Shaw, Pamela - University of Sheffield - Department of Neuroscience

个人简介

Professor Shaw graduated in Medicine with 1st Class Honours from the University of Newcastle in 1979. She undertook her MRCP and Specialist Training in Neurology training in Newcastle. In 1988 she was awarded an MD with commendation for her work on the neurological complications of coronary bypass surgery. After an intermediate fellowship award from the Wellcome Trust, she was awarded a Wellcome Senior Fellowship in Clinical Science which she held from 1991 -2000. In 1997 she was appointed Professor of Neurological Medicine at the University of Newcastle and in 2000 was appointed as Professor of Neurology at the University of Sheffield. As an undergraduate in Newcastle she was awarded the Stephen Scott; Gibb; Mary Gordon; Mona McNaughton and Phillipson Prizes/Scholarships. Recent post-graduate awards include: ABN Sir Charles Symonds award (1991;1996;2001); American Academy of Neurology Sheila Essey award 2001; Royal College of Physicians Jean Hunter award 2006 and the International ALS/MND Forbes Norris award 2007.

研究领域

Professor Shaw’s research is focused on 3 main goals: To understand the function of motor neurones in health and disease and to translate basic science findings into health benefits for patients with degenerative motor system disorders. To provide excellent clinical care for patients with motor system disorders, at all disease stages incorporating: multidisciplinary team working, evidence based standards of care for symptomatic management, and evaluation of new neuroprotective therapies. To foster excellent training for clinical and scientific junior staff with the aim of ensuring high standards of future care and linking new developments in medical science firmly to the needs of patients with neurological disorders. Since 1983 she has supervised the research training of 103 individuals from medicine and science including 30 PhD/MD students.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Pattern of spread and prognosis in lower limb onset ALS. MR Turner, A Brockington, J Scaber, H Hollinger, R Marsden, PJ Shaw, K Talbot. Amyotrophic Lateral Sclerosis 11:369-373;2010. Oxidative stress in ALS: key role in motor neuron injury and a therapeutic target. SC Barber, PJ Shaw. Free Rad Biol Med 2010;48:629-641. Broad clinical phenotypes associated with TAR-DNA binding protein (TARD-BP) mutations in amyotrophic lateral sclerosis. J Kirby, EF Goodall, W Smith, R Masanzu, JA Hartley, R Hibberd, HC Nixon, S Wharton, KE Morrison, PG Ince, CJ McDermott, PJ Shaw. Neurogenetics 2010:11:217-225. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. JE Simpson. PG Ince, LJ Haynes, R Theaker, C Gelsthorpe, L Bazter, G Forster, GL Lace, PJ Shaw, FE Matthews, GM Savva, C Brayne, SB Wharton on behalf of the MRC Congitive Function and Ageing Neuropathology Study Group. Neuropathol Appl Neurobiol 36:25-40; 2010. Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis. C Hewitt, J Kirby, JR Highley, JA Hartley, R Hibberd, H Hollinger, TL Williams, PG Ince, CJ McDermott, PJ Shaw. Archives of Neurology 2010;67:1-8. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. JE Simpson, PG Ince, G Lace, G Forster, PJ Shaw, F Matthews, G Savva, C Brayne, SB Wharton. Neurobiol Ageing 2010;31:578-590.