个人简介
承担国家重大科研仪器研制项目1项，国家自然科学基金面上项目3项，中国博士后科学基金1项，黑龙江省自然科学基金面上项目1项，黑龙江省博士后科研启动金1项和哈工大科研创新基金1项。发表SCI学术论文30余篇，他引800余次，总IF﹥180。研究成果分别获得黑龙江省中医药科学技术奖一等奖和黑龙江省科学技术奖二等奖。
研究领域
光（声）动力治疗技术、生物信息技术在生物医学领域的理、工、医多学科交叉与转化工作
近期论文
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The effect of excitation power density on the Stern-Volmer constant measurement 作者 Kou Meng; Qin Feng; Wang YongDa; Zhang Xiyu; Li Lu; Hu Zheng; Zhao Hua; Zhang Zhiguo 2023 期刊名称 Optics Letters 期卷 48(19):5133-5136
Antitumor Effects of Pegylated Zinc Protoporphyrin-Mediated Sonodynamic Therapy in Ovarian Cancer 作者 Li Jia; Hu Zheng; Zhu Jiwei; Lin Xin; Gao Xu; Lv Guixiang 2023 期刊名称 Pharmaceutics 期卷 15(9):2275
Accurate Determination of the Photosensitizer Stern-Volmer Constant by the Oxygen-Dependent Consumption of 1,3-Diphenylisobenzofuran 作者 Kou Meng; Qin Feng; Wang Yongda; Zhang Xiyu; Hu Zheng; Zhao Hua; Zhang Zhiguo 2023 期刊名称 Journal of Physical Chemistry Letters 期卷 14(32):7193-7197
A New Insight into the Singlet Oxygen Mechanism for Photodynamic Therapy 作者 Kou Meng; Qin Feng; Lv Weiming; Hu Zheng; Zhang Zhiguo 2023 期刊名称 Journal of Physical Chemistry Letters 期卷 14:5613-5617
Highly sensitive measurement method for photosensitizers based on dual-excitation laser modulation technique 作者 Wang Yongda; Hu Zheng; Li Jia; Zhao Yunhan; Kou Meng; Qin Feng; Zhang Zhiguo 2023 期刊名称 Sensors and Actuators B: Chemical 期卷 388:133855
Insight into the Heavy Atom Effect Induced by Environmental Heavy Atoms for Gadolinium-Labeled Hematoporphyrin Monomethyl Ether 作者 Kou Meng; Qin Feng; Wang Yongda; Zhang Xiyu; Hu Zheng; Zhang Zhiguo 2023 期刊名称 Journal of Physical Chemistry B 期卷 127(3):777-782
Precision Killing of Sinoporphyrin Sodium-Mediated Photodynamic Therapy against Malignant Tumor Cells 作者 Lv Guixiang; Dong Zhihui; Zhao Yunhan; Ma Ning; Jiang Xiaochen; Li Jia; Wang Jinyue; Wang Jiaxin; Zhang Wenxiu; Lin Xin; Hu Zheng 2022 期刊名称 International Journal of Molecular Sciences 期卷 23(18):10561
Sinoporphyrin sodium mediated sonodynamic therapy generates superoxide anion under hypoxia environment 作者 Li Enze; Sun Yi; Lv Guixiang; Qin Feng; Zhang Xiyu; Zhang Zhiguo; Zhang Rui; Hu Zheng; Cao Wenwu 2021 期刊名称 New Journal of Chemistry 期卷 45:18994-19001
The abnormal physicochemical phenomena of singlet oxygen sensor green in water in the presence of ultrasound 作者 Li Enze; Sun Yi; Lv Guixiang; Qin Feng; Zhang Xiyu; Zhang Zhiguo; Zhang Rui; Hu Zheng; Cao Wenwu 2021 期刊名称 ChemistrySelect 期卷 6(26):6631-6635
Involvement of hydrogen peroxide in sonodynamical effect with sinoporphyrin sodium in hypoxic situation 作者 Li Enze; Sun Yi; Lv Guixiang; Qin Feng; Zhang Xiyu; Zhang Zhiguo; Zhang Rui; Hu Zheng; Cao Wenwu 2021 期刊名称 Free Radical Research 期卷 55(9-10):958-969
Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model 作者 Wang Shan; Yu Xiaorong; Li Fang; Fan Haixia; Zhao Eryang; Hu Zheng 2021 期刊名称 Cancer Biomark 期卷 31(4):339-350
5-aminolevulinic-acid-mediated Sonodynamic Therapy Improves the Prognosis of Melanoma by Inhibiting Survivin Expression 作者 Fan Haixia; Hu Zheng; Wang Shan; Wu Wen; Liu Xue; Geng Haixia 2020 期刊名称 Cancer Biomark 期卷 28(3):301-308
Hematoporphyrin monomethyl ether mediated sonodynamic antimicrobial chemotherapy on porphyromonas gingivalis in vitro 作者 Zhang Yi; Zhang Hongbo; Zhuang Deshu; Bi Liangjia; Hu Zheng; Cao Wenwu 2020 期刊名称 Microbial Pathogenesis 期卷 144:104192
Hematoporphyrin monomethyl ether-mediated sonodynamic therapy induces A-253 cell apoptosis 作者 Zhang Yi; Bi Liangjia; Hu Zheng; Cao Wenwu; Zhuang Deshu 2020 期刊名称 Oncology Letter 期卷 19(4):3223-3228
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis 作者 Li Enze; Sun Yi; Lv Guixiang; Li Yongning; Zhang Zhiguo; Hu Zheng; Cao Wenwu 2019 期刊名称 International Journal of Biochemistry & Cell Biology 期卷 113:104-114
Impact of immunodeficiency on lingual carcinogenesis and lymph node metastasis in mice 作者 Wang Shan; Li Fang; Qiang Dongxia; Hu Zheng; Meng Yan; Shi Lei; Zhao Eryang; Niu Yumei 2019 期刊名称 Journal of Oral Pathology & Medicine 期卷 48(9):826-831
Expression of PIWIL2 in oral cancer and leukoplakia: Prognostic implications and insights from tumors 作者 Wang Shan; Li Fang; Fan Haixia; Xu Jiankai; Hu Zheng 2019 期刊名称 Cancer Biomarkers 期卷 26(1):11-20
Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions 作者 Hu Zheng; Tie Yi; Lv Guixiang; Zhu Jie; Fu Hanjiang; Zheng Xiaofei 2018 期刊名称 International Journal of Oncology 期卷 53(4):1691-1702
Effects of low-intensity ultrasound combined with low-dose carboplatin in an orthotopic hamster model of tongue cancer: A preclinical study 作者 Li Haixia; Zheng Jinhua; Ji Liang; Liu Guanyao; Lv Yvkun; Yang Dan; Hu Zheng; Chen He; Zhang Fengmin; Cao Wenwu 2018 期刊名称 Oncology Reports 期卷 39(4):1609-1618
Inhibitory effect of aloe emodin mediated photodynamic therapy on human oral mucosa carcinoma in vitro and in vivo 作者 Liu Yunqing; Meng Peisong; Zhang Hongchao; Liu Xu; Wang Mengxi; Cao Wenwu; Hu Zheng; Zhang Zhiguo 2017 期刊名称 Biomedicine & Pharmacotherapy 期卷 97:697-707
miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma 作者 Lv Guixiang; Wu Mingjuan; Wang Meijie; Jiang Xiaochen; Du Jingli; Zhang Kaili; Li Dongliang; Ma Ning; Peng Yahui; Wang Lujing; Zhou Lingyun; Zhao Weiming; Jiao Yufei; Gao Xu; Hu Zheng 2017 期刊名称 Liver International 期卷 37(9):1354-1364
NaYbF4 nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration photodynamic therapy 作者 Zhang Jiayin; Chen Su; Wang Peng; Jiang Dongjie; Ban Dexiang; Zhong Nanzhe; Jiang Guicheng; Li He; Hu Zheng; Xiao Jianru; Zhang Zhiguo; Cao Wenwu 2017 期刊名称 Nanoscale 期卷 9(8): 2706-2710
Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound 作者 Hu Zheng; Lv Guixiang; Li Yongning; Li Enze; Li Haixia; Zhou Qi; Yang Bin; Cao Wenwu 2016 期刊名称 Journal of Experimental & Clinical Cancer Research 期卷 35(1): 71
Small molecule inhibitor of c-Met (PHA665752) suppresses the growth of ovarian cancer cells and reverses cisplatin resistance 作者 Li Enze; Hu Zheng; Sun Yi; Zhou Qi; Yang Bin; Zhang Zhiguo; Cao Wenwu 2016 期刊名称 Tumor Biology 期卷 37(6): 7843-7852
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis 作者 Hu Zheng; Fan Haixia; Lv Guixiang; Zhou Qi; Yang Bin; Zheng Jinhua; Cao Wenwu 2015 期刊名称 Journal of Dermatological Science 期卷 79(2): 155-162
5-Aminolevulinic Acid-Based Sonodynamic Therapy Induces the Apoptosis of Osteosarcoma in Mice 作者 Li Yongning; Zhou Qi; Hu Zheng; Yang Bin; Li Qingsong; Wang Jianhua; Zheng Jinhua; Cao Wenwu 2015 期刊名称 PLoS One 期卷 10(7): e0132074
Mechanism of rat osteosarcoma cell apoptosis induced by a combination of low-intensity ultrasound and 5-aminolevulinic acid in vitro 作者 Li Yongning; Zhou Qi; Yang Bin; Hu Zheng; Wang Jianhua; Li Qingsong; Cao Wenwu 2015 期刊名称 Genetics and Molecular Research 期卷 14(3): 9604-9613
Effect of cell cycle phase on the sensitivity of SAS cells to sonodynamic therapy using low-intensity ultrasound combined with 5-aminolevulinic acid in vitro 作者 Li Nan; Sun Miao; Wang Yao; Lv Yanhong; Hu Zheng; Cao Wenwu; Zheng Jinhua; Jiao Xiaohui 2015 期刊名称 Molecular Medicine Reports 期卷 12(2): 3177-3183
MicroRNA-451 regulates activating transcription factor 2 expression and inhibits liver cancer cell migration 作者 Lv Guixiang; Hu Zheng; Tie Yi; Du Jingli; Fu Hanjiang; Gao Xu; Zheng Xiaofei 2014 期刊名称 Oncology Reports 期卷 32(3): 1021-1028
5-Aminolevulinic acid-mediated sonodynamic therapy reverses macrophage and dendritic cell passivity in murine melanoma xenografts 作者 Wang Shan; Hu Zheng; Wang Xiaolong; Gu Chuanwen; Gao Zhongxiuzi; Cao Wenwu; Zheng Jinhua 2014 期刊名称 Ultrasound in Medicine and Biology 期卷 40(9): 2125-2133
Correlation of microRNAs responding to high dose γ-irradiation with predicted target mRNAs in HeLa cells using microarray analyses 作者 Hu Zheng; Tie Yi; Lv Guixiang; Fu Hanjiang; Xing Ruiyun; Zhu Jie; Sun Zhixian; Zheng Xiaofei 2013 期刊名称 Science Bulletin 期卷 58(36): 4622-4629
MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells 作者 Wei Wei; Hu Zheng; Fu Hanjiang; Tie Yi; Zhang Haihong; Wu Yongge; Zheng Xiaofei 2012 期刊名称 Oncology Reports 期卷 28(2): 701-706
Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA 作者 Li Shuai; Zhu Juanjuan; Fu Hanjiang; Wan Jing; Hu Zheng; Liu Shanshan; Li Jie; Tie Yi; Xing Ruiyun; Zhu Jie; Sun Zhixian; Zheng Xiaofei 2012 期刊名称 Nucleic Acids Research 期卷 40(2): 884-891
A novel method for ionizing radiation-induced RNA damage detection by poly(A)-tailing RT-PCR 作者 Tie Yi; Hu Zheng; Lv Guixiang; Fu Hanjiang; Xing Ruiyun; Zhu Jie; Sun Zhixian; Zheng Xiaofei 2011 期刊名称 Science Bulletin 期卷 56(30): 3172-3177
miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells 作者 Li Na; Fu Hanjiang; Tie Yi; Hu Zheng; Kong Wei; Wu Yongge; Zheng Xiaofei 2009 期刊名称 Cancer Letters 期卷 275(1): 44-53
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