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Liu G*, Li Y*, Li M, Li S, He Q, Liu S, Su Q, Chen X, Xu M, Zhang ZN#, Shao Z#, Li W#. Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells. Sci Adv.1.2023 May 24;9(21):eadg2183.
Yuan F*, Li Y*, Hu R*, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z#, Zhang ZN#, Li W#. Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule. Mol Psychiatry.2023 Feb 7.
Su Y*, Sun J1*, Li X, Qin D, Chen X, Pei Y, Zhang ZN, He Q, Fu Z, Sheng Z, Dong Y, Deng Q, Wang H, Le R#, Gao S#, Li W#. CD47 blocking antibody confers exercise effects by promoting skeletal muscle-specific AMPK activation.Cell Metab. (After review for resubmission)
Ma Q*, Xiao Y*, Xu W*, Wang M, Li S, Yang Z, Xu M, Zhang T, Zhang ZN, Hu R, Su Q, Yuan F, Xiao T, Wang X, He Q, Zhao J, Chen ZJ, Sheng Z, Chai M, Wang H, Shi W, Deng Q#, Cheng X#, Li W#. ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes. Nat Commun. 2022 Jul 16;13(1):4142.
本论文获得Nature Review Endocrinology及Science Signaling的亮点评述，Nature Reviews Endocrinology杂志指出“这一工作证明了一种再生胰岛β细胞的新的途径，通过胰岛β细胞的再生来治疗糖尿病的前景已不再遥远”。同时Science signaling杂志也以此工作为亮点，指出该工作“促进了β细胞的成熟和功能，证明了再生的细胞可以长期稳定存在”。
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