个人简介

1995 年毕业于天津南开大学，获学士学位。1998年毕业于天津南开大学，获硕士学位。2004年毕业于美国爱荷华州州立大学，获遗传学博士学位，并辅修生物信 息学和计算机科学。毕业后先后在美国冷泉港实验室、弗吉尼亚联邦大学、宾夕法尼亚州州立大学进行博士后研究。2009年应聘为同济大学特聘教授。

研究领域

(1) 早期胚胎发育中的表观遗传调控机制 (2) 细胞命运决定与转变中的表观遗传调控机制 (3) 癌症发生、发展、转移与耐药的表观遗传调控作用及机制

基因在时空上的精确表达受各种表观遗传因素的调控。基因表达差异导致不同的表型，如高矮胖瘦、健康与生病。目前研究较多的表观遗传因素有DNA甲基化、组蛋白修饰、核小体定位、染色质高级结构、非编码RNA、RNA修饰与编辑等。我们课题组聚焦前四种表观四会因素在早期胚胎发育、细胞命运决定、重大疾病中的表观遗传调控机制。 一、早期胚胎发育中的表观遗传调控机制 精卵结合经过卵裂、增殖、分化，形成形态各一功能迥异的不同细胞。这些细胞组合形成组织，多种组织再进一步形成器官，最后形成一个个体。透过现象看本质，这些形态各一功能迥异的细胞都来自一个受精卵，拥有相同的一套基因。但在胚胎发育过程中，相同的一套基因受到精确的表观遗传调控，在时空上表达不同，从而形成形态各一功能迥异的不同组织细胞。在早期胚胎发育中，最初由卵子中带来的RNA与蛋白支撑受精卵发育，很快过渡到由合子基因组启动自身转录表达来支撑受精卵后续的发育，这一过程叫合子基因组启动（也叫母源到合子转变），它对早期胚胎发育至关重要，也受到精确的表观遗传调控。此外，在整个胚胎发育过程中，表观遗传基因调控出现异常，重则导致胚胎发育停滞，轻则导致出生缺陷，给社会与个人家庭带来极大负担与痛苦。我们通过正常受精与体细胞核移植的小鼠早期发育各阶段胚胎，利用多组学技术，通过生物信息学分析与实验验证，研究早期胚胎发育过程中的表观修饰图谱变化，鉴定关键蛋白因子，并探索其对早期胚胎发育的表观遗传调控机制。研究成果对理解和预防发育异常相关疾病有重大意义，在辅助生殖、畜牧业中优良品种及濒危物种的保种育种有重要应用价值。 二、细胞命运决定与转变中的表观遗传调控机制 胚胎干细胞具有全能性，能分化成生物体的各种细胞。反之，经过体细胞重编程，可把已分化的体细胞诱导成具有全/多能性干细胞。另外，对少数类型细胞，通过转分化技术，可直接把一种类型体细胞转变成另一种类型体细胞，即细胞转分化。在上述细胞命运决定与转变过程中，表观遗传调控发挥重要作用。我们课题组利用成熟的体外细胞分化平台、体细胞重编程技术与转分化技术，用二代测序技术测定不同阶段的基因表达、各种表观修饰、关键转录因子全基因组结合位点，通过生物信息学分析与实验验证，探索细胞命运决定与转变中的表观遗传调控机制。研究成果为高效获得高质量的干细胞、前体细胞、特定分化细胞提供理论依据与技术支撑，促进干细胞在基础研究与临床治疗中的应用。 三、癌症发生、发展、转移与耐药的表观遗传调控作用及机制 大量研究表明，许多重大疾病如癌症、老年痴呆等神经退行性疾病都与表观遗传基因调控紊乱有密切关系。癌症是最难治疗的疾病之一，严重危害人类健康。癌症之所以难治疗，是其具有转移与耐药的特性。二者皆与表观遗传调控有密切关系。我们课题组通过体外细胞水平、小鼠体内、与临床样本三个层次，探究癌症干细胞干性维持、癌细胞转移与耐药的表观遗传调控机制，鉴定关键蛋白因子与基因组位点，作为潜在的治疗与药物靶点。研究成果可改善我们对癌症发生、发展、转移与耐药调控机制的理解，最终促进临床上对癌症的诊断与治疗。

近期论文

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Wang, Mingzhu, Zhao, Kun, Liu, Meng, Wang, Mengting, Qiao, Zhibin, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2022). BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding. PROTEIN & CELL. Liu, Meng, Guo, Gangqiang, Qian, Pengge, Mu, Jianbing, Lu, Binbin, ..., Yuan, Jing, Jiang, Cizhong, Zhang, Qingfeng (2022). 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Liu, Wenju, Shen, Junwei, Li, Yanfei, Wu, Jiawen, Luo, Xiaoli, ..., Zhang, Xiaobai, Jiang, Cizhong, Li, Jue (2021). Pyroptosis inhibition improves the symptom of acute myocardial infarction. CELL DEATH & DISEASE. Zhao, Yuemeng, Wang, Fei, Wang, Changhong, Zhang, Xiaobai, Jiang, Cizhong, Ding, Feng, Shen, Li, Zhang, Qingfeng (2021). 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Hu, Xinjie, Zheng, Weisheng, Zhu, Qianshu, Gu, Liang, Du, Yanhua, ..., Cheung, Belamy B., Qiu, Andong, Jiang, Cizhong (2019). Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma. FRONTIERS IN GENETICS. Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Wang, Ruiqin, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2019). Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells. BIOTECHNOLOGY LETTERS. Chen, Xiaolong, Ye, Youqiong, Gu, Liang, Sun, Jin, Du, Yanhua, ..., Li, Wei, Zhang, Xiaobai, Jiang, Cizhong (2019). H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development. GENOMICS PROTEOMICS & BIOINFORMATICS. Zhang, Qitong, Zhang, Qingquan, Jiang, Xue, Ye, Youqiong, Liao, Huimin, ..., Chen, Yihan, Liang, Xingqun, Sun, Yunfu (2019). Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. THERANOSTICS. Tang, Wei, Guo, Ren, Shen, Shi-jun, Zheng, Yang, Lu, Yu-ting, ..., Cui, Xue, Jiang, Ci-zhong, Xie, Xin (2019). Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor. ACTA PHARMACOLOGICA SINICA. Chen, Yu, Zhang, Haiping, Xu, Zhu, Tang, Huanyin, Geng, Anke, ..., Jiang, Ying, Gorbunova, Vera, Mao, Zhiyong (2019). A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. NUCLEIC ACIDS RESEARCH. Zhang, Qingquan, Huang, Ru, Ye, Youqiong, Guo, Xiaoxia, Lu, Jun, ..., Jiang, Cizhong, Liang, Xingqun, Sun, Yunfu (2018). Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. CELL DEATH & DISEASE. Zhu, Fugui, Zhu, Qianshu, Ye, Dan, Zhang, Qingquan, Yang, Yiwei, ..., Jiang, Cizhong, Shi, Weiyang, Kang, Jiuhong (2018). Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. NUCLEIC ACIDS RESEARCH. He, Wenteng, Zhang, Xiaobai, Zhang, Yalin, Zheng, Weisheng, Xiong, Zeyu, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2018). Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b. STEM CELL REPORTS. Ping, Wangfang, Hu, Jian, Hu, Gongcheng, Song, Yawei, Xia, Qing, ..., Gong, Shixin, Jiang, Cizhong, Yao, Hongjie (2018). Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. CELL DEATH & DISEASE. Hu, Jian, Gu, Liang, Ye, Youqiong, Zheng, Meizhu, Xu, Zhu, ..., Zhang, Xiaobai, Weng, Zhiping, Jiang, Cizhong (2018). Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development. 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Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Li, Jie, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2017). Genetic analysis of heterogeneous sub-clones in recombinant Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. Ye, Youqiong, Li, Min, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2017). Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. CELL DEATH AND DIFFERENTIATION. Jiang Cizhong, Gao Shaorong (2017). Chromatin remodeling and its epigenetic regulatory mechanisms in cell fate transition. Chinese Bulletin of Life Sciences. Jin, Jiali, Liu, Jian, Chen, Cong, Liu, Zhenping, Jiang, Cong, ..., Ge, Xin, Xie, Xin, Wang, Ping (2016). The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. NATURE COMMUNICATIONS. Li, Dong, Shi, Jiejun, Du, Yanhua, Chen, Kaiming, Liu, Zhenping, ..., Gu, Hua, Jiang, Cizhong, Fang, Jianmin (2016). Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. PLOS ONE. Yang, Yuanyuan, Zhang, Xiaobai, Yi, Li, Hou, Zhenzhen, Chen, Jiayu, ..., Jiang, Cizhong, Wang, Yixuan, Gao, Shaorong (2016). Naive Induced Pluripotent Stem Cells Generated From beta-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9 (vol 5, pg 8, 2016). STEM CELLS TRANSLATIONAL MEDICINE. Lu, Ping, Chen, Xiaolong, Feng, Yun, Zeng, Qiao, Jiang, Cizhong, Zhu, Xianmin, Fan, Guoping, Xue, Zhigang (2016). Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation. SCIENCE CHINA-LIFE SCIENCES. Chen, Jun, Chen, Xiaolong, Li, Min, Liu, Xiaoyu, Gao, Yawei, ..., Wang, Hong, Jiang, Cizhong, Gao, Shaorong (2016). Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. CELL REPORTS. Li, Hongwen, Chen, Kaiming, Wang, Zhe, Li, Dong, Lin, Jiannan, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2016). Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production. MOLECULAR BIOSYSTEMS. Shi, Jiejun, He, Jiangtu, Lin, Jing, Sun, Xin, Sun, Fenyong, Ou, Chao, Jiang, Cizhong (2016). Distinct response of the hepatic transcriptome to Aflatoxin B-1 induced hepatocellular carcinogenesis and resistance in rats. SCIENTIFIC REPORTS. Zhang, Shiping, Guo, Xiaowei, Chen, Changyan, Chen, Yujun, Li, Jikai, ..., Jiang, Cizhong, Li, Wenzhe, Xue, Lei (2016). dFoxO promotes Wingless signaling in Drosophila. SCIENTIFIC REPORTS. Ye, Youqiong, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2016). Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos. SCIENTIFIC REPORTS. Men, Hewei, Zheng, Weisheng, Li, Junjie, Jiang, Cizhong, Cai, Jinzhen, Li, Jiang, Teng, Dahong (2015). The microRNA Signatures in Mouse Liver Ischemia Reperfusion Injury. TRANSPLANTATION. Shen, Junwei, Jia, Wenwen, Yu, Yangyang, Chen, Jie, Cao, Xinkai, ..., Duan, Tao, Jiang, Cizhong, Kang, Jiuhong (2015). Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling. STEM CELLS. Huang, Kaimeng, Zhang, Xiaobai, Shi, Jiejun, Yao, Mingze, Lin, Jiannan, ..., Jiang, Cizhong, Pei, Duanqing, Yao, Hongjie (2015). Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells. SCIENTIFIC REPORTS. Fu, Yanbin, Huang, Chenwen, Xu, Xinxiu, Gu, Haifeng, Ye, Youqiong, Jiang, Cizhong, Qiu, Zilong, Xie, Xin (2015). Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. CELL RESEARCH. Li, Dong, Xie, Kun, Ding, Guitao, Li, Jie, Chen, Kaiming, ..., Qian, Jie, Jiang, Cizhong, Fang, Jianmin (2014). Tumor resistance to anti-VEGF therapy through up-regulation of VEGF-C expression. 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Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC BIOLOGY. Yin, Rong, Gu, Liang, Li, Min, Jiang, Cizhong, Cao, Tongcheng, Zhang, Xiaobai (2014). Gene Expression Profiling Analysis of Bisphenol A-Induced Perturbation in Biological Processes in ER-Negative HEK293 Cells. PLOS ONE. Huang, Biao, Jiang, Cizhong, Zhang, Rongxin (2014). Epigenetics: the language of the cell?. EPIGENOMICS. Shi, Jiejun, Zheng, Meizhu, Ye, Youqiong, Li, Min, Chen, Xiaolong, ..., Sun, Jin, Zhang, Xiaobai, Jiang, Cizhong (2014). Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. NUCLEIC ACIDS RESEARCH. Chen, Guangfeng, Shi, Xiujuan, Sun, Chen, Li, Min, Zhou, Qing, ..., Jiang, Cizhong, Ying, Ming, Liu, Xiaoqing (2013). VEGF-Mediated Proliferation of Human Adipose Tissue-Derived Stem Cells. PLOS ONE. Zhang, Xiaobai, Shen, Yuefeng, Ding, Guitao, Tian, Yi, Liu, Zhenping, Li, Bing, Wang, Yun, Jiang, Cizhong (2013). TFPP: An SVM-Based Tool for Recognizing Flagellar Proteins in Trypanosoma brucei. PLOS ONE. Dai, Xiuqin, Jiang, Weijian, Zhang, Qingquan, Xu, Lian, Geng, Peng, ..., Sun, Yunfu, Chen, Ju, Liang, Xingqun (2013). Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC BIOLOGY. Shi, Jiejun, Hu, Jian, Zhou, Qing, Du, Yanhua, Jiang, Cizhong (2013). PEpiD: A Prostate Epigenetic Database in Mammals. PLOS ONE. Guo, Xudong, Liu, Qidong, Wang, Guiying, Zhu, Songcheng, Gao, Longfei, ..., Liu, Houqi, Jiang, Cizhong, Kang, Jiuhong (2013). microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. CELL RESEARCH. Tang, Yitao, Dong, Shan, Cao, Xinkai, Zhou, Qing, Ding, Guitao, Jiang, Cizhong (2013). H2A.Z Nucleosome Positioning Has No Impact on Genetic Variation in Drosophila Genome. PLOS ONE. Bao, Jianqiang, Li, Ding, Wang, Li, Wu, Jingwen, Hu, Yanqin, ..., Jiang, Cizhong, Yan, Wei, Xu, Chen (2012). MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY. Venters, Bryan J., Wachi, Shinichiro, Mavrich, Travis N., Andersen, Barbara E., Jena, Peony, ..., Jiang, Cizhong, Hemeryck-Walsh, Christine, Pugh, B. Franklin (2011). A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in Saccharomyces. MOLECULAR CELL. Zhao, Zhongming, Jiang, Cizhong (2010). Features of Recent Codon Evolution: A Comparative Polymorphism-Fixation Study. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. Jiang, Cizhong, Pugh, B. Franklin (2009). Nucleosome positioning and gene regulation: advances through genomics. NATURE REVIEWS GENETICS. Koerber, R. Thomas, Rhee, Ho Sung, Jiang, Cizhong, Pugh, B. Franklin (2009). Interaction of Transcriptional Regulators with Specific Nucleosomes across the Saccharomyces Genome. MOLECULAR CELL. Jiang, Cizhong, Pugh, B. Franklin (2009). Identification and Nomenclature of the Consensus Nucleosomes Across the Yeast Genome. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. Jiang, Cizhong, Pugh, B. Franklin (2009). A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome. GENOME BIOLOGY. Mavrich, Travis N., Jiang, Cizhong, Ioshikhes, Ilya P., Li, Xiaoyong, Venters, Bryan J., ..., Gilmour, David S., Albert, Istvan, Pugh, B. Franklin (2008). Nucleosome organization in the Drosophila genome. NATURE. Albert, Istvan, Wachi, Shinichiro, Jiang, Cizhong, Pugh, Franklin (2008). GeneTrack - a genomic data processing and visualization framework. BIOINFORMATICS. Mavrich, Travis N., Ioshikhes, Ilya P., Venters, Bryan J., Jiang, Cizhong, Tomsho, Lynn P., ..., Schuster, Stephan C., Albert, Istvan, Pugh, B. Franklin (2008). A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. GENOME RESEARCH. Zhao, Zhongming, Jiang, Cizhong (2007). Methylation-dependent transition rates are dependent on local sequence lengths and genomic regions. MOLECULAR BIOLOGY AND EVOLUTION. Jiang, Cizhong, Han, Leng, Su, Bing, Li, Wen-Hsiung, Zhao, Zhongming (2007). Features and trend of loss of promoter-associated CpG islands in the human and mouse genomes. MOLECULAR BIOLOGY AND EVOLUTION. Jiang, Cizhong, Zhao, Zhongming (2006). Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms. GENOMICS. Jiang, Cizhong, Zhao, Zhongming (2006). Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome. BMC GENOMICS. Boddu, J, Jiang, CH, Sangar, V, Olson, T, Peterson, T, Chopra, S (2006). Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis. PLANT MOLECULAR BIOLOGY. Seo, Daekwan, Jiang, Cizhong, Zhao, Zhongming (2006). A novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions. BMC GENOMICS. Jiang, CH, Gu, JY, Chopra, S, Gu, X, Peterson, T (2004). Ordered origin of the typical two- and three-repeat Myb genes. GENE. Jiang, CZ, Gu, X, Peterson, T (2004). Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp indica. GENOME BIOLOGY. Jiang, CZ, Song, WQ, Li, XL, Chen, RY (1998). Studies on microdissection and microcloning of the rye chromosome 1R. ACTA BOTANICA SINICA.