康九红 - 同济大学 - 生命科学与技术学院

个人简介

康九红教授，1998年获兰州大学细胞生物学专业理学博士学位，先后在日本大阪大学医学院谷口教授和中国科学院生化细胞所裴钢院士实验室，从事博士后研究。2009年起任同济大学生命科学与技术学院特聘教授。 2006年获得国家杰出青年基金资助。2009年和2010年分别获得上海市自然科学一等奖和教育部自然科学一等奖。2009年和2011年分别获得上海市科技领军人才和优秀学科带头人称号。2011年作为负责人获得教育部创新团队发展计划资助；同年，当选海市首届十大校园“科研新星”和上海市杨浦区第十五届人大代表。2012年当选同济大学医学与生命科学学部“我心目中的好导师”。2013年当选科技部中青年科技创新领军人才，并获国务院政府特殊津贴。2014年获国家高层次人才特殊支持计划领军人才，同济大学师德师风优秀教师和育才教育二等奖。2011年、2016年和2021年作为“首席科学家”获得科技部重大研究计划项目，2016年获上海市育才奖，2017年获同济大学“立德树人”优秀教师，2019年获批国家干细胞转化资源库，2020年获宝钢优秀教师奖。兼任中国细胞生物学会医学细胞生物学会理事，中国解剖学会医学发育生物学分会副理事长，中国医药生物技术协会神经修复和再生分会副主任委员。在Cell、Nature、Cell Stem Cell等国际著名学术期刊发表论文百余篇，SCI他引5000余次。

研究领域

1）干细胞全能性形成、基因组稳定性及向神经和心肌定向分化的表观遗传机制（非编码RNA、组蛋白修饰和DNA甲基化等） 2）肿瘤形成的信号转导、免疫和表观遗传机制

干细胞与表观遗传学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xi J, Xu Y, Guo Z, Li J, Wu Y, Sun Q, Wang Y, Chen M, Zhu S, Bian S, Kang J#. LncRNA SOX1-OT V1 acts as a decoy of HDAC10 to promote SOX1-dependent hESC neuronal differentiation. EMBO Rep. 2022; 23(2):e53015. Xu Y, Xi J, Wang G, Guo Z, Sun Q, Lu C, Ma L, Wu Y, Jia W, Zhu S, Guo X, Bian S, Kang J#. PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiation. Nucleic Acids Res. 2021; 49(4):1935-50. Chen W, Liu N, Shen S, Zhu W, Qiao J, Chang S, Dong J, Bai M, Ma L, Wang S, Jia W, Guo X, Li A, Xi J, Jiang C, Kang J#. Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. Cell Rep. 2021; 37(5):109912. Wang G, Yu J, Yang Y, Liu X, Guo X, Duan T#, Lu C#, Kang J#. Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction. Clin Transl Med. 2020; 9:9. Qiao J, Zhao J, Chang S, Sun Q, Liu N, Dong J, Chen Y, Yang D, Ye D, Liu X, Yu Y, Chen W, Zhu S, Wang G, Jia W, Xi J#, Kang J#. MicroRNA-153 improves the neurogenesis of neural stem cells and enhances the cognitive ability of aged mice through the notch signaling pathway. Cell Death Differ. 2020; 27(2):808-25. Yu Y, Jia W, Lyu Y, Su D, Bai M, Shen J, Qiao J, Han T, Liu W, Chen J, Chen W, Ye D, Guo X, Zhu S, Xi J, Zhu R, Wan X, Gao S, Zhu J, Kang J#. Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation. Cell Discov. 2019; 5:47. Zhao J, Tang M, Cao J, Ye D, Guo X, Xi J, Zhou Y, Xia Y, Qiao J, Chai R, Yang X#, Kang J#. Structurally tunable reduced graphene oxide substrate maintains mouse embryonic stem cell pluripotency. Adv Sci (Weinh). 2019; 6(12):1802136. Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, Lu C, Jia W, Xi J, Zhu S, Jiapaer Z, Wan X, Liu Z, Gao S, Kang J#. A Linc1405/Eomes complex promotes cardiac mesoderm specification and cardiogenesis. Cell Stem Cell. 2018; 22(6):893-908. Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, Liu Z, Jiapaer Z, Wan X, Wang G, Chen W, Zhu S, Jiang C, Shi W#, Kang J#. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018; 46(12):6026-40. Liu Z, Tang M, Zhao J, Chai R#, Kang J#. Looking into the future: toward advanced 3D biomaterials for stem-cell-based regenerative medicine. Adv Mater. 2018; 30(17):e1705388. Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, Leng Y, Wan X, Kang J#. N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential. Nucleic Acids Res. 2018; 46(8):3906-20. Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J#. Sirt6 promotes DNA end joining in iPSCs derived from old mice. Cell Rep. 2017; 18(12):2880-92. Wei T, Chen W, Wang X, Zhang M, Chen J, Zhu S, Chen L, Yang D, Wang G, Jia W, Yu Y, Duan T, Wu M, Liu H, Gao S, Kang J#. An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. Nucleic Acids Res. 2015; 43(11):5409-22. Wang G, Guo X, Hong W, Liu Q, Wei T, Lu C, Gao L, Ye D, Zhou Y, Chen J, Wang J, Wu M, Liu H, Kang J#. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. PNAS 2013; 110(8):2858-63. Guo X, Liu Q, Wang G, Zhu S, Gao L, Hong W, Chen Y, Wu M, Liu H, Jiang C, Kang J#. microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res. 2013; 23:142-56. Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Zhang X, Wang F, Yang R, Fan F, Pei G, Ma L. A nuclear function of beta-arrestin 1 in GPCR Signaling: regulation of histone acetylation and gene transcription. Cell 2005; 123:833-4.