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个人简介

曾任上海交通大学海科院助理研究员和复旦大学上海医学院副教授;先后在美国亚历桑那大学生物化学系和美国西奈山医学院分子生物物理学系做博士后训练和访问学者,美国西奈山医学院儿科系研究员;回国后组建了同济大学医学院医学遗传学教研室并任创建主任; 目前担任同济大学医学院教授委员会主任;心律失常教育部重点实验室常务副主任;同济大学医学院转化医学管理办公室主任;国家留学基金委评审专家;美国人类遗传学会会员;国际干细胞研究协会会员;上海浦江人才计划获得者。

研究领域

干细胞分化的表观遗传机制研究;心脏重构和心脏疾病大鼠模型的研究;遗传疾病分子机制研究

近期论文

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Wang D, Liu C, Wang Y, Wang W, Wang K, Wu X, Li Z, Zhao C, Li L, Peng L.,Impact of miR-26b on cardiomyocyte differentiation in P19 cells through regulating canonical/non-canonical Wnt signaling,Cell Prolif.,2017 Wang D, Liu C, Li Z, Wang Y, Wang W, Wu X, Wang K, Miao W, Li L, Peng L.,Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.,J Cell Biochem,2017 Liu JJ, Zhao CM, Li ZG, Wang YM, Miao W, Wu XJ, Wang WJ, Liu C, Wang D, Wang K, Li L, Peng LY.,miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST.,Int J Mol Sci.,2016 Miao W, Wu X, Wang K, Wang W, Wang Y, Li Z, Liu J, Li L, Peng L.,Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2.,Int J Mol Sci,2016 Hu T, Wang D, Yu Q, Li L, Mo X, Pan Z, Zouboulis CC, Peng L, Xia L, Ju Q.,Aryl hydrocarbon receptor negatively regulates lipid synthesis and involves in cell differentiation of SZ95 sebocytes in vitro.,Chem Biol Interact,2016 Li J, Li C, Liang D, Lv F, Yuan T, The E, Ma X, Wu Y, Zhen L, Xie D, Wang S, Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L, Lin L, Peng L, Cui J, Zhu W, Chen YH.,LRP6 acts as a scaffold protein in cardiac gap junction assembly.,Nat Commun,2016 Xu L, Pan L, Li J, Huang B, Feng J, Li C, Wang S, The E, Liu Y, Yuan T, Zhen L, Liang D, Liu Y, Li L, Cui Y, Jiang X, Peng L, Chen YH.,Nucleoporin 35 regulates cardiomyocyte pH homeostasis by controlling Na+-H+ exchanger-1 expression,J Mol Cell Biol.,2015 Zhao CM, Peng LY, Li L, Liu XY, Wang J, Zhang XL, Yuan F, Li RG, Qiu XB, Yang YQ.,PITX2 Loss-of-Function Mutation Contributes to Congenital Endocardial Cushion Defect and Axenfeld-Rieger Syndrome.,PLoS One,2015 Li J, Li C, Zhang D, Shi D, Qi M, Feng J, Yuan T, Xu X, Liang D, Xu L, Zhang H, Liu Y, Chen J, Ye J, Jiang W, Cui Y, Zhang Y, Peng L, Zhou Z, Chen YH.,SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain,Nat Commun,2014 Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH.,Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.,J Cell Mol Med.,2014 Liang D, Zhen L, Yuan T, Huang J, Deng F, Wuyahan, Zhang H, Pan L, Liu Y, The E, Yu Z, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH.,miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6.,PLoS One,2014 Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen YH.,Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy,Cell Res,2014 Li L, Liu C, Wang F, Miao W, Zhang J, Kang Z, Chen Y, Peng L.,Unraveling the hidden heterogeneities of breast cancer based on functional miRNA cluster.,PLoS One,2014 Zhang J, Song R, Li Y, Feng J, Peng L, Li J.,Integration of microarray profiles associated with cardiomyopathy and the potential role of Ube3a in apoptosis.,Mol Med Rep,2014 Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X.,Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis,BMC Biol,2013 Li J, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH.,Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis.,J Cell Mol Med,2013 Li RG, Li L, Qiu XB, Yuan F, Xu L, Li X, Xu YJ, Jiang WF, Jiang JQ, Liu X, Fang WY, Zhang M, Peng LY, Qu XK, Yang YQ.,GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.,Biochem Biophys Res Commun.,2013 Zhang J, Li L, Peng L, Sun Y, Li J.,An efficient weighted graph strategy to identify differentiation associated genes in embryonic stem cells.,PLoS One,2013 Li L, Chen H, Liu C, Wang F, Zhang F, Bai L, Chen Y, Peng L.,A robust hybrid approach based on estimation of distribution algorithm and support vector machine for hunting candidate disease genes.,ScientificWorldJournal.,2013 Li J, Zhang DS, Ye JC, Li CM, Qi M, Liang DD, Xu XR, Xu L, Liu Y, Zhang H, Zhang YY, Deng FF, Feng J, Shi D, Chen JJ, Li L, Chen G, Sun YF, Peng LY, Chen YH.,Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis.,Int J Cardiol.,2013 Xiao J, Liang D, Liu Y, Zhang H, Liu Y, Zhao H, Li J, Peng L, Zhou Z, Chen YH.,Taxol, a microtubule stabilizer, improves cardiac functional recovery during postischemic reperfusion in rat in vitro.,Cardiovasc Ther.,2012 Xiao J, Cao H, Liang D, Liu Y, Zhang H, Zhao H, Liu Y, Li J, Yan B, Peng L, Zhou Z, Chen YH.,Taxol, a microtubule stabilizer, prevents ischemic ventricular arrhythmias in rats.,J Cell Mol Med,2011 Xiao H, Chai Z, Wang HF, Wang XW, Cao DD, Liu W, Lu YP, Yang YQ, Zhao G.,Bifunctional N-acyl-aminophosphine-catalyzed asymmetric [4+2] cycloadditions of allenoates and imines.,Chemistry,2011 Xiao J, Jing ZC, Ellinor PT, Liang D, Zhang H, Liu Y, Chen X, Pan L, Lyon R, Liu Y, Peng LY, Liang X, Sun Y, Popescu LM, Condorelli G, Chen YH.,MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism.,J Transl Med.,2011 Yang Y, Yang Y, Liang B, Liu J, Li J, Grunnet M, Olesen SP, Rasmussen HB, Ellinor PT, Gao L, Lin X, Li L, Wang L, Xiao J, Liu Y, Liu Y, Zhang S, Liang D, Peng L, Jespersen T, Chen YH.,Identification of a Kir3.4 mutation in congenital long QT syndrome.,Am J Hum Genet.,2010 Xiao J, Zhang H, Liang D, Liu Y, Liu Y, Zhao H, Li J, Peng L, Chen YH,Taxol, a microtubule stabilizer, prevents atrial fibrillation in in vitro atrial fibrillation models using rabbit hearts,Med Sci Monit,2010 Li J, Yan B, Huo Z, Liu Y, Xu J, Sun Y, Liu Y, Liang D, Peng L, Zhang Y, Zhou ZN, Shi J, Cui J, Chen YH.,beta2- but not beta1-adrenoceptor activation modulates intracellular oxygen availability.,J Physiol. ,2010 Xiao J, Liang D, Zhao H, Liu Y, Zhang H, Lu X, Liu Y, Li J, Peng L, Chen YH.,2-Aminoethoxydiphenyl borate, a inositol 1,4,5-triphosphate receptor inhibitor, prevents atrial fibrillation.,Exp Biol Med (Maywood),2010 Xiao J, Zhao H, Liang D, Liu Y, Zhang H, Liu Y, Li J, Peng L, Zhou Z, Chen YH.,Taxol, a microtubule stabilizer, improves cardiac contractile function during ischemia in vitro.,Pharmacology,2010 Li J, Xiao J, Liang D, Zhang H, Zhang G, Liu Y, Zhang Y, Liu Y, Yu Z, Yan B, Jiang B, Li F, Peng L, Zhou ZN, Chen YH.,Inhibition of mitochondrial translocator protein prevents atrial fibrillation.,Eur J Pharmacol.,2010 Peng L, Li ZR, Green RS, Holzman IR, Lin J.,Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers.,J Nutr,2009 Zhao C, Qi J, Liu X, Chen H, Li J, Liu Y, Liang L, Zhang Y, Xiao J, Li L, Peng L, Xu J, Ma J, Yang Y, Wu X, Chen YH.,Refractoriness of the sheep superior vena cava myocardial sleeve.,Exp Biol Med (Maywood),2008 Liang L, Pan Q, Liu Y, Chen H, Li J, Brugada R, Brugada P, Hong K, Perez GJ, Zhao C, Qi J, Zhang Y, Peng L, Li L, Chen YH.,High sensitivity of the sheep pulmonary vein antrum to acetylcholine stimulation.,J Appl Physiol,2008 Pan Q, He Y, Zhang Z, Liu Y, Zhou Q, Li J, Li P, Liang L, Zhao C, Qi J, Peng L, Chen YH.,Spatial heterogeneity of muscarinic type 2 receptors in the atrium.,Int J Cardiol.,2008 Yang Y, Liu Y, Dong X, Kuang Y, Lin J, Su X, Peng L, Jin Q, He Y, Liu B, Pan Z, Li L, Zhu Q, Lin X, Zhou Q, Pan Q, Eurlings PM, Fei J, Wang Z, Chen YH.,Human KCNQ1 S140G mutation is associated with atrioventricular blocks.,Heart Rhythm.,2007 Peng L, He Z, Chen W, Holzman IR, Lin J.,Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier.,Pediatr Res,2007 Lin J, Peng L, Itzkowitz S, Holzman IR, Babyatsky MW.,Short-chain fatty acid induces intestinal mucosal injury in newborn rats and down-regulates intestinal trefoil factor gene expression in vivo and in vitro.,J Pediatr Gastroenterol Nutr,2005 Nafday SM, Chen W, Peng L, Babyatsky MW, Holzman IR, Lin J. ,Short-chain fatty acids induce colonic mucosal injury in rats with various postnatal ages.,Pediatr Res,2005 Peng L, Mirshahi T, Zhang H, Hirsch JP, Logothetis DE.,Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.,J Biol Chem.,2003 Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE.,The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.,Mol Cell,2002

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