Wharton, Stephen - University of Sheffield - Department of Neuroscience

个人简介

2014 – current: Professor in Neuropathology – University of Sheffield 2011 – 2013: Clinical Reader / honorary consultant in Neuropathology – University of Sheffield 2001 – 2010: Senior lecturer / honorary consultant in Neuropathology – University of Sheffield 1997 - 2001: Senior lecturer / honorary consultant in Neuropathology – Edinburgh University

研究领域

My research interests are in the pathology and pathogenesis of neurodegenerative disorders, particularly the dementias and their relationship to brain ageing.

近期论文

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Ince PG, Minett T, Forster G, Brayne C, Wharton SB. Microinfarcts in an older population-representative brain donor cohort (MRC-CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease. Neuropathol Appl Neurobiol Early online doi10.1111/nan.12363. Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG, Heath PR. Expression microdissection of enriched cell populations from archival brain tissue. J Neurosci Methods 2016: 268:125-130. * Matthews FE, Stephan BCM, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C, Cognitive Function and Ageing Studies (CFAS) Collaboration*. A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nat Commun 2016; 7:11398. [*Member of the Collaborative Group]. Wharton SB, Minett T, Drew DR, Forster G, Matthews F, Brayne C, Ince PG. Epidemiological pathology of tau in the ageing brain. Application of staging for neuropil threads (BrainNet Europe Protocol) to the MRC Cognitive Function and Ageing Brain Study. Acta Neuropathol Commun 2016; 4:11. Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE; MRC Cognitive Function Ageing Neuropathology Study Group. The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neurosci Lett 2015; 609:11-17. doi: 10.1016/j.neulet.2015.10.001 Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villasenor I, Heath PR, Romero IA, Ince PG, Wharton SB. Insulin and IGF-1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain 8:51 DOI 10.1186/s13041-015-0138-6. Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl, J, Wharton SB, den Dunnen W, Rub U. Precortical phase of Alzheimer’s disease (AD)-related tau cytoskeletal pathology. Brain Pathol 2016; 26:371-386.