郑加麟 - 同济大学

个人简介

郑加麟，医学博士，特聘教授，博士生导师，国家重大科学研究计划项目（973）首席科学家。现任同济大学医学院院长，曾任同济大学医学与生命科学部主任，美国内布拉斯加州大学医学中心学术协理副校长，研究生院副院长。在科研学术方面，长期致力于巨噬细胞和神经小胶质细胞在中枢神经退行性疾病中的作用及其机制研究，并着重探索诱导性多能干细胞及诱导性神经干细胞对这些退行性疾病的潜在应用价值。主要研究方向包括：(1) 神经干细胞再编程及神经退行性疾病的干细胞治疗{阿尔茨海默病(AD)和帕金森病(PD)}；(2) 谷氨酰胺䩈调控外泌体释放机制及干细胞与神经细胞网络及环路的调控；(3)神经退行性疾病{阿尔茨海默病(AD)和帕金森病(PD)}中神经环路的免疫调控及功能研究。十余年获得美国国立卫生研究院(NIH) 二个R01和一个P01 (Program Project) 项目的连续资助，所在实验室年资助金额100万美元。已在许多国际学科专业杂志上发表140余篇研究论著，包括Neuron、Stem Cells、Journal of Neuroscience、Journal of Immunology等国际期刊，论文被引用次数5647次，H-index指数44，i10指数91。作为首席科学家主持“干细胞研究”国家重大科学研究计划1项，承担国家自然科学基金项目重点项目1项、海外及港澳学者合作研究基金1项。获中国发明专利授权2项、申请国际PCT专利1项。2005年荣获内布拉斯加大学Gilmore杰出青年科学家奖，2008年荣获美国内布拉斯加州长Dave Heineman“Marshall” 奖及内布拉斯加大学杰出科学家奖，2019年荣获同济大学教育发展基金优秀工作者。担任Transl Neurodegen（2018年IF:5.872）、 Curr Mol Med杂志副主编、美国国立卫生研究院 (NIH) “神经内分泌及神经免疫”和 “干细胞及细胞命运”专家组成员、中国国家自然科学基金委员会生命科学部及医学部重点项目 “神经及心理学科评审专家组”特邀终审专家、医学中心国际联盟(AAHCI)指导委员会成员、教育部教指委委员、教育部临床医学专业认证专家、上海市医学会医学教育专科分会第七届委员会副主任委员、中国康复医学会康复教育高校工作委员、中国教育国际交流协会国际医学教育分会第一届理事会理事、中国医学模拟教学联盟成员、中国整形美容协会干细胞研究与应用分会理事。同时担任国际知名学会委员(美国神经科学协会，美国微生物协会，国际神经化学协会，国际神经病毒协会，美国免疫协会，国际神经毒性协会，国际神经免疫药理学协会、国际神经免疫协会等)。

研究领域

神经干细胞再编程及神经退行性疾病的干细胞治疗{阿尔茨海默病(AD)和帕金森病(PD)} 谷氨酰胺䩈调控外泌体释放机制及干细胞与神经细胞网络及环路的调控神经退行性疾病{阿尔茨海默病(AD)和帕金森病(PD)}中神经环路的免疫调控及功能研究

近期论文

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Xia X#*, Wang Y#, Zheng JC*. Internal m7G methylation: a novel epitranscriptomic contributor in brain development and diseases. Mol Ther-Nucl Acids. 2023 Jan 11;31:295-308. doi: 10.1016/j.omtn.2023.01.003. Li X, Zhu Y, Wang Y*, Xia X*, Zheng JC*. Neural stem/progenitor cell-derived extracellular vesicles: a novel therapy for neurological diseases and beyond. Medcomm. 2023 Feb 7;4(1):e214. doi: 10.1002/mco2.214. Liang Q, Yang H, Zhang Z, Zheng JC*, and Qin, Z*.Loss of mammalian glutaminase orthologs impairs sperm function in caenorhabditis elegans. iScience. 2023 Feb 15;26(3):106206. doi: 10.1016/j.isci.2023.106206. Gao G#, Li C#, Ma Y#, Liang Z#, Li Y, Li X, Fu S, Wang Y*, Xia X*, Zheng JC*. Neural stem cell-derived extracellular vesicles mitigate Alzheimer's disease-like phenotypes in a preclinical mouse model. Signal Transduct Target Ther. 2023; Accepted. Yuan P#, Bi Y#, Luo Y#, Tao Q, Gong S, Wang Y, Xiong L*, Xia X*, Zheng JC*. Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China. Transl Neurodegener. 2023; Accepted. Fu S#, Li C#, Yang W, Chen H, Wang Y, Zhu Y, Zhu J, Zhang B*, Xia X*, Zheng JC*. Insulin-incubated palladium clusters alleviate Alzheimer's disease-like phenotypes in a preclinical mouse model. Medcomm. 2023; Accepted. Ji C#, Tang Y#, Zhang Y, Huang X, Li C, Yang Y, Wu Q, Xia X, Cai Q, Qi X*, Zheng JC*.Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors. Cell Reports.2023; Accepted. Xia X#*, Wang Y, Zheng JC#*. Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative disease. Transl Neurodegener. 2022 Dec 12;11(1):53. doi: 10.1186/s40035-022-00330-0. Li Y# , Xia X#*, Wang Y, Zheng JC*. Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease. J Neuroinflammation. 2022 Oct 6;19(1):248. doi: 10.1186/s12974-022-02613-9. Wang Y#, Yuan P#, Ding L#,Zhu J, Qi X, Zhang Y, Li Y, Xia X, Zheng JC*. Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer's disease. Front Cell Neurosci. 2022 Oct 20;16:955511. doi: 10.3389/fncel.2022.955511. Yuan P#, Li J#, Liu J, Liu H, Gong S, Wang L, Liu J, Li C, Wang Y, Xia X*, Zheng JC*. Cognitive dysfunction in patients with pulmonary hypertension. Am J Resp Crit Care. 2022 Nov 15;206(10):1289-1293. doi: 10.1164/rccm.202204-0726LE. Xia X, Wang Y, Qin Y, Zhao S, Zheng JC*. Exosome: a novel neurotransmission modulator or non-canonical neurotransmitter? Ageing Research Reviews. 2022 Feb;74:101558. doi: 10.1016/j.arr.2021.101558. Fu S#, Chen H#, Yang W, Xia X*, Zhao S, Xu, X, Ai P, Cai Q, Li X, Wang Y, Zhu J, Zhang B*, Zheng JC*. ROS-targeted Depression Therapy via BSA-incubated Ceria Nanocluster. Nano Letters. 2022 Jun 8;22(11):4519-4527. doi: 10.1021/acs.nanolett.2c01334. Fu S#, Chen H# Zhao S#, Yang W, Xia X*, Xu, X, Liang Z, Feng X, Wang Z, Ai P, Ding L, Cai Q, Wang Y, Zhang Y, Zhu J, Zhang B*, Zheng JC*. Insulin-incubated palladium clusters promote recovery after brain injury. J Nanobiotechnology. 2022 Jun 25;20(1):299. doi: 10.1186/s12951-022-01495-6. Ding L, Wu H, Wang Y, Li Y, Xia X*, Zheng JC*. m6A reader Igf2bp1 regulates the inflammatory responses of microglia by stabilizing Gbp11 and Cp mRNAs. Front. Immunol.2022 Apr 29;13:872252. doi: 10.3389/fimmu.2022.872252. Gao G#, Li C#, Zhu J#, Sheng S, Liang Z, Fu S, Li X, Sun Y, Wang Y, Feng X, Xia X*, Zheng JC*. Induced neural stem/progenitor cell-derived extracellular vesicles promote recovery post stroke. Clinical and Translational Medicine .2022 Jun;12(6):e936. doi: 10.1002/ctm2.936. Sun Y#, Xia X#, Basnet D, Zheng JC*, Huang J*, Liu J*. Mechanisms of ferroptosis and emerging links to the pathology of neurodegenerative diseases. Front Aging Neurosci. 2022 Jun28;14:904152. doi:10.3389/fnagi.2022.904152. Liu J#, Feng X#, Wang Y, Xia X*, Zheng JC*. Astrocytes: GABAceptive and GABAergic cells in the brain. Front Cell Neurosci. 2022 Jun 10;16:892497. doi: 10.3389/fncel.2022.892497. . Ding L#, Yang X#, Xia X*,Li Y, Wang Y, Li C, Sun Y,Gao G, Zhao S, Sheng S,Liu J , Zheng JC*. Exosomes mediate APP dysregulation via APP-miR-185-5p axis. Frontiers in Cell and Developmental Biology. 2022 Feb 11;10:793388. doi: 10.3389/fcell.2022.793388. Pan J#, Sheng S#, Ye L#, Xu X, Ma Y, Feng X, Qiu L, Fan Z, Wang Y*, Xia X*, Zheng JC*. Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway. Cell Communication & Signaling. 2022; 20(1):7. doi: 10.1186/s12964-021-00760-9. Ji C#, Tang Y#, Zhang Y, Li C, Liang H, Ding L, Xia X, Xiong L, Qi X*, Zheng JC*. Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression. Brain Behavior and Immunity. 2021 Oct 19;99:231-245. doi: 10.1016/j.bbi.2021.10.009. Liu J #, Ai P #, Sun Y #, Yang X, Li C, Liu Y, Xia X *, Zheng JC*.Propofol inhibits microglial activation via miR-106b/Pi3k/Akt axis. Frontiers in Cellular Neuroscience. 2021 Oct 28;15:768364. doi: 10.3389/fncel.2021.768364. eCollection 2021. Ma Y #, Xu X# , Li C, Wang Y, Zhu J , Xia X *, Zheng JC *.Induced neural progenitor cell-derived extracellular vesicles promote neural progenitor cell survival via extracellular signal-regulated kinase pathway. CNS Neuroscience & Therapeutics. 2021 Oct 13. doi: 10.1111/cns.13744. Zhao S#, Sheng S#, Wang Y, Ding L, Xu X, Xia X*, Zheng JC*. Astrocyte-derived extracellular vesicles: a double-edged sword in central nervous system disorders. Neuroscience & Biobehavioral Reviews. 2021 Jun;125:148-159. doi: 10.1016/j.neubiorev.2021.02.027. Sun X, Zhao X, Zhang H, Li J, Jiang C, Chen Y, Zheng JC*. Medical school affiliation accelerates the development of community health centers in China. Annals of Family Medicine, 2021 March, 19 (2) 178. doi:10.1370/afm.2657. Xia X*,Yuan P, Liu Y, Wang Y, Cao W , Zheng JC *. Emerging roles of extracellular vesicles in COVID-19, a double-edged sword? Immunology, 2021 Aug;163(4):416-430. doi: 10.1111/imm.13329. Xia X*, Wang Y, Zheng JC *.COVID-19 and Alzheimer's disease: how one crisis worsens the other. Translational Neurodegeneration. 2021 Apr 30;10(1):15. doi: 10.1186/s40035-021-00237-2. Yuan P, Ding L,Chen H, Wang Y, Li C, Zhao S, Yang X, Ma Y, Zhu J, Qi X, Zhang Y, Xia X*, Zheng JC *. Neural stem cell-derived exosomes regulate neural stem cell differentiation through miR-9-Hes1 axis. Frontiers in Cell and Developmental Biology. 2021 May 13;9:601600. doi: 10.3389/fcell.2021.601600. eCollection 2021. Xia X*, Wang Y, Zheng JC*. Emerging roles of extracellular vesicles in mediating RNA virus infection. Fundamental Research. 2021; 2(1):179-185. doi: 10.1016/j.fmre.2021.02.005. Ding L#, Xu X#, Li C#, Wang Y *, Xia X*, Zheng JC*. Glutaminase in microglia: a novel regulator of neuroinflammation. Brain Behavior and Immunity, 2021 Feb;92:139-156. doi: 10.1016/j.bbi.2020.11.038. Zhang Y, Lu P, Liang F, Ning L, Dong Y, Zheng JC*, Xie Z*.Cyclophilin D contributes to anesthesia neurotoxicity in the developing brain. Front Cell Dev Biol. 2020 Feb 11;7:396. doi: 10.3389/fcell.2019.00396. Gao G#, Li C#, Zhu J#,Wang Y, Huang Y, Zhao S, Sheng S, Song Y, Ji C, Li C, Yang X,Ye L,Qi X,Zhang Y, Xia X*, Zheng JC*. Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release. Front Immunol. 2020 11: 161. doi: 10.3389/fimmu.2020.00161. Xia X#, Li C#, Wang Y, Deng X, Ma Y, Ding L, Zheng JC*. Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell deathresistance than reprogrammed fibroblasts. Transl Neurodegener. 2020 9: 6. doi: 10.1186/s40035-020-0184-6. Qiu L#, Zhang M #, Zhang S, Tang Y, Zhang Y, Li C, Wang Y, Jiang L*, Zheng JC *. Activation of CXCR7 promotes endothelial repair and reduces the carotid atherosclerotic lesions through inhibition of pyroptosis signaling pathways. Aging cell. 2020 January15. doi: 10.1111/acel.13205. Fu S, Wang Y, Xia X *, Zheng JC *. Exosome engineering: current progress in cargo loadingand targeted delivery. NanoImpact. 2020 October 10 . Xia X#*, Wang Y#, Zheng JC*. The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders. Stem Cell Reviews and Reports. 2020 October 8. doi: 10.1007/s12015-020-10050-5. Yuan P, Ai P, Liu Y, Ai Z, Wang Y, Cao W, Xia X*, Zheng JC*. Safety, Tolerability, and Immunogenicity of COVID-19 Vaccines: A Systematic Review and Meta-Analysis. medRxiv. 2020 Nov 4;2020.11.03.20224998. doi: 10.1101/2020.11.03.20224998. Ma Y#, Li C#,Huang Y,Wang Y, Xia X*, Zheng JC*. Exosomes released from neural progenitorcells and induced neural progenitor cellsregulate neurogenesis through miR-21a. Cell Communication and Signaling. 2019 Aug 16;17(1):96.doi: 10.1186/s12964-019-0418-3 4.344. Xia X, Lu H, Li C, Huang Y, Wang Y, Yang X, Zheng JC*. miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis. Stem Cell Res Ther. 2019 Sep 23;10(1):282.doi: 10.1186/s13287-019-1387-6. Xia X, Wang Y, Huang Y, Zhang H, Lu H, Zheng JC*. Exosomal MiRNAs in Central Nervous System Diseases: Biomarkers, Pathological Mediators, Protective Factors and Therapeutic Agents. Progress in Neurobiology. 2019 Sep 19:101694. doi: 10.1016/j.pneurobio.2019.101694. Gao G#, Zhao S#, Xia X#, Li C, Li C, Ji C, Sheng S, Tang Y, Zhu J, Wang Y*, Huang Y*, Zheng JC*. Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease. Front Cell Neurosci. 2019 Jun 28;13:264. doi: 10.3389/fncel.2019.00264. Wang Y, Yin J, Wang G, Li P, Bi G, Li S, Xia X, Song J, Pei G*, Zheng JC*. Responsibility and sustainability in brain science, technology, and neuroethics in China -a culture-oriented perspective. Neuron. 2019 Feb 6;101(3):375-379.doi: 10.1016/j.neuron.2019.01.023 Ma Y#, Wang K#, Pan J, Fan Z, Tian C, Deng X, Ma K, Xia X*, Huang Y*, Zheng JC*. Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways.Neurobiology of Disease, 2019 Apr;124:322-334.doi: 10.1016/j.nbd.2018.12.003. He M, Zhang H, Li Y, Tian C, Tang B, Huang Y*, Zheng J*. Direct and selective lineage conversion of human fibroblasts to dopaminergic precursors. Neurosci Lett. 2019 Apr 23;699:16-23. doi: 10.1016/j.neulet.2019.01.033. Liu J, Li Y, Xia X, Yang X, Zhao R, Peer J, Wang H, Tong Z, Gao F, Lin H, Wu B, Huang Y*, Zheng JC*. Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release. J Neuroimmunol. 2019 Aug 15;333:476962. doi: 10.1016/j.jneuroim.2019.05.003. Zhao R, Li Y, Gorantla S, Poluektova LY, Lin H, Gao F, Wang H, Zhao J, Zheng JC*, Huang Y*. Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL. Antiviral Res. 2019 Aug;168:134-145. doi: 10.1016/j.antiviral.2019.05.015. Ma K #, Deng X #, Xia X#, Fan Z, Qi X, Wang Y, Li Y, Ma Y, Chen Q, Peng H,Ding J, Li C, Huang Y*, Tian C*, Zheng JC*. Direct conversion of mouse astrocytes intoneural progenitor cells and specificlineages of neurons. Transl Neurodegener. 2018 Nov 5;7:29. doi: 10.1186/s40035-018-0132-x 8.014. Huang Y#*, Li Y#, Zhang H#, Zhao R, Jing R, Xu Y, He M, Peer J, Kim YC, Luo J, Tong Z, Zheng JC*. Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869. Cell discovery. 2018 Apr 24;4:19. doi: 10.1038/s41421-018-0017-2. Wu B, Liu J, Zhao R, Li Y, Peer J, Braun AL, Zhao L, Wang Y, Tong Z, Huang Y*, Zheng JC*. Glutaminase 1 Regulates the Release of Extracellular Vesicles during Neuroinflammation through Key Metabolic Intermediate Alpha-Ketoglutarate. Journal of Neuroinflammation. 2018 Mar15(1):79. Doi: 10.1186/s12974-018-1120-x. He M, Zhang H, Li Y, Wang G, Tang B, Zhao J, Huang Y*, Zheng JC*. Cathelicidin-derived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway. Frontiers in Immunology. 2018 Apr 12;9:722.