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个人简介

蒋晓燕,同济大学医学院心律失常教育部重点实验室教授,博士生导师。为如皋衰老纵向队列的核心建设者(Rugao Longevity and Ageing Study, RuLAS)Co-PI,建立队列数据库,建立多学科(各器官、系统、社会心理)表型、基因组、代谢组、宏基因组等多组学数据库。研究方向:心血管与代谢性疾病分子和遗传流行病学。长期从事心血管代谢性疾病及衰弱的分子和遗传流行病学研究,并有多年的多基因病与药物遗传学咨询、心血管药理学及病理生理学研究教学经历。主持国家自然科学基金面上项目、国家自然科学基金青年基金、国家教育部博士点新教师基金、上海市自然科学基金、中央高校基本科研业务费专项基金等项目。为国家重点研发计划“主动健康和老龄化科技应对”专项“老年衰弱快速筛查评估量表的研发与建立”任务责任人。发表SCI论文50多篇,其中以通讯或第一作者(含并列)名义发表SCI论文26篇。获济南市科技进步二等奖(2015,排名第二)。是国家自然科学基金及教育部博士学位论文评审专家以及J Nutr Health Aging、Frontiers in Public Health、Molecular Biology Reports、Psychiatry Research等国际SCI期刊的审稿人。

研究领域

长期从事心血管代谢性疾病及衰弱的分子和遗传流行病学研究,并有多年的多基因病与药物遗传学咨询、心血管药理学及病理生理学研究教学经历

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

H Zhang#, M Sun#, Z Hu, Y Cao, M Hao, Y Li, L Jin, X Sun, X Wang, X Jiang*. Association of Arterial Stiffness with Functional Disability and Mobility Limitation: The Rugao Longitudinal Ageing Study. J Nutr Health Aging. 2022; Online ahead of print. (corresponding author) Yuan JL#, Zhao RX#, Ma YJ, Li XD, Zhou XM, Wang XF, Jiang XY*, Li SJ*. Prevalence/potential risk factors for motoric cognitive risk and its relationship to falls in Chinese elderly people: A cross-sectional study. Eur J Neurol. 2021 Aug;28(8):2680-2687. doi: 10.1111/ene.14884. (co-corresponding author) Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*.Cognitive frailty and falls in Chinese older people:a population-based longitudinal study. Eur J Neurol. 2021 Feb; 28(2):381-388. doi: 10.1111/ene.14572.(co-corresponding author) Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*. Cognitive frailty predicting death and disability in Chinese elderly. Neurol Res. 2021 Oct;43(10):815-822. doi: 10.1080/01616412.2021.1939235. (co-corresponding author) Guo JH#, Shi JM#, Shi GP, Wang Y, Chu XF, Wang ZD, Yao S, Sun XH, Wang XF, Zhu YS*, Jiang XY*. Association Study of Mitochondrial DNA Haplogroup D and C5178A Polymorphisms with Chronic Kidney Disease. Genet Test Mol Biomarkers. 2021 Aug;25(8):546-550. doi: 10.1089/gtmb.2020.0306. (co-corresponding author) Chen Z#, Jiang X#, Shi G, Wang Y, Chu X, Wang Z, Guo J, Zhu Y, Chen J, Wang X, Bao Z*. Social frailty and longitudinal risk of depressive symptoms in a Chinese population: the Rugao Longevity and Aging Study. Psychogeriatrics. 2021 Jul;21(4):483-490. doi: 10.1111/psyg.12696. Epub 2021 May 6. (co-first author) Sun XH#, Ma T#, Yao S, Chen ZK, Xu WD, Jiang XY*, Wang XF*. Associations of sleep quality and sleep duration with frailty and pre-frailty in an elderly population Rugao longevity and ageing study. BMC Geriatr. 2020 Jan 6;20(1):9. doi: 10.1186/s12877-019-1407-5. (co-corresponding author) Ma T#, Sun XH#, Yao S, Chen ZK, Zhang JF, Xu WD, Jiang XY*, Wang XF*. Genetic Variants of Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity and Ageing Study.J Nutr Health Aging. 2020;24(2):198-204. doi: 10.1007/s12603-019-1304-9. (co-corresponding author) Li YX#, Jiang XY#, Stone C, Ma YJ, Liu Q, Hu ZH, Li XD, Wang XF, Li SJ. A new physical-cognitive scale for assessment of frailty in Chinese Han elderly. Neurol Res. 2019 Aug;41(8):728-733. doi: 10.1080/01616412.2019.1609164. Epub 2019 Apr 28. (co-first author) Shi GP#, Ma T#, Zhu YS, Wang ZD, Chu XF, Wang Y, Chen ZK, Xu WD, Wang XF, Guo JH, Jiang XY*. Frailty phenotype, frailty index and risk of mortality in Chinese elderly population- Rugao longevity and ageing study. Arch Gerontol Geriatr. 2019 Jan - Feb;80:115-119. doi: 10.1016/j.archger.2018.11.001. Epub 2018 Nov 6.(co-corresponding author) Ma T #, Cai J#, Zhu Y, Chu X, Wang Y, Shi G, Wang Z, Yao S, Wang X*, Jiang X*. Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the rugao longevity and Ageing study. Clin Interv Aging. 2018;13:797-804. eCollection 2018. (co-corresponding author) Zheng HX#, Li L#, Jiang XY#, Yan S, Qin Z, Wang X, Jin L. MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Hum Genet (2017) 136:1353–1362. (co-first author) Wang Y#, Ma T#, Zhu YS, Chu XF, Yao S, Wang HF, Cai J, Wang XF*, Jiang XY*. The KSR2-rs7973260 Polymorphism is Associated with Metabolic Phenotypes, but Not Psychological Phenotypes, in Chinese Elders. Genet Test Mol Biomarkers. 2017 Jul;21(7):416-421. (co-corresponding author) Zhi T#, Wang Q#, Liu Z#, Zhu Y, Wang Y, Shi R, Wang Z, Chu X, Wang X, Jiang X*. Body mass index, waist circumference and waist-hip ratio are associated with depressive symptoms in older Chinese women: results from the Rugao Longevity and Ageing Study (RuLAS). Aging Ment Health. 2017 May;21(5):518-523. doi: 10.1080/13607863.2015.1124837. Epub 2015 Dec 21. (corresponding author) Hao M#, Zhang H#, Hu Z, Jiang X, Song Q, Wang X, Wang J, Liu Z*, Wang X*, Li Y*, Jin L*. Phenotype correlations reveal the relationships of physiological systems underlying human ageing. Aging Cell. 2021 Dec;20(12):e13519. Zhang H#, Zhu Y#, Hao M, Wang J, Wang Z, Chu X, Bao Z, Jiang X, Shi G*, Wang X*. The modified Healthy Aging Index is Associated with Mortality and Disability: The Rugao Longevity and Ageing Study. Gerontology. 2021;67(5):572-580. Zhang H#, Zhu Y#, Gong W, Sun X, Jiang X, Wang J, Jin L, Xu X, Luo D*, Wang X*. Plasma Homocysteine and Macular Thickness in Older Adults-the Rugao Longevity and Aging Study. Eye (Lond). 2021. Online ahead of print. Zhang H#, Li Y#, Hao M, Jiang X, Wang J, Jin L, Bao Z*, Wang X*. Kidney function decline is associated with an accelerated increase in plasma homocysteine in older adults: a longitudinal study. Br J Nutr. 2021, 24:1-7. Chu X#, Zhang N#, Shi G, Wang Y, Wang Z, Guo J, Jiang X, Jin L, Wang X*, Zhu Y*. Frailty and Incident Depressive Symptoms in a Chinese Sample: The Rugao Longevity and Ageing Study. Psychogeriatrics. 2020;20(5):691-698. Wang Z#, Yao S#, Shi G, Wang Y, Shi J, Guo J, Zhu Y, Jiang X, Chu X*, Wang X*.Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32(2):305-311. Yao S, Zhu Y , Shi G, Guo J, Wang Z, Chu X, Jiang X, Jin L*, Wang X*. Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. J Nutr Health Aging. 2020;24(3):358-363. Zhang N#, Shi GP#, Wang Y, Chu XF, Wang ZD, Shi JM, Guo JH, Wang YC, Yao S, Jiang XY, Zhu YS*, Wang XF*. Depressive symptoms are associated with incident frailty in a Chinese population- the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32(11):2297-2302. Yao S#, Guo J#, Shi G, Zhu Y, Wang Y, Chu X, Jiang X, Jin L, Wang Z*, Wang X*. Association Of BNP with frailty in elderly population: Rugao Longevity and Ageing Study. J Nutr Health Aging. 2019;23(1):73-78. Ma T, Lu D, Zhu Y, Chu X, Wang Y, Shi G, Wang Z, Yu L, Jiang X, Wang X*.ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. Age Ageing. 2018;47(3):416-422. Liu Q#, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Comparing associations of different metabolic syndrome definitions with ischemic stroke in Chinese elderly population. Eur J Intern Med. 2018,47:75-81. Liu Q, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Reduced estimated glomerular filtration rate is associated with depressive symptoms in elder Chinese: A population-based cross-sectional study. Neurosci Lett. 2018;666:127-132. Ma T#, Shi G#, Zhu Y, Wang Y, Chu X, Jiang X, Liu Z, Cai J, Wang H, Jin L, Wang Z*, Wang X*. Sleep disturbances and risk of falls in an old Chinese population-Rugao Longevity and Ageing Study. Arch Gerontol Geriatr. 2017,12;73:8-14. Liu Q#, Li Y, Hu Z, Jiang X, Li S*, Wang X*. Reduced estimated glomerular filtration rate is associated with depressive symptoms in elder Chinese: a population-based cross-sectional study. Neurosci Lett. 2017;666:127-132.

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