neurochem Int. 2007 Jun;50(7-8):959-65. Epub 2007 May 3.