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个人简介

教育背景 1989年本科毕业于云南大学化学系;1992年7月在中科院成都有机所获理学硕士学位;1995年在中科院化学研究所获理学博士学位;1995年至1996年,在中科院成都有机化学研究所任助理研究员,副研究员;1996年至2000年,美国佛蒙特大学化学系博士后;2000年至2003年,美国圣地亚哥制药公司Triad Therapeutics Inc.公司任研究科学家;2011年-2014年兼任重庆大学药学院教授;2003年至今,四川大学华西药学院教授。 获奖情况 2004年第四批四川省卫生厅学术技术带头人 2004年四川省杰出青年 2005年四川省青年科技奖 2008年入选教育部高端人材特聘教授 2009年新世纪百千万人才工程国家级人选 2009年享受国务院特殊津贴专家 2009年评为成都市有突出贡献的优秀专家 2009年国家自然科学基金杰出青年基金获得者; 2010年第八批四川省学术和技术带头人 2010年获教育部百篇全国优秀博士学位论文指导教师 2013年获首届中国化学会"维善天然产物合成奖" 2015年获四川省卫生计生领军人才 2017年获教育部自然科学奖一等奖 2017年四川省卫生计生首席专家 2018年获第十二批四川省学术和技术带头人 2018年获第三届中国药学会‒以岭生物医药创新奖 2019年获第二十届吴阶平‒保罗杨森医学药学奖 2020年获国家技术发明奖二等奖

研究领域

目前主要从事具有重要生理活性的天然产物及药物全合成、新药创制和工业生产研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine Wenlong Hou, Hao Lin, Yanru Wu, Chuang Li, Jiajun Chen, Xiao-Yu Liu*,and Yong Qin*, Nature Communications, 2024, 15, 5332 Enantioselective Synthesis of Antifungal Agent Voriconazole via Asymmetric Epoxidation of Tetrasubstituted (Z)-Alkene Jiale Peng, Ran Li, Zhuo Li, Yu Tang, Jin-Song Yang, Fei Xue*, Yong Qin, Eur J Org Chem 2024, e202400400 Online Design, synthesis, and biological evaluation of new bis-benzylisoquinoline-based analogues as potential neuromuscular blocking agents Lin Fu, Yu Gan, Xiaofeng Liu, Chen Chen, Yi Zhao, Yong Qin, Gang Chen, Hao Song*, Bowen Ke*, Bioorg Med Chem Lett 2024, 108, 129793 Chemoproteomics enables identification of coatomer subunit zeta-1 targeted by a small molecule for enterovirus A71 inhibition Xiaoyong Li, Jin Zhang, Yaxin Xiao, Hao Song, Yuexiang Li, Wei Li, Ruiyuan Cao, Song Li, Yong Qin*, Chu Wang*, Wu Zhong*, MedComm, 2024,5, e587 Asymmetric Synthesis of Triazole Antifungal Agents Enabled by an Upgraded Strategy for the Key Epoxide Intermediate Yu Tang, Zhuo Li, Meiqi Zeng, Ran Li, Hao Song*, Dan Zhang, Fei Xue*, and Yong Qin, J Org Chem 2024, 89, 4971-4978 Asymmetric Synthesis of the Functionalized A/E-Ring Fragment of C18-Diterpenoid Alkaloids Fei Lu, Yu Shao, Shulin Yan, Dingyi Yang, Hao Song, Dan Zhang*, Xiao-Yu Liu*, and Yong Qin, J Org Chem 2024, 89, 4, 2807–2811 Enantioselective total syntheses of (–)-mitragynine, (–)-quinine and (+)-quinidine enabled by Ir-catalysed asymmetric hydrogenation of all-carbon tetrasubstituted cycloalkenes Kai Zhang†, Peng Cui†, Miao Miao, Meiqi Zeng, Xu Wang, Minjie Zhang, Qifeng Chen,Hao Song, * Bowen Ke, and Yong Qin*, Org Chem Front , 2024, 11, 1456-1461 Catalytic Asymmetric Total Synthesis of (−)-Garryine via an Enantioselective Heck Reaction Chuang Li,‡ Fei Lu,‡ Yukun Cai, Cheng Zhang, Yu Shao, Yuanyuan Zhang, Xiao-Yu Liu*, and Yong Qin*, J Am Chem Soc 2024, 146, 1, 1081–1088 Asymmetric hydrogenation of all-carbon tetrasubstituted α-acylpyrazole-β-alkyl cycloalkenes Minjie Zhang†, Peng Cui†, Kai Zhang, Zhen Shi, Xu Cheng, Xiang Ji, Hao Song,* Bowen Ke, and Yong Qin*, Org Chem Front , 2023,10, 5070-5075 Industrial total synthesis of natural medicines Xiao-Yu Liu and Yong Qin*, Nat Prod Rep , 2023, 40, 1694-1700 Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides Jinglin An,‡ Xue Zhou,‡ Yifan Zhang, Zhenfei Ye, Qianyou Guo, Hao Song, Zhenlei Song,* Xiao-Yu Liu and Yong Qin* , Org Chem Front , 2023,10, 1897-1902 Total Synthesis of Vilmoraconitine Jiujian Ji, Jiajun Chen, Sixun Qin, Wanye Li, Jun Zhao, Guozhao Li, Hao Song, Xiao-Yu Liu,* and Yong Qin*, J Am Chem Soc 2023, 145, 7, 3903–3908 Asymmetric synthesis of the functionalized A/E bicyclic fragment of the C19-diterpenoid alkaloids Jiajun Chen,Wenlong Hou,Jiujian Ji,Xiao-Yu Liu*,Yong Qin*,SCIENTIA SINICA Chimica,2022, 53(3), 550-557 Iterative Synthesis of Inulin-type Fructooligosaccharides Enabled by Stereoselective β-D-FructofuranosylationLiang-Jing Zou, Xing Yang, Xi-Rui Zhao, Huan He, Dan Zhang, Hao Song,* Fei Xue,* Yong Qin, J Org Chem, 2022, 87, 22, 15273-15288 Asymmetric total synthesis of buprenorphine and dihydroetorphine Yu Tang, Yifan Zhang, Jun Zhao, Fanglin Xue, Huan He, Fei Xue*, Xiao-Yu Liu and Yong Qin*, Tetrahedron Letters, 2022, 104, 154027  Synthesis of 10,10′-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro Yaxin Xiao+, Jingjing Yang+, Liangjing Zou, Pingzhou Wu, Wei Li, Yunzheng Yan, Yuexiang Li, Song Li, Hao Song,* Wu Zhong,* Yong Qin*, Eur J Med Chem, 2022, 238,114436 Total Synthesis of Sarpagine Alkaloid (−)-Normacusine B Jianquan Zhu, Chao Zhang, Luyi Liu, Chaoyun Xue, Yukun Cai, Xiao-Yu Liu, Fei Xue*, Yong Qin*, Org Lett, 2022, 24, 19, 3515–3520 Concise total synthesis of opioids Huan He,† Fanglin Xue,† Zhao Hu, Peng Li, Qian Xiao, Maojie Zhang, Fei Xue, Dan Zhang, Hao Song, Xiao-Yu Liu, Zhibing Zheng, Song Li, Wu Zhong* and Yong Qin*, Org Chem Front, 2022, 9, 2322-2327 Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer Bingqing Zhou,‡ Di Tian,‡ Jinglin An, Yalan Zhou, Rui Yan, Hao Song, Xiao-Yu Liu * and Yong Qin *, Org Chem Front, 2022, 9, 2135-2140 The diterpenoid alkaloids, in The Alkaloids: Chemistry and Biology, Vol. 87 (Ed.: Hans-Joachim Knölker), Elsevier, 2022, pp. 1−360.Xiao-Yu Liu, Bo-Wen Ke, Yong Qin*, Feng-Peng Wang*, in The Alkaloids: Chemistry and Biology, Vol 87 (Ed : Hans-Joachim Knolker), Elsevier, 2022, pp 1-360 Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis Xiao-Yu Liu, Yong Qin* Green Synthesis and Catalysis, 2022, 3(1), 25-39  Enantioselective total synthesis of (+)-vincamine Fanglin Xue, Hengmao Liu, Rui Wang, Dan Zhang, Hao Song*, Xiao-Yu Liu, Yong Qin*, Chinese Chemical Letters 2022, 33, 2044-2046 Bioinspired scalable total synthesis of opioids Xiaohan Zhou,† Wenfei Li,† Ruijie Zhou,† Xiaoqing Wu, Yuan Huang, Wenlong Hou, Chunxin Li, Yifan Zhang, Wei Nie, Yu Wang, Hao Song, Xiao-Yu Liu, Zhibing Zheng, Fei Xie, Song Li, Wu Zhong,* Yong Qin *, CCS Chem, 2021, 3, 1376–1383 Synthetic studies towards arcutinidine: an alternative strategy for construction of the complete carbon framework Xiaoqing Wu,† Wei Nie,† Min Fu, Xiao-Yu Liu, Fei Xue*, and Yong Qin*, Tetrahedron, 2021, 86, 132092 An improved glycal diazidation protocol with copper catalysis Ruidi Cao, Huan He, Chao Zhang, Xiao-Yu Liu* and Yong Qin*, Tetrahedron Letters, 2021, 70, 153010 Stereoselective synthesis of α-D-fructofuranosides using a 4,6-O-siloxane-protected donor Huan He†, Yanmei Wu†, Yao Huang, Xue Li, Rui Wang, Jin-Song Yang, Xiao-Yu Liu* and Yong Qin*, ,Org Chem Front , 2021, 8, 2263–2267 Synthesis of Three-Dimensionally Fascinating Diterpenoid Alkaloids and Related Diterpenes Xiao-Yu Liu, Feng-Peng Wang, and Yong Qin*, Accounts of Chemical Research, 2021, 54, 1, 22-34 Asymmetric Total Synthesis of (+)-21-epi-Eburnamonine Via a Photocatalytic Radical Cascade Reaction Yuan Huang,† Fanglin Xue,† Hengmao Liu, Fei Xue, Xiao-Yu Liu, Hao Song,* and Yong Qin*, Natural Products and Bioprospecting, 2021, 11, 99-103 Practical synthesis of immucillins BCX-1777 and BCX-4430 Minjie Zhang,‡ Fei Xue,‡ Jingdan Ou, Yuan Huang, Fei Lu, Bingqing Zhou, Zhibing Zheng, Xiao-Yu Liu, Wu Zhong* and Yong Qin*,Org Chem Front , 2020, 7, 3675–3680 Total Synthesis of Liangshanone Hong-Xiu Huang, Fen Mi, Chunxin Li, Huan He, Feng-Peng Wang, Xiao-Yu Liu,* and Yong Qin*, Angew Chem Int Ed, 2020, 59, 23609-23614 Improvement of the C-glycosylation Step for the Synthesis of Remdesivir Fei Xue,⊥ Xinbo Zhou,⊥ Ruijie Zhou, Xiaohan Zhou, Dian Xiao, Eric Gu, Xiaowen Guo, Ji Xiang, Ke Wang, Likai Yang, Wu Zhong,* and Yong Qin*,Org Process Res Dev, 2020, 24(9), 1772-1777 A light- and heat-driven glycal diazidation approach to nitrogenous carbohydrate derivatives with antiviral activity Huan He, Ruiyuan Cao, Ruidi Cao, Xiao-Yu Liu, Wei Li, Yanmei Wu, Pingzhou Wu, Jin-Song Yang, Yunzheng Yan, Jingjing Yang, Zhi-Bing Zheng, Wu Zhong*,Yong Qin and et al, Org Biomol Chem , 2020, 18, 6155–6161

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