个人简介

2011年毕业于中国海洋大学，获学士学位；2017年毕业于中国科学院上海生物化学与细胞生物学研究所，获博士学位。2017至2022年在美国耶鲁大学医学院从事博士后研究。2022年12月起任同济大学特聘研究员，博士生导师。2023年2月起任同济大学附属东方医院特聘研究员。 研究工作荣获细胞出版社2014中国年度论文、2017中国十大医学进展、2018年上海市科学技术奖一等奖（排名第四）。博士后期间获得耶鲁大学医学院James Hudson Brown - Alexander B. Coxe Fellowship和2021美国血液学学会学者奖（ASH Scholar Award）资助。2022年入选上海市“海外高层次人才引进计划”。

研究领域

造血干细胞可以分化为造血系统各个谱系的成熟血细胞，其发育成熟过程受到严格的调控。特定的基因突变会引起造血干/祖细胞发育异常，进而导致白血病（leukemia）、骨髓异常增生综合征（MDS）等血液疾病。大规模病人样本测序揭示了表观遗传学调控和RNA转录后修饰在细胞命运调控中的重要作用，以及相应调控因子作为药物靶点的可能性。我们实验室的前期研究揭示了RNA修饰抑制双链RNA形成，维持正常免疫反应和造血发育过程的机制，从而将造血干细胞发育过程与天然免疫和能量代谢相联系。我们目前正在探索新型RNA修饰对于造血发育过程的调控作用，以及治疗血液疾病的新方案。 研究内容包括： 1. RNA修饰对造血发育过程的调控作用 2. 炎症反应对血液再生和细胞衰老的影响 3. 能量代谢调控在血液疾病治疗中的作用

血液发育与疾病的调控机制

近期论文

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一作/通讯文章 Gbyli R#, Song Y#*, Liu W#, Gao Y#, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S*. In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. Leukemia 2022;36:1313-1323. Gao Y, Chen S, Halene S*, Tebaldi T*. Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq. STAR Protocols 2021;2:100366. Vasic R#*, Gao Y#, Liu C#, Halene S*. The role of RNA epigenetic modification in normal and malignant hematopoiesis. Curr Stem Cell Rep 2020;6:144-155. Gao Y#*, Vasic R#, Song Y#, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA*, Li HB*, Tebaldi T*, Halene S*. m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020;52:1007-1021.e8. (Recommended by FacultyOpinions) Gao Y#, Zhang X#, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G*, Hui L*. Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor. Stem Cell Reports 2017;9:1813-1824. Shi XL#, Gao Y#, Yan Y#, Ma H#, Sun L#, Huang P#, Ni X, Zhang L, Zhao X, Ren H, Hu D, Zhou Y, Tian F, Ji Y, Cheng X, Pan G*, Ding YT*, Hui L*. Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Research 2016;26:206-216. Huang P#, Zhang L#, Gao Y#, He Z#, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y, Lai D, Hu Z, Chen L, Zhang Y, Cheng X, Ma X, Pan G, Wang X, Hui L*. Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell Stem Cell 2014;14:370-84. (Previewed by Cell Stem Cell，Recommended by F1000Prime，细胞出版社2014中国年度论文) 高义萌, 孙露露, 惠利健. 生物人工肝研究进展. 生命科学 2016;28:915-920. 高义萌, 惠利健. 细胞命运转变——癌化和转分化的研究. 中国细胞生物学学报 2014;36:713-716. 共同作者文章 Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell RA*, Li HB*. RNA m(6)A demethylase ALKBH5 regulates the development of gammadelta T cells. Proc Natl Acad Sci U S A 2022;119:e2203318119. Biancon G#*, Joshi P#, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T*, Halene S*. Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies. Molecular Cell 2022;82:1107-1122.e7. Song Y#, Shan L#*, Gbyli R#, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S*, Flavell RA*. Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells. Science 2021;371:1019-1025. (Recommended by FacultyOpinions) Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA*, Halene S*. A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies. Nature Communictions 2019;10:366. Liu LP#, Li YM#*, Guo NN, Li S, Ma X, Zhang YX, Gao Y, Huang JL, Zheng DX, Wang LY, Xu H, Hui L*, Zheng YW*. Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation. Cell Reports 2019;27:455-466.e1-e5. Ji S#, Zhu L#, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G*, Hui L*. Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Research 2017;27:642-656. (Previewed by Cell Research) Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Scholer HR, Han DW*. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell Reports 2016;15:814-829.