Simpson, Julie - University of Sheffield - Department of Neuroscience

个人简介

I graduated from the University of Sheffield in 1995 with a BSc (Hons) in Neuroscience, and was awarded a PhD in Neuroimmunology from Sheffield Hallam University in 1999. I joined the Department of Neuroscience at Sheffield University in 2002 and have been a member of the Neuropathology research group since 2004. I was appointed Lecturer in Translational Neuropathology at SITraN in 2016, and continue to work closely with the Neuropathology team.

研究领域

My main research interests are identifying and understanding neuroinflammatory contributions to ageing and dementia, particularly age-associated white matter pathology, using the complementary approaches of human brain analysis and cell models. My research primarily focusses on detailed immunohistological characterisation and gene expression profiling of specific cell populations in the ageing brain, using the brain donor resource of the MRC Cognitive Function and Ageing Study. Investigating glial activation and function is crucial to understanding the inflammatory response in the ageing brain and their association with white matter pathology.

近期论文

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Waller R, Woodroofe MN, Wharton SB, Ince PG, Francese S, Heath PR, Cudzich-Madry A, Rounding N, Sharrack B, Simpson JE. Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. J Neuroimmunol 299:139-146. Garwood CJ, Ratcliffe LE, Simpson JE, Heath PR, Ince PG, Wharton SB. (2016) Astrocytes in Alzheimer’s and other neurodegenerative diseases; a supporting player with a central role. Neuropathology and Applied Neurobiology Appleby-Mallinder C, Wyles MD, Simpson JE, Wharton SB, Ince PG, Heath PR (2016) Expression microdissection isolation of enriched cell populations from archival brain tissue. J Neurosci Methods 268:125-130. Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M, Wharton SB, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. (2016) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology 42(2):167-179. Fluteau A, Ince PG Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB, Simpson JE. (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters 609:11-17.