个人简介
Vanessa Hearnden joined the Department of Materials Science and Engineering in 2015 as Lecturer in Biomaterials and Tissue Engineering. Vanessa’s undergraduate degree was in Biomedical Science; she then obtained her PhD in Tissue Engineering from the University of Sheffield in 2011. Vanessa previously worked as a post doc in the Medical School and School of Clinical Dentistry where she gained experience of both lab based studies and clinical research.
研究领域
Vanessa’s research focuses on tissue engineering as a tool to both understand the fundamentals of disease processes and to develop novel diagnostic and treatment strategies.
Tissue engineering of soft tissues for the treatment of disease
Vanessa is interested in developing tissue engineered products for the treatment of disease or injury, in particular those affecting the oral mucosa. She has a strong interest in clinical translation and has a network of clinical collaborators.
Trans-mucosal drug delivery
Trans-mucosal drug delivery offers potential as an alternative to parenteral administration. Vanessa is interested in the development of novel drug delivery systems to facilitate effective drug delivery via this route.
Three dimensional in vitro models of oral cancer
Vanessa, along with colleagues in the School of Clinical Dentistry, developed a series of tissue engineered models ranging from healthy oral epithelium to precancerous dysplastic lesions and invasive squamous cell carcinoma. These three dimensional in vitro models provide a valuable tool for studying many aspects of tumour biology including the tumour microenvironment and disease progression.
Novel diagnostic technologies for oral cancers
Quick, non-invasive and accurate diagnosis of suspicious oral lesions is a key priority in oral medicine. Vanessa has worked on a number of projects which focus on developing new technologies to address this need, including a multi-centre international study investigating a novel micro-fluidic device which could produce fast diagnoses of potentially malignant oral lesions.
近期论文
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Boadi J, Fernandes J, Mittar S, Hearnden V, Lu Z, MacNeil S, Thornhill MH, Murdoch C, Hunter KD & Matcher SJ (2015) Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography. Sovremennye tehnologii v medicine, 7(1), 60-68. View this article in WRRO
Murdoch C, D'Apice K, Brown B, Hearnden V, Speight P, Hegarty A, Healey J, Highfield P, Tidy J & Thornhill M (2014) Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions. International Journal of Nanomedicine, 9, 4521-4521. View this article in WRRO
Sorrell I, Shipley RJ, Hearnden V, Colley HE, Thornhill MH, Murdoch C & Webb SD (2014) Combined mathematical modelling and experimentation to predict polymersome uptake by oral cancer cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 10(2), 339-348. View this article in WRRO
Colley HE, Hearnden V, Avila-Olias M, Cecchin D, Canton I, Madsen J, MacNeil S, Warren N, Hu K, McKeating JA, Armes SP, Murdoch C, Thornhill MH & Battaglia G (2014) Polymersome-mediated delivery of combination anticancer therapy to head and neck cancer cells: 2D and 3D in vitro evaluation.. Mol Pharm, 11(4), 1176-1188.
Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Kerr AR, Lockhart PB, Patton LL, Porter S & Thornhill MH (2012) New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Advanced Drug Delivery Reviews, 64(1), 16-28.
Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH & Macneil S (2012) Tissue-engineered oral mucosa.. J Dent Res, 91(7), 642-650.
Colley HE, Hearnden V, Jones AV, Weinreb PH, Violette SM, MacNeil S, Thornhill MH & Murdoch C (2011) Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma. British Journal of Cancer, 105(10), 1582-1592. View this article in WRRO
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