郝柯 - 同济大学 - 环境科学与工程学院

个人简介

2019 - 同济大学, 环境科学与工程学院, 兼职教授, 教授 2003 - 2005 美国哈佛大学, 生物统计系, 博士后 1998 - 2003 美国哈佛大学, 环境健康系, 博士 1993 - 1997 清华大学, 生物科学与技术系, 学士

研究领域

大气污染与环境健康：利用人群队列和动物模型阐明污染物暴露导致健康损伤的效应和机理。主要疾病领域包括：呼吸疾病，心血管疾病，神经退行性疾病，生殖健康等人类疾病的遗传与环境风险，以及其交互作用高通量生物组学(例如转录组，微生物组)研究，解析污染物暴露导致疾病风险的生物通路环境流行病学&生物组学领域的统计算法开发与应用

近期论文

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Bayesian method to predict individual SNP genotypes from gene expression data. Nature Genetics. 2012. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nature Communications. 2015. Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth. Nature Communications. 2017 EnsembleCNV: an ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data. Nucleic Acids Research. 2019 GIGSEA: Genotype Imputed Gene Set Enrichment Analysis using GWAS Summary Level Data, Bioinformatics, 2019 Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International. 2020 Chronic Exposure to PM2.5 Nitrate, Sulfate, and Ammonium Causes Respiratory System Impairments in Mice, Environmental Science & Technology. 2021 Integrative Prioritization of Causal Genes for Coronary Artery Disease. Circulation: Genome and Precision Medicine. 2022 Ambient Air Pollutants and Traffic Factors Were Associated with Blood and Urine Biomarkers and Asthma Risk. Environmental Science & Technology. 2022 Ethnic disparities in ambient air and traffic-related pollution exposure and ethnic-specific impacts on clinical biomarker levels. Science of The Total Environment. 2023