彭慧 - 哈尔滨工业大学 - 生命科学与技术学院

个人简介

2009-2013年：武汉大学理学学士生物专业 2013-2018年：印第安纳大学布鲁明顿分校哲学博士生物化学专业 2018-2021年：得克萨斯大学西南医学中心博士后癌症生物学方向 2021年-至今：哈尔滨工业大学讲师

近期论文

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Peng, H.; Wang, Y.; Luo, W., Multifaceted role of branched-chain amino acid metabolism in cancer. Oncogene. 2020, 39 (44):6747-6756. Ramadurgum, P.; Woodard, D. R.; Daniel, S.; Peng, H.; Mallipeddi, P. L.; Niederstrasser, H.; Mihelakis, M.; Chau, V. Q.; Douglas, P. M.; Posner, B. A.; Hulleman, J. D., Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chem Biol. 2020, 27 (5), 622-634.e6. Datta, S.; Peng, H.; Hulleman, J. D., Small Molecule-Based Inducible Gene Therapies for Retinal Degeneration. Adv Exp Med Biol. 2019, 1185, 65-69. Peng, H.#; Chau, V. Q.#; Phetsang, W.; Sebastian, R. M.; Stone, M. R. L.; Datta, S.; Renwick, M.; Tamer, Y. T.; Toprak, E.; Koh, A. Y.; Blaskovich, M. A. T.; Hulleman, J. D., Non-Antibiotic Small Molecule Regulation of DHFR-Based Destabilizing Domains in Vivo. Mol Ther Methods Clin Dev. 2019, 15, 29-37. Peng, H.; Hulleman, J. D., Prospective Application of Activity-Based Proteomic Profiling in Vision Research-Potential Unique Insights into Ocular Protease Biology and Pathology. Int. J. Mol. Sci. 2019, 20 (16), 3855. Peng, H.; Zhang, Y.; Trinidad, J. C.; Giedroc, D. P., Thioredoxin Profiling of Multiple Thioredoxin-Like Proteins in Staphylococcus aureus. Front microbiol. 2018, 9, 2385. Shen, J.; Walsh, B. J. C.; Flores-Mireles, A. L.; Peng, H.; Zhang, Y.; Zhang, Y.; Trinidad, J. C.; Hultgren, S. J. and Giedroc, D. P., Hydrogen sulfide sensing through reactive sulfur species (RSS) and nitroxyl (HNO) in Enterococcus faecalis. ACS Chem Biol. 2018, 13 (6), 1610-1620. Peng, H.; Zhang, Y.; Palmer, L. D.; Kehl-Fie, T. E.; Skaar, E. P.; Trinidad, J. C.; Giedroc, D. P., Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus. ACS Infect Dis. 2017, 3 (10), 744-755. Peng, H.; Shen, J.; Edmonds, K. A.; Luebke, J. L.; Hickey, A. K.; Palmer, L. D.; Chang, F.-M. J.; Bruce, K. A.; Kehl-Fie, T. E.; Skaar, E. P.; Giedroc, D. P., Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus. mSphere. 2017, 2 (3). Shen, J.; Peng, H.; Zhang, Y.; Trinidad, J. C.; Giedroc, D. P., Staphylococcus aureus sqr Encodes a Type II Sulfide:Quinone Oxidoreductase and Impacts Reactive Sulfur Speciation in Cells. Biochem. 2016, 55 (47), 6524-6534. Higgins, K. A.; Peng, H.; Luebke, J. L.; Chang, F. M.; Giedroc, D. P., Conformational analysis and chemical reactivity of the multidomain sulfurtransferase, Staphylococcus aureus CstA. Biochem. 2015, 54 (14), 2385-98. Luebke, J. L.; Shen, J.; Bruce, K. E.; Kehl-Fie, T. E.; Peng, H.; Skaar, E. P.; Giedroc, D. P., The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus. Mol. Microbiol. 2014, 94 (6), 1343-60.