黄莺 - 同济大学

个人简介

本科，博士毕业于复旦大学医学院，在美国NIMH,NIH接受博士后训练。研究受到国家自然科学基金（面上三项），上海市自然科学基金等经费支持。近年来发表论文二十余篇，以通讯作者在British Journal of Pharmacology, Front Cell Neurosci, Cerebral Cortex, J Pain等国际杂志上发表前沿性学术论文。指导及协助指导博士硕士研究生多名。并担任IBRO Neuroscience Report, Frontiers in Endocrinology, Frontiers in Neuroscience，Frontiers in Behavioral Neuroscience等国际学术期刊编辑及审稿。

研究领域

认知记忆的神经环路、神经可塑性机制及认知障碍性疾病：神经可塑性是脑内学习记忆在神经元之间突触层面的重要机制，而神经网络的同步性活动参与不同神经元集群的信息编码和整合，是更为宏观层面的脑认知功能的神经基础。神经可塑性的损害和网络同步性异常将导致认知记忆功能的障碍及疾病。我们的研究主要集中在神经可塑性（LTP，LTD等）调控的细胞机制、网络同步性活动（gamma, theta oscillation等）中不同种类神经元放电的pattern 和timing等在认知和认知障碍中的作用，包括运用转基因动物模型进行行为学研究，以及运用电生理，形态学，生化等方法进行机制探讨

近期论文

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Zhan TT#, Dong ZY#, Yi LS, Zhang Y, Sun HH, Zhang HQ, Wang JW, Chen Y, Huang Y*, Xu SC*. Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancement via 5-HT 1A receptors in anterior cingulate cortex in rats. Frontiers in Cellular Neuroscience. 2022 Aug 22; doi: 10.3389/fncel.2022.922750 Dong ZY#, Zhan TT#, Sun HH, Wang JW, Duan GB, Zhang Y, Chen Y, Huang Y*, Xu SC*. Astrocytic ERK/STAT1 signaling contributes to maintenance of stress-related visceral hypersensitivity in rats. J Pain. 2022 Jul 29; S1526-5900(22)00365-0. doi: 10.1016/j.jpain.2022.07.006. Yu Y, Li JJ, He XQ, Lai ZY, Hao R, Qi Y, Cao DQ, Fu M, Ma H, Xie QC, Sun M, Huang ZL, Jin LJ, Sun HH, Lu N, Wang R, Yung WH, Huang Y*. 5-HT3 A receptors maintain hippocampal LTP in a CB1 and GABAA receptor- dependent manner for spatial memory. Br J Pharmacol. 2022 Jun;179(12):2969-2985. doi: 10.1111/bph.15793. Epub 2022 Feb 14. Wang J, Hao R, Jiang T, Guo X, Zhou F, Cao L, Gao F, Wang G, Wang J, Ning K, Zhong C, Chen X*, Huang Y*, Xu J*, Gao S*. Rebuilding hippocampus neural circuit with hADSC-derived neuron cells for treating ischemic stroke. Cell Biosci. 2022 Apr 4;12(1):40. doi: 10.1186/s13578-022-00774-x. Wang S, Yao H, Xu Y, Hao R, Zhang W, Liu H, Huang Y, Guo W, Lu B. Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease. Theranostics. 2020 May 23;10(15):6854-6874. doi: 10.7150/thno.44165. eCollection 2020. Hao R, Qi Y, Hou DN, Ji YY, Zheng CY, Li CY, Yung WH, Lu B, Huang Y*. BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors. Front Cell Neurosci. 2017 11:306. Huang Y*, Yoon K, Ko H, Jiao S, Ito W, Wu JY, Yung WH, Lu B, Morozov A. 5-HT3a receptors modulate hippocampal gamma oscillations by regulating synchrony of parvalbumin-positive interneurons. Cerebral Cortex. 2016 26(2):576-585. Huang L, Yang XJ, Huang Y, Sun EY, Sun M*. Ketamine Protects Gamma Oscillations by Inhibiting Hippocampal LTD. PLoS One. 2016; 11(7):e0159192. Liu X, Zhang N, Ding Y, Cao D, Huang Y, Chen X, Wang R, Lu N*. Hydrogen Sulfide Regulates the [Ca2+]i Level in the Primary Medullary Neurons. Oxid Med Cell Longev. 2016: 2735347. Yu Y, Cao DQ, Xu HY, Sun M, Huang ZL, Yung WH, Lu N, Huang Y*. 5-HT3A receptors are required in long-term depression and AMPA receptor internalization. Neuroscience. 2014. 278:105-112. Huang Y, Wang JJ, Yung WH*. Coupling between GABA-A receptor and chloride transporter underlies ionic plasticity in cerebellar Purkinje neurons. Cerebellum. 2013,12(3):328-330. Huang Y*, Ko H, Cheung ZH, Yung KK, Yao T, Wang JJ, Morozov A, Ke Y, Ip NY, Yung WH*. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental Neurology. 2012, 233(2):791-798. Huang Y, Morozov A*. Hippocampal deletion of BDNF gene attenuates Gamma oscillations in area CA1 by up-regulating 5-HT3 receptor. PLoS ONE. 2011, 6(1): e16480. Ma YY, Li KY, Wang JJ, Huang YL, Huang Y, Sun FY. Vascular endothelial growth factor acutely reduces calcium influx via inhibition of the Ca2+ channels in rat hippocampal neurons. J Neurosci Res. 2009 87(2):393-402. Huang Y, Huang YL, Lai B, Zheng P, Zhu YC, Yao T*. Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high voltage-activated calcium current. Neuroscience 2007; 147:334-341. He Y, Huang Y, Zhou L, Lu LM, Zhu YC, Yao T*. All-trans retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts. Acta Pharmacologica Sinica. 2006;27:423-429. Zhang S, Huang Y, Yao T*. Estrogen stimulates the release of secreted amyloid precursor protein from primary rat cortical neurons via protein kinase C pathway. Acta Pharmacologica Sinica. 2005; 26: 171-176. Huang Y, Huang YL, Zhang S, Zhu YC, Yao T*. Estradiol acutely attenuates glutamate-induced calcium overload in primarily cultured rat hippocampal neurons through a membrane receptor-dependent mechanism. Brain Research. 2004; 1026: 254-260.