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个人简介

学习经历 1989-1993 山东农业大学 学士学位 1993-1996 中国农业大学 硕士学位 1996-2000 中国科学院动物研究所 博士学位 工作经历 1998-2000 美国布朗大学医学院 研究助理、联合培养博士 2000-2002 英国罗斯林研究所 博士后(师从“克隆羊之父”伊恩威尔穆特教授) 2002-2004 美国坦普尔大学医学院 博士后 2004-2005 美国康涅狄格大学 助理教授 2005-2013 北京生命科学研究所 研究员、高级研究员 2013-至今 同济大学生命科学与技术学院 特聘教授、院长 科研获奖 2023年获全国创新争先奖 2022年获上海市自然科学奖一等奖(第一完成人) 2021年获中国细胞生物学学会杰出成就奖 2020年获国家自然科学奖二等奖(第一完成人) 2019年获教育部高等学校科学研究优秀成果奖自然科学一等奖(第一完成人) 2015年获谈家桢生命科学创新奖 2014年获国家自然科学奖二等奖(第四完成人) 2011年获周光召基金会杰出青年基础科学奖 2009年获药明康德生命化学研究奖 教学获奖 2022年获上海市教学成果特等奖(第二完成人) 2022年获全国高校黄大年式教师团队(干细胞生物学教师团队,团队负责人)

研究领域

胚胎发育与多能干细胞 主要从事早期胚胎发育与体细胞重编程的表观遗传调控机制研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Liu X, Wang C, Liu W, Li J, Li C, Kou X, Chen J, Zhao Y, Gao H, Wang H, Zhang Y*, Gao Y*, Gao S*. (2016) Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature 537(7621):558-562. (View & News by Nature) Kang L, Wang J, Zhang Y, Kou Z, Gao S*. (2009) iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2):135-138. (Highlighted by Nature, Nature China; Selected as “Must Read” by Faculty 1000; Featured in TIME Magazine, Washington Post, Wall Street Journal, Xinhua News, USA Today, The Scientist, The Economist, ABC News, The Independent, Scientific America etc.) Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S*, Zhu B*. (2012) Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337(6097):971-5. (Previewed by Science) Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhan Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T*, Gao S*. (2013) Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 12(4):453-69. (Cover Story; Previewed by Cell Stem Cell; Selected as Best of 2013 by Cell Stem Cell) Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui X, Zhang L, Zhao X, Liu Q, He P, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He Y, Li X, Gao S*, Gao Y*, He C*. (2022) FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science 376(6596):968-973. Xu R, Li S, Wu Q, Li C, Jiang M, Guo L, Chen M, Yang L, Dong X, Wang H, Wang C*, Liu X*, Ou X*, Gao S*. (2022)Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. Cell Stem Cell 29(7):1051-1066. (Cover Story; Previewed by Cell Stem Cell) Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B*, Gao Y*, Gao S*. (2022) N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during maternal-to-zygotic transition. Nature Cell Biology 24(6):917-927. Le R*, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, Li Z, Guo M, Kou X, Zhao Y, Chen M, Zhu Q, Zhao A, Yin J, Sun J, Su Z, Shi K, Gao Y, Chen J, Liu W, Kang L, Wang Y, Li C, Liu X, Gao R, Wang H, Ju Z*, Gao S*. (2021) Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells. Cell Stem Cell 28(4):732-747. Wang C, Liu X, Gao Y, Yang L, Li C, Liu W, Chen C, Kou X, Zhao Y, Chen J, Wang Y, Le R, Wang H, Duan T, Zhang Y*, Gao S*. (2018) Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nature Cell Biology 20(5):620-631. Gao R, Wang C, Gao Y, Xiu W, Chen J, Kou X, Zhao Y, Liao Y, Bai D, Qiao Z, Yang L, Wang M, Zang R, Liu X, Jia Y, Li Y, Zhang Y, Yin J, Wang H, Wan X, Liu W*, Zhang Y*, Gao S*. (2018) Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos. Cell Stem Cell 23(3):426-435. Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z*, Gao S*. (2014) Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell Stem Cell 14(1):27-39. Yang H, Bai D, Li Y, Yu Z, Wang C, Sheng Y, Liu W*, Gao S*, Zhang Y*. (2022) Allele-specific H3K9me3 and DNA methylation marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryos. Nature Cell Biology 24(5):783-792. Yang F, Huang X, Zang R, Chen J, Fidalgo M, Sanchez-Priego C, Yang J, Caichen A, Ma F, Macfarlan T, Wang H, Gao S*, Zhou H, Wang J*. (2020) DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell Stem Cell 26(2):234-250. Yang G, Zhang L, Liu W, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S*, Chen J*, Jiang C*. (2021) Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell 28(1):150-163. Wang C, Chen C, Liu X, Li C, Wu Q, Chen X, Yang L, Kou X, Zhao Y, Wang H, Gao Y*, Zhang Y*, Gao S*. (2022) Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation. Cell Research 32(9):801-813. (Cover Story) Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C*, Gao S*. (2018) Accurate annotation of accessible chromatin in mouse and human primordial germ cells. Cell Research 28(11):1077-1089. Liu W, Liu X, Wang C, Gao Y, Gao R, Kou X, Zhao Y, Li J, Wu Y, Xiu W, Wang S, Yin J, Liu W, Cai T, Wang H, Zhang Y*, Gao S*. (2016) Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing. Cell Discovery 2:16010. Chen C, Liu W, Guo J, Liu Y, Liu X, Liu J, Dou X, Le R, Huang Y, Li C, Yang L, Kou X, Zhao Y, Wu Y, Chen J, Wang H, Shen B*, Gao Y*, Gao S*. (2021) Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein Cell 12(6):455-474. (Cover Story) Liu K, Xu X, Bai D, Li Y, Zhang Y, Jia Y, Guo M, Han X, Liu Y, Sheng Y, Kou X, Zhao Y, Yin J, Liu S, Chen J, Wang H, Wang Y, Liu W*, Gao S*. (2023) Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm. Protein Cell 14(4):262-278. (Cover Story) Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X*, Jiang C*, Gao S*. (2020) Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos. Nature Communications 11(1):1813.

学术兼职

中国细胞生物学学会 副理事长 中国动物学会细胞及分子显微技术学分会 主任委员 中国细胞生物学学会染色质生物学分会 会长 学术期刊Cell Stem Cell 顾问委员会委员 学术期刊Journal of Biological Chemistry 编委会委员 学术期刊Biology of Reproduction 编委会委员 学术期刊Journal of Reproduction and Development 编委会委员 学术期刊Cellular Reprogramming 编委会委员 学术期刊Cell Regeneration 副主编 学术期刊Journal of Animal Science and Biotechnology 副主编 学术期刊Science of China Life Science (中国科学-生命科学) 编委会委员 学术期刊《遗传》 编委会委员

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