王春光 - 同济大学 - 生命科学与技术学院

个人简介

1991年9月－1995年7月，吉林大学生物化学与分子生物学系，获学士学位 1995年9月－2000年7月，中科院生物物理所，获生物化学与分子生物学博士学位 2000年9月－2003年3月，中科院上海生化所，博士后 2003年4月－2006年3月，法国国家科研中心结构酶学和结构生物化学实验室（Laboratoire d'Enzymologie et Biochimie Structurales, CNRS），博士后 2006年5月至今，同济大学，研究员、博士生导师、蛋白质研究所副所长获奖 2005年获上海市科技进步一等奖 2006年入选上海市“曙光学者” 2007年获上海市“浦江人才”资助 2008年入选同济大学优秀青年教师 2009年入选教育部“新世纪优秀人才” 2011年获同济大学十大“我心目中的好导师”称号

研究领域

1. 微管作为一种重要的细胞骨架，参与细胞形状和极性维持、胞内物质运输和细胞分裂等重要的生理活动。微管的动态组装和稳定性维持受到很多因素的调节，微管状态紊乱与癌症、神经退行性疾病等密切相关。我们主要研究各种调控微管组装的蛋白质和小分子化合物的作用机理，以理解微管的调控过程及相关疾病的发生原因和药物治疗机理。 2. 动物多肽神经毒素是自然界中产毒动物经过亿万年的进化而形成的具有高活性和高选择性的神经毒素，可以作为神经生物学研究的有力工具和神经系统疾病的治疗药物。芋螺毒素因为其结构和功能的高度多样性而倍受关注，也是我们目前的主要研究对象。

近期论文

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Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang*, Benoit Gigant*. Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin. Nat. Commun. 2017, 8(1): 70. Longjin Yang, Han-Shen Tae, Zhou Fan, Xiaoxia Shao, Shaoqiong Xu, Suwen Zhao, David J. Adams*, Chunguang Wang*. A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αD-conotoxin GeXXA. Mar. Drugs. 2017, 15(6). 164. Shantong Jiang, Han-Shen Tae, Shaoqiong Xu, Xiaoxia Shao, David J. Adams*, Chunguang Wang*. Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor. Mar. Drugs. 2017, 15(6). 170. Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun, Xuejiao Hong, Ying Cao, Chunguang Wang*. Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein. Cell Cycle. 2016, 15(17): 2367-2375. Shaoqiong Xu, Tianlong Zhang, Shiva N. Kompella, Mengdi Yan, Aiping Lu, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, David J. Adams*, Jianping Ding*, Chunguang Wang*. Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors. Sci. Rep. 2015, 5: 14261. Weiyi Wang, Ting Shen, Raphael Guerois, Fuming Zhang, Hureshitanmu Kuerban, Yuncong Lv, Benoît Gigant*, Marcel Knossow*, and Chunguang Wang*. New insights into the coupling between microtubule depolymerization and ATP hydrolysis by kinesin-13 protein Kif2C. J. Biol. Chem. 2015, 290 (30): 18721-18731. Weiyi Wang, Luyan Cao, Chunguang Wang, Benoit Gigant, Marcel Knossow*. Kinesin, 30 years later: Recent insights from structural studies. Protein Sci. 2015, 24(7): 1047-1056. Luyan Cao, Weiyi Wang, Qiyang Jiang, Chunguang Wang*, Marcel Knossow*, Benoit Gigant*. The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement. Nat. Commun. 2014, 5: 5364. Aiping Lu, Longjin Yang, Shaoqiong Xu, and Chunguang Wang*. Various conotoxin diversifications revealed by a venomic study of Conus flavidus. Mol. Cell Proteomics, 2014, 13(1): 105-118. Wentao Peng, Zhijie Lin, Weirong Li, Jing Lu, Yueyuan Shen*, Chunguang Wang*. Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein. J. Biol. Chem. 2013, 288: 29305-29312. Benoît Gigant, Weiyi Wang, Birgit Dreier, Qiyang Jiang, Ludovic Pecqueur, Andreas Plückthun, Chunguang Wang*, Marcel Knossow*. Structure of a kinesin–tubulin complex and implications for kinesin motility. Nat. Struct. Mol. Biol. 2013, 20(8): 1001-1007. Maorong Wen, Chunguang Wang*. The nucleotide cycle of spastin correlates with its microtubule-binding properties. FEBS J. 2013, 280: 3868-3877. Shaoqiong Xu, Hua Li, Xiaoxia Shao, Chongxu Fan, Bryan Ericksen, Jinsong Liu, Chengwu Chi*, Chunguang Wang*. Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue Virus NS2B-NS3 protease. J. Med. Chem. 2012, 55(15): 6881-6887. Ludovic Pecqueur, Christian Duellberg, Birgit Dreier, Qiyang Jiang, Chunguang Wang, Andreas Pluckthun, Thomas Surrey, Benoit Gigant, Marcel Knossow*. A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A 2012, 109(30): 12011-12016. Weiyi Wang, Qiyang Jiang, Manuela Argentini, David Cornu, Benoît Gigant, Marcel Knossow*, Chunguang Wang*. Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J. Biol. Chem. 2012, 287(18): 15143-15153. Mingyu Ye, Keith K. Khoo, Shaoqiong Xu, Mi Zhou, Nonlawat Boonyalai, Matthew A. Perugini, Xiaoxia Shao, Chengwu Chi, Charles A. Galea, Chunguang Wang*, and Raymond S. Norton*. A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. J. Biol. Chem. 2012, 287(18): 14973-14983. Anthony Cormier, Marcel Knossow, Chunguang Wang and Benoit Gigant. The binding of vinca domain agents to tubulin: structural and biochemical studies. Methods in Cell Biology. 2010, 95: 369-386. Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du and Chunguang Wang*. Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. 2008, 275: 1976-1987. Chuanguang Wang, Anthony Cormier, Benoit Gigant, Marcel Knossow. Insight into the GTPase activity of tubulin from complexes with stathmin-like domains. Biochemistry, 2007, 46: 10595-10602. Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel, Marcel Knossow. Structural basis for the regulation of tubulin by vinblastine. Nature 2005, 435(7041): 519-522. Chunguang Wang, Nicolas Gilles, Alain Hamon, Frédéric Le Gall, Maria Stankiewicz, Marcel Pelhate, Yumei Xiong, Dacheng Wang, Chengwu Chi. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry 2003, 42(16): 4699-4708.