近期论文
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Motifs in the amino-terminus of CENP-A are required for its accumulation within the nucleus and at the centromere.Jing R#, Xi J, Leng Y, Chen W, Wang G, Jia W, Kang J*, Zhu S*. Oncotarget. 2017 Jun 20;8(25):40654-40667(代表作).
Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects. Li G, Jiapaer Z, Weng R, Hui Y, Jia W, Xi J, Wang G, Zhu S, Zhang X, Feng D, Liu L, Zhang X, Kang J*. Stem Cell Reports. 2017 May 9;8(5):1270-1286.
Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice. Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J*. Cell Rep. 2017 Mar 21;18(12):2880-2892.
HDAC10 promotes lung cancer proliferation via AKT phosphorylation. Yang Y, Huang Y, Wang Z, Wang HT, Duan B, Ye D, Wang C, Jing R, Leng Y, Xi J, Chen W, Wang G, Jia W, Zhu S*, Kang J*. Oncotarget. 2016 Sep 13;7(37):59388-59401(代表作).
An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. Wei T, Chen W, Wang X, Zhang M, Chen J, Zhu S, Chen L, Yang D, Wang G, Jia W, Yu Y, Duan T, Wu M, Liu H, Gao S, Kang J*. Nucleic Acids Res. 2015 Jun 23;43(11):5409-22.
A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint. Zhu S#*, Jing R, Yang Y, Huang Y, Wang X, Leng Y, Xi J, Wang G, Jia W, Kang J*. J Biol Chem. 2015 May 1;290(18):11282-92(代表作).
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Shen J, Jia W, Yu Y, Chen J, Cao X, Du Y, Zhang X, Zhu S, Chen W, Xi J, Wei T, Wang G, Yuan D, Duan T, Jiang C, Kang J*. Stem Cells. 2015 Mar;33(3):661-73.
MiR-495 suppresses mesendoderm differentiation of mouse embryonic stem cells via the direct targeting of Dnmt3a.Yang D, Wang G, Zhu S, Liu Q, Wei T, Leng Y, Duan T, Kang J*. Stem Cell Res. 2014 Mar;12(2):550-61.
Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. Song C, Zhu S, Wu C, Kang J*. J Biol Chem. 2013 Sep 27;288(39):28021-33(代表作).
Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells. Chen W, Jia W, Wang K, Si X, Zhu S, Duan T, Kang J*. PLoS One. 2013 Jun 13;8(6):e66076.
Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, Wei T, Si X, Wang Q, Li Y, Leng Y, Deng A, Chen J, Wang G, Zhu S*, Kang J*. J Biol Chem. 2013 May 17;288(20):14510-21(代表作).
microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Guo X, Liu Q, Wang G, Zhu S, Gao L, Hong W, Chen Y, Wu M, Liu H, Jiang C, Kang J*. Cell Res. 2013 Jan;23(1):142-56.
MiR-138 promotes induced pluripotent stem cell generation through the regulation of the p53 signaling. Ye D, Wang G, Liu Y, Huang W, Wu M, Zhu S, Jia W, Deng AM, Liu H, Kang J*. Stem Cells. 2012 Aug;30(8):1645-54.
Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells. Yan H#, Zhu S#, Song C, Liu N, Kang J*. Cell Signal. 2012 Apr;24(4):961-8(代表作).
Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X*. J Biol Chem. 2010 Dec 3;285(49):38730-9.
Structural and mechanistic insights into Mps1 kinase activation.Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X*. J Cell Mol Med. 2009 Aug;13(8B):1679-94.
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Xu Q#, Zhu S#, Wang W, Zhang X, Old W, Ahn N, Liu X*. Mol Biol Cell. 2009 Jan;20(1):10-20(代表作).
Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. Zhu S, Wang W, Clarke DC, Liu X*. J Biol Chem. 2007 Jun 22;282(25):18327-38. (代表作)
以下为研究生期间的科研论文
Gang Cai, Songcheng Zhu, Xuejuan Wang and Weihong Jiang,Cloning, Sequence Analysis and Expression of the Gene Encoding a Novel Wide-spectrum Amidase Belonging to the Amidase Signature Superfamily from Achromobacter xylosoxidans. FEMS Microbiol Lett. 2005; 249(1): 15-21.
Gang Cai*, Songcheng Zhu*, Sheng Yang, Guoping Zhao and Weihong Jiang, Cloning, Overexpression, and Characterization of a Novel Thermostable Penicillin G Acylase from Achromobacter xylosoxidans, Applied and Environmental Microbiology, 2004; 70(5): 2764-70 *Co-first author.
Songcheng Zhu, Yunliu Yang, Guoping Zhao and Weihong Jiang, A rapid and specific method to screen environmental microorganisms for cephalosporin acylase activity, Journal of Microbiological Methods, July 2003; 54(1): 131-5.
Songcheng Zhu et al, Selection of a strain producing beta-lactam antibiotics acylases, Acta Microbiologica Sinica, Feb. 2003; 43(1): 79-86
Songcheng Zhu et al, The synthesis of 3-nitro–5-(6-bromo- hexanoylamino) benzoic acid and the studies on its use as indicator of cephalosporin–acylase– producing- microorganisms, Chinese Journal of Antibiotics, 1999; 24(3)