个人简介

2000年，清华大学生物科学与技术系，本科毕业。2005年，清华大学生物科学与技术系细胞与发育专业，博士毕业。博士期间，主要研究FGF信号通路在 斑马鱼早期胚胎发育中的作用。2005年至2010年，耶鲁大学医学院遗传系从事博士后研究，主要研究多囊肾的分子机制。2010年9月起，任同济大学生 命科学与技术学院教授，博导。

研究领域

纤毛相关新因子的鉴定和功能研究 肾脏发育与肾脏疾病的机制研究 其他人类罕见病/纤毛类疾病的机制研究 肾脏干细胞的研究

遗传与发育

近期论文

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Ruikun Hu, Weilai Huang, Miaomiao Jin, Jiangfang Liu, Yue Wu, Jingyu Li, Zehao Yu, Hong Wang, and Ying Cao. Mutagenesis of ciliary candidate genes with CRISPR/Cas9 system in zebrafish identifies genes required for retina development. FASEB J. 2019 Wenyan Xu, Miaomiao Jin, Weilai Huang, Ruikun Hu, Hong Wang, Jingyu Li and Ying Cao. Apical PtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidney disease. FASEB J. 2019 R. Sun, Y. Wang, M. Jin, L. Chen1, Y. Cao*, and F. Chen*. Identification and Functional Studies of MYO1H for Mandibular Prognathism. Journal of Dental Research, 2018: 1–9 (*共通讯) Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun. 2018 Jun 13;9(1):2302. Xu D, Lv J, He L, Fu L, Hu R, Cao Y*, Mei C*. Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB J. 2018 Mar. (*共通讯) Yunru Chen, Shiyang Zeng, Ruikun Hu, Weilai Huang, Xiangxiu Wang, Jiangfang Liu, Luying Wang, Guifen Liu, Ying Cao* and Yong Zhang*. Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish. PLoS One，2017 Aug 11，12(8):e0182528. (*共通讯) Wenyan Xu, Miaomiao Jin, Ruikun Hu, Hong Wang, Fan Zhang, Shiaulou Yuan and Ying Cao. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology, 2017 Jan;28(1):118-129. (highlighted in Nature Reviews Nephrology, 2016, 12: 508) Cao, Y., Park, A. and Sun, Z. (2010). Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity. J Am Soc Nephrol. 21(8):1326-33. (cover story) Cao, Y., Semanchik N., Lee SH., Somlo S., Barbano PE., Coifman R., Sun Z. (2009). Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. PNAS, 106(51):21819-21824 Rui, Y.*, Xu, Z.*, Xiong, B.*, Cao, Y.*, Lin, S., Zhang, M., Chan, SC., Luo, W., Han, Y., Lu, Z., Ye, Z., Zhou, HM., Han, J., Meng, A., and Lin, SC. (2007). A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell, 13(2):268-82. (*authors contribute equally) Cao, Y., Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A. (2004). fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev Biol, 271:130-143.