张霞 - 四川大学 - 生物治疗国家重点实验室

个人简介

2014年毕业于美国明尼苏达大学，获得药物化学博士学位。2015年受聘于四川大学华西生物治疗国家重点实验室，任副研究员。独立工作以来，以第一作者或通讯作者身份在Angewandte、Chemical Reviews、Organic Letters、European Journal of Medicinal Chemistry等权威期刊上发表文章10余篇。

研究领域

1）利用极性反转的策略合成手性胺类化合物的方法学研究 2）反应机理的理论研究与计算机辅助药物设计 3）胺类化合物和含糖化合物的药物化学以及化学生物学研究

近期论文

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Wang, Y. ⊥, Deng, L. ⊥, Zhang, X.*, Mou, Z., and Niu, D.*, A radical approach to make unnatural amino acids through converting C–S bonds in cysteine derivatives to C–C bonds. Angew. Chem. Int. Ed. 2021, 60, 2155–2159 Shang, W., Su, S.‐N., Shi, R., Mou, Z.‐D., Yu, G.‐Q., Zhang, X.*, and Niu, D.*, Generation of Glycosyl Radicals from Glycosyl Sulfoxides and Its Use in the Synthesis of C‐linked Glycoconjugates. Angew. Chem. Int. Ed. 2021, 60, 385–390 Wang, W. ⊥ ; Xiong Q. ⊥; Gong L., Wang Y., Liu J.*; Lan Y.*; Zhang X.*, Regio- and Enantioselective Palladium-Catalyzed Asymmetric Allylation of N‐Fluorenyl Trifluoromethyl Imine. Org. Lett. 2020, 22, 5479−5485. Yang, L. ⊥; Pu, X. ⊥; Niu, D.; Fu, Z.*; Zhang, X.*, Copper-Catalyzed Asymmetric Propargylation of Indolizines. Org Lett 2019, 21 (21), 8553-8557. Wang, Y.; Deng, L. F.; Zhang, X.*; Niu, D.*, Catalytic Asymmetric Synthesis of alpha-Tetrasubstituted alpha-Trifluoromethyl Homoallylic Amines by Ir-Catalyzed Umpolung Allylation of Imines. Org Lett 2019. Tang, S. T. ⊥; Zhang, X. ⊥; Sun, J. Y.; Niu, D.*; Chruma, J. J.*, 2-Azaallyl Anions, 2-Azaallyl Cations, 2-Azaallyl Radicals, and Azomethine Ylides. Chem Rev 2018, 118 (20), 10393-10457. Fu, Z. ⊥; Deng, N. ⊥; Su, S. N.; Li, H.; Li, R. Z.; Zhang, X.*; Liu, J.; Niu, D.*, Diastereo- and Enantioselective Propargylation of 5H-Thiazol-4-ones and 5H-Oxazol-4-ones as Enabled by Cu/Zn and Cu/Ti Catalysis. Angew Chem Int Ed Engl 2018, 57 (46), 15217-15221. Zhan, M. ⊥; Pu, X. ⊥; He, B.; Niu, D.; Zhang, X.*, Intramolecular Umpolung Allylation of Imines. Org Lett 2018, 20 (18), 5857-5860. Tian, L. ⊥; Gong, L. ⊥; Zhang, X.*, Copper-Catalyzed Enantioselective Synthesis of beta-Amino Alcohols Featuring Tetrasubstituted Tertiary Carbons. Adv Synth Catal 2018, 360 (10), 2055-2059. Cen, J.; Zheng, B. B.; Bai, R. B.; Zhang, L.; Zhang, F.*; Zhang, X.*, Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition. Oncotarget 2017, 8 (41), 69465-69476. Mou, Z. D. ⊥; Deng, N. ⊥; Zhang, F.; Zhang, J.; Cen, J.*; Zhang, X.*, "Half-sandwich" Schiff-base Ir(III) complexes as anticancer agents. Eur J Med Chem 2017, 138, 72-82. Zhang, L. ⊥; Ren, W. ⊥; Wang, X.; Zhang, J.; Liu, J.*; Zhao, L.*; Zhang, X.*, Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents. Eur J Med Chem 2017, 126, 1071-1082. Zhang, X.; Amin, E. A.*, Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors. J Mol Graph Model 2016, 63, 22-8.