个人简介

1996年毕业于上海医科大学（现复旦大学医学院），获医学学士学位。1999年于上海医科大学（现复旦大学医学院）获医学硕士学位，2003年于德国吉森大学遗传所，获生物学博士学位。2004年-2007年在德国马普生化研究所进行博士后研究。2007年回国，2008年入选上海市浦江人才计划，任职于同济大学生命科学与技术学院、上海市信号转导与疾病研究重点实验室副教授，主要从事小分子化合物在诱导多能性干细胞中的作用及GPCR信号转导通路调控在神经退行性疾病中的作用及机制研究。先后主持和参加国家自然科学基金、科技部国际合作项目、科技部“973计划”及“国家重点研发计划“，学术成果发表于在APS、JAD、EMBOJ、JBC等国际学术期刊。

研究领域

1、细胞信号转导研究，衰老与阿尔茨海默症发病机制研究及相关创新药物发现 2、干细胞命运调控机制研究及相关小分子药物的发现

分子与细胞生物学，细胞信号转导、衰老与神经退行性疾病

近期论文

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Zeng P, Hua QH, Gong JY, Shi CJ, Pi XP, Xie X, Zhang R*.Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media. Acta Pharmacol Sin. 2021 Feb 5. Online ahead of print. PMID: 33547374 Li Y, Sun X, Liu H, Huang L, Meng G, Ding Y, Su W, Lu J, Gong S, Terstappen GC, Zhang R*, Zhang W. Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs. Neurosci Bull. 2019 Dec;35(6):996-1010. (*co-corresponding author） Cui X, Guo YE, Fang JH, Shi CJ, Suo N, Zhang R*, Xie X. Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination. Acta Pharmacol Sin. 2019 Nov;40(11):1386-1393. (*co-corresponding author) Su D, Wang M, Ye C, Fang J, Duan Y, Zhang Z, Hua Q, Shi C, Zhang L, Zhang R*, Xie X. One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor. Sci Rep. 2017 Mar 16;7:44476. （*co-corresponding author） Zhang L, Hua Q, Tang K, Shi C, Xie X, Zhang R*. CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells. Neuroscience.2016 Nov 19;337:88-97. Wang, Junjie; Wang, Zhilong; Zhang, Zhenghong; Hua, Qiuhong; Wang, Min; Shi, Changjie; Xue, Lei; *Zhang, Ru; *Xie, Xin. Methuselah regulates longevity via dTOR: a pathway revealed by small-molecule ligands. Journal of Molecular Cell Biology,2015, 7(3) :280-282.( *co-corresponding author) Ye C, Zhang Z, Wang Z, Hua Q, Zhang R*, Xie X. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. J Pharmacol Exp Ther. (2014) ;349(3):437-43.( *co-corresponding author) Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie. Proliferation rate of somatic cells affects reprogramming efficiency. The Journal of Biological Chemistry.(2013), 288(14):9767-9778( *co-corresponding author) Ru Zhang, Lihong Zhang, Xin Xie. iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacalogica Sinica，(2013) 34(6):765-76 Ru Zhang, Guizhen Xue, Shaodeng Wang, Lihong Zhang, Changjie Shi, Xin Xie. Novel Object Recognition as a Facile Behavior Test for Evaluating Drug Effects in A PP/PS1 Alzheimer’s Disease Mouse Model. Journal of alzheimer's disease, 31 (2012) 801–812 Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research, 23 (2012):131-41 Ru Zhang, Xin Xie. Tools for GPCR Drug Discovery. Acta Pharmacalogica Sinica，(2012) 33: 372-384 Koch H*, Zhang R*, Verdoodt B, Bailey A, Zhang CD, Yates 3rd JR, Menssen A, and Hermeking H. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 2007, 6(2): 205-217. ( *co-first author) Burke LJ*, Zhang R*, Bartkuhn M, Tiwari VK, Tavoosidana G, Kurukuti S, Weth C, Leers J, Galjart N, Ohlsson R, Renkawitz R. CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J. 2005, 24(18):3291-300. ( *co-first author) Zhang R, Burke LJ, Rasko J, Lobanenkov V, Renkawitz R. Dynamic association of the mammalian insulator protein CTCF with centrosomes and the midbody. Exp. Cell Res. 2004, 10;294(1):86-93.