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个人简介

张敬,女,博士,同济大学生命科学与技术学院教授。1990于东南大学医学院获学士学位,1996年于同济大学获硕士学位,2006年于第二军医大学获博士学位。现主要研究非编码RNA在胚胎干细胞、间充质干细胞、神经干细胞分化中的调控作用以及微量元素镍等环境污染物致癌的分子机制。已主持或参与国家自然科学基金项目、973项目、863项目、科技部国际合作项目、上海市自然科学基金、上海市科委中药现代化重点项目、中日横向合作项目等10余项科研项目。在国内外杂志上发表学术论文50余篇,主编教材1部,申请专利2项。

研究领域

1. non-coding RNA在干细胞分化中的调控机制 2. 微量元素镍等环境污染物致癌的分子机制

表观遗传学、分子生物学

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Jun Zhang,Jing Zhang* , Yang Zhou,You-jun Wu,,Lin Ma, Rui-jin Wang ,Sun-quan Huang ,Rong-rong Gao, Li-hong Liu ,Zhi-hua Shao,Hong-jun Shi,Li-ming Cheng and Long Yu . Novel Cerebellum-enriched miR-592 may play a role in Neural Progenitor Cell Differentiation and Neuronal Maturation through Regulating Lrrc4c and Nfasc in Rat.. Curr Mol Med. 2013,13(9) 1432-45 (* co-first author). Jing Zhang,Yang Zhou,You-Jun Wu, Meng-Jie Li,Rui-Jin Wang,Shun-Quan Huang, Rong-Rong Gao, Lin Ma, Hong-Jun Shi, Jun Zhang. Hyper-methylated miR-203 dysregulates ABL1 and contributes to thenickel-induced tumorigenesis. Toxicol Lett . 2013,223(1): 42–51 Jing Zhang, Yang Zhou, Lin Ma, Shunquan Huang, Ruijin Wang ,Rongrong Gao, Youjun Wu,Hongjun Shi,Jun Zhang. The Alteration of MiR-222 and Its Target Genes in Nickel-Induced Tumor. Biol Trace Elem Res 2013,152(2):267-274. Jing Zhang , Yang Zhou,Youjun Wu ,Lin Ma ,Yingying Fan ,Xuan Kang , Hongjun Shi , Jun Zhang*.Isolation and Characterization of a Novel Noncoding RNA from Nickel-Induced Lung Cancer. Biol Trace Elem Res .2012,150(1-3):258-263 Jing Zhang , Jun Zhang , Yingying Fan , Mengjie Li , Yang Zhou ,Zhihua Shao , Hong-jun Shi ,Ying Wang. Identification of differentially expressed genes in lung of nickel-exposed rats . Biol Trace Elem Res,2011,143(2):1007-1017. Jun Zhang ,Jing Zhang* , Li-hong Liu, Yang Zhou ,You-jun Wu, Yi-ping Li , Zhi-hua Shao , Meng-jiLi, Ying-ying Fan, and Hong-jun Shi. Effects of miR-541 on neurite outgrowth during neuronal differentiation .Cell Biochem Funct. 2011; 29(4):279-286. (* co-first author). ZHANG Jun, ZHANG Jing*, LI MengJie, Wu YouJun, FAN YingYing, ZHOU Yang, TAN LiLi, SHAO ZhiHua, SHI HongJun . Methylation of RARβ2, RASSF1A and CDKN2A Genes Induced by Nickel Subsulfide and Nickel-carcinogenesis in Rats. Biomed Environ Sci,2011,24(2):163-171 . (* co-first author). Jing Zhang, Jun Zhang , Youjun Wu, Yang Zhou,Zhihua Shao ,Xuan Kang, Lin Ma, Mengjie Li, Lihong Liu, and Hongjun Shi. Sez-6 May Play an Important Role in Neurite Outgrowth through the PKCg Signaling Pathways.Z NATURFORSCH C. 2011,66(11-12):614-620

学术兼职

中国营养学会微量元素专业委员会委员,上海市微量元素学会秘书长,上海市营养学会理事

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