戴亚蕾 - 同济大学

个人简介

获东南大学医学院医学学士，英国南安普顿大学博士及博士后。曾在英国和美国多所大学或研究所从事研究工作。2003年起任同济大学教授，博导，承担本科和研究生免疫学相关课程教学工作，主持和参与教改多项。目前科研主要从事固有免疫应答与炎症相关疾病研究，如动脉粥样硬化早期发病机制、结核致病机理等。承担国家自然科学基金项目和参与973项目及国家重点科研项目10余项，发表学术论文50余篇，其中SCI收录30余篇。主要任职科研业绩同济大学医学院免疫学教研室主任基础医学免疫学专业硕士学位点负责人国家自然科学基金、上海市科委项目等评议专家中国药理学会来华留学生（医学）教育工作委员会副主任委

研究领域

炎症对固有免疫应答的调控分子机制 1）结核杆菌与宿主固有免疫应答：主要探讨结核杆菌早期分泌蛋白ESAT-6对巨噬细胞的作用机制 2）黏附分子在固有免疫应答中的作用及其机制：主要探讨NP65分子在巨噬细胞抗感染功能的影响及其分子机制

近期论文

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Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis induces transition of macrophages into epithelioid macrophages by downregulating iNOS / NO-mediated H3K27 trimethylation in macrophages. Molecular Immunology 117:189–200, 2020. doi.org/10.1016/j.molimm.2019.11.013 Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages. Molecular and Cellular Biochemistry 457:179–189, 2019. DOI 10.1007/s11010-019-03522-x Vascular endothelial cells senescence is associated with NLRP3 inflammasome activation via ROS/TXNIP pathway. The International Journal of Biochemistry & Cell Biology. 84: 22-34, 2017. doi: 10.1016/j.biocel.2017.01.001. Downregulation of B-myb promotes senescence via ROS mediated p53/p21 pathway in vascular endothelial cells. Cell Proliferation A(50)2, 2017. doi: 10.1111/ cpr.12319. Epub 2016 Nov 23 SOCS3 and its role in associated diseases. Human Immunology 76(10):775-780, 2015. doi: 10.1016/ j.humimm. 2015.09.037. OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation. Inflammation Research 63(1):33-43, 2014. doi: 10.1007/s00011-013-0667-3. The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by mycobacterium tuberculosis ESAT-6. Inflammation 37(3):880-892, 2014. doi: 10.1007/s10753-013-9808-7. Modification of SR-PSOX functions by multi-point mutations of basic amino acid residues. Biochimie 95(1):224-230, 2013. doi: 10.1016/j.biochi.2012.09.016. The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 inregulating endothelial cell apoptosis. European Journal of Cell Biology 92(4-5):150-159, 2013. doi: 10.1016/j.ejcb.2013.01.001. The association of elevated 2′,5′-oligoadenylate -dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization. Lung Cancer 78:30-38, 2012. doi: 10.1016/j.lungcan.2012.07.010. An essential function for MKP5 inthe formation of oxidized low density lipid-induced foam cells. Cellular Signalling 24:1889-1898, 2012. doi: 10.1016/j.cellsig.2012.05.017 Function modification of SR-PSOX by point mutations of basic amino acids. Lipids in health and disease 10:59, 2011. doi:10.1186/ 1476-511X-10-59 Interleukin-10 down-regulates oxLDL induced expression of scavenger receptor A and Bak-1 inmacrophages derived from THP-1 cells. Archives of Biochemistry and Biophysics 512:30-37, 2011. doi: 10.1016/j.abb.2011.05.017. Effect of overexpression of human SR-A1 on ox-LDL uptake and apoptosis in 293T cells. International Immunopharmacology 11(11):1752-1757, 2011. doi: 10.1016/j.intimp.2011.07.001.