个人简介

魏珂，同济大学生命科学与技术学院教授，附属东方医院再生医学研究所特聘研究员。本科毕业于清华大学生物科学与技术系，于美国加利福尼亚大学洛杉矶分校分子细胞综合生理专业获得博士学位，后在美国桑福德伯纳姆普利贝司医学研究所进行博士后科学研究。入选国家海外高层次人才青年项目，主持并参与多项国家自然金项目及科技部重点研发项目。主要研究方向为心脏发育与再生，通过高内涵筛选发现了影响心肌细胞增殖的旁分泌分子，miRNA以及小分子抑制剂；发现了心肌细胞成熟过程的新颖分子机制，为开发创新性针对心肌细胞再生的药物提供了新的方向。发表SCI论文30余篇，其中以第一作者及通讯作者发表包括Nature, Circulation, Nature Communications, Cardiovasc Res, Protein & Cell在内的论文16篇，并获得两项美国专利授权。

研究领域

1、心脏再生的机理的研究 2、针对心肌细胞的增殖与成熟的高内涵药物筛选 3、药物在动物心脏损伤模型中的应用

心脏发育与再生

近期论文

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Yansong Tang#, Mengying Feng#, Yang Su, Teng Ma, Hongjie Zhang, Hongchun Wu, Xiaoyu Wang, Shuyue Shi, Ying Zhang, Yawei Xu, Shijun Hu, Ke Wei*, Dachun Xu* “Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy” (2023) Circulation 147:1684–1704 (# Co-first authors; * corresponding authors) Jing Zhang#, Zhaohui Ouyang#, Limei Xia, Qi Wang, Feng Zheng, Kun Xu, Yuexian Xing, Ke Wei*, Shaolin Shi*, Chaojun Li*, Jingping Yang* “Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes” (2023) Cell Death Discovery 9(1), 11 (# Co-first authors; * corresponding authors) Hongjie Zhang#, Lijuan Pei#, Zhaohui Ouyang, Haocun Wang, Xin Chen, Kai Jiang, Shiqi Huang, Rui Jiang, Yaozu Xiang, Ke Wei* “AP-1 activation mediates postnatal cardiomyocyte maturation” (2022) Cardiovascular Research 119(2), 536-550 (# Co-first authors; * corresponding author) Lei Gao#, Hongjie Zhang#, Jingyi Cui, Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu*, Ke Wei*, Hongming Zhu* “Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair” (2021) Protein & Cell 12(2):152-157 (# Co-first authors; * corresponding authors) Ke Wei*, Vahid Serpooshan*, Cecilia Hurtado, Marta Diez-Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola & Pilar Ruiz-Lozano “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart” (2015) Nature 525: 479-485 (* Co-first authors)