梁兴群 - 同济大学

个人简介

教授，博士生导师，美籍华人，毕业于北京协和医科大学， MD&PhD。主要从事心血管和神经系统的发育，功能及病变。其中以第一作者、共同作者在Nature，Nature Neuroscience， Circulation，Circulation Research和JCI等杂志发表论文。2011年回国工作后，作为通讯、第一和共同作者发表论文17余篇，包括领域顶级杂志Circulation Research，JCI，BMC等。获国家自然科学基金面上项目，国家创新研究群体科学奖，973项目，上海市创新项目和上海市浦江人才计划的资助。教育、工作经历中国协和医学科学院，1991.09-1995.07 医学硕、博士。提前毕业芬兰赫尔辛基大学生物技术研究所，1996.07-2001. 05博士后研究员和研究科学家哈佛大学哈佛医学研究所， 2001.05-2002.10 博士后研究员加州大学圣地亚哥分校医学系 2002.10-2004.07 博士后研究员研究员 2004.07-2010.07 研究助理教授（科学家） 2010.07-2011.01 研究副教授，通过美国医生资格考试 2011.01 至今同济大学医学院病理生理学系，心律失常教育部重点实验室、同济大学附属东方医院医学转化平台，教授，博硕士生导师，PI

研究领域

主要研究方向为心血管及传导系统发育及功能、心脏干细胞和外周神经系统发育及功能的研究。 1.心脏、起搏传导系统以及血管的发育与功能的调控机制。 2.心脏再生的转化医学研究 1）心脏细胞的谱系起源以及在心脏不同结构形成中的作用及调控机制 2）心脏起搏器的形成和调控机制 3）外周神经系统的形成调控机制专注基因功能和分子调控机制及其在先天性心脏病，心律失常，心脏再生的转化医学研究。 3.血管形成调控机制与血管疾病阐明整合素信号通路介导的细胞和信号相互作用： 1）血管内皮细胞中的作用机制 2）在血管平滑肌中的作用机制 3）如何介导各血管细胞的相互作用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Gao R, Liang X*, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G. Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019 Jun;29(6):486-501. doi: 10.1038/s41422-019-0168-1. Epub 2019 Apr 25. Qitong Zhang, Qingquan Zhang, Xue Jiang, Youqiong Ye, Huimin Liao, Fugui Zhu, Jie Yan, Lina Luo1, Li Tian, Cizhong Jiang, Yihan Chen, Xingqun Liang* Yunfu Sun*. Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. Theranostics . 2019; 9(4): 986-1000. Gong X, Guo X,Huang R,Liao H, Zhang Q, Yan J, Luo L, Zhang Q, Qiu A, Sun Y, Liang X. Expression of ILK in renal stroma is essential for multiple aspects of renal development. Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F374-F385. Zhang Q, Huang R, Ye Y, Gong X, Lu J, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Yan J, Luo L, Banerjee I, Chen Y, Glass CK, Jiang C*, Liang X*, Sun Y*. Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell death and disease. 2018 Feb 14;9(2):247. Xingqun Liang, Sylvia M. Evans, Yunfu Sun. Development of the cardiac pacemaker. Cellular Biology Life Science. (2017) 74:1247–1259. 通讯作者 Ye M, Zhang Q, Xu X, Zhang Q, Ge Y, Geng P, Yan J, Luo L, Sun Y, Liang X. Loss of JAM-C leads to impaired esophageal innervations and megaesophagus in mice. Diseases of the Esophagus. (2016) 29, 864–871. 通讯作者 Tommi Anttonen, … Xingqun Liang, Ulla Pirvola. c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea1,2,3. eNeuro. 2016 Mar-Apr, Published online. Liang X*, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Isl1 Is an Essential Regulator of Pacemaker Development and Function. J Clin Invest. 2015 Aug 3; 125(8):3256-68. 通讯作者 Liang X, Evans SM, Sun Y. Insights into Cardiac Conduction System Formation Provided by HCN4 Expression. Trends in Cardiovascular Medicine. 2015，25(1)：1-9 Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. Nebulette knockout mice have normal cardiac function, but showZ-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15;107(2):216-25. doi: 10.1093/cvr/cvv156. Epub 2015 May 17 第一作者 Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X*. Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013 Oct 16; 11:107. 通信作者 Zhuang S, Zhang Q, Zhuang T, Evans SM, Liang X*, Sun Y. Expression of Isl1 during mouse development. Gene Expr Patterns. 2013 Jul 29;13(8):407-412. 通信作者 Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y*, Evans SM*. HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors. Circ Res. 2013 Aug 2;113(4):399-407. Epub 2013 Jun 6. Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y. Isl1 Is required for multiple aspects of motor neuron development. Mol. Cell. Neurosci. 2011 April 26;8-15. Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E. Benson W, Ivy D, Perryman MB, Garrett-Sinha LA, Grossfeld P. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects in mice. Human Molecular Genetics. 2010;19:648. Liang X, Sun YF and Chen J. Particularly Interesting Cysteine- and Histidine-Rich Protein in Cardiac Development and Remodeling. J Investig Med. 2009 Dec 57(8):842-8. Liang XQ, Sun YF, Yi MQ, Paul H Evans SE and Ju Chen. Inactivation of PINCH1 and PINCH2 Disrupts Cardiomyocytes Focal Adhesion, Resulting in Cardiomyopthy and Heart Failure. Circulation. 2009 Aug 18; 120(7):568-76. Epub 2009 Aug 3. Sun YF, Dykes IM, Liang XQ, Eng SR, Evans SM, Turner EE. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov; 11(11):1283-93. Epub 2008 Oct 12. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature, 2008 Jul 3; 454(7200):104-8. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomer mediates hypertrophic biomechanical stress response in mice. J Clin Invest. 2008;118:3870 Sun Y, Liang X*, Najafi N, Cass M, Lin L, Cai CL, Chen J, and Evans SM. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007; 304(1):286-96. (*equal contribution) Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007; 100(4): 527-535. Sun YF, Liang XQ*, and Evans SM. (2007). Islet1 Progenitors in Developing and Postnatal Heart. Cardiovascular Development (ADB series). (*equal contribution) Sheikh F, Chen TH, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton NE, Yajima T, Lu YC, Fusch E, Knowlton KU, Peterson KL, Perriard JC and Chen J. alpha-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction Resulting in Cardiomyopathy and Susceptibility to Wall Rupture. Circulation. 2006; 114: 1046-55. Liang X, Zhou Q, Li X, Sun Y, Lu M, Dalton N, Ross J Jr, and Chen J. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005; 25(8):3056-62 Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, and Evans SM. Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart. Dev Cell. 2003; 5:877 Liang X, Hava Avraham, Shuxian Jiang, Tae-Aug Kim, and Shalom Avraham . Genetic alterations of NRP/B gene associated with human brain tumors. Cancer Res 2004; 23: 5890-5900. 专著 Yunfu Sun, Liang X, and Sylvia Evans. (2007). Islet1 Progenitors in Developing and Postnatal Heart Cardiovascular Development. Advance in Developmental Biology. 2008 (18): 154-65. Shalom Avraham, Hava Avraham, Shuxian Jiang, Xia Bu, Liang X, Seyha Seng and Tae-Aug Kim (2002). The superfamily of proteins containing Kelch and/or BTB domains: From cytoskeleton dynamics to transcriptional regulation. Recent Res. Devel. Bio. Chem. (Review, book). 1:231-254.