Ning, Ke - University of Sheffield - Department of Neuroscience

个人简介

I graduated in Medicine from First Military Medical University (Southern Medical University) in China in 1985. I undertook my Specialist Training in Neurosurgery at Sun Yatsen University of Medical Science in China and got a M.Sc in Neurosurgery in 1991. I obtained my PhD in neuroscience at the Third Military Medical University in China In 1996 and was promoted to an associate professor in neurosurgery at Southern Medical University in China in 1997. Since 1999, I have undertaken full time research in neuroscience in the USA, Canada and the UK. I joined the University of Sheffield as a Lecturer in Translational neuroscience in 2006 and was promoted to a Senior Lecturer in Translational Neuroscience in 2011. I have been closely involved in translational neuroscience research and teaching in motor neuron diseases.

研究领域

The focus of my research is the use of viral vector-mediated gene therapy and stem cell strategies to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). ALS/MND is a common adult onset neurodegenerative disease characterised by progressive degeneration of motor neurones in the brainstem and spinal cord. There is no effective treatment or cure for MND/ALS and other neurodegenerative disorders. Gene therapy approaches offer a promising strategy for delivery of genes to enhance motor neuron survival. New approaches for the treatment of neurological disorders have been developed by using lentiviruses and other viruses (Adeno-associate virus AAV6, AAV9 and so on). These vectors have been refined to a very high safety and efficiency levels. Lentiviruses are particularly advantageous for use in gene transfer to the nervous system. Numerous animal studies have now been undertaken with these vectors and correction of disease models has been obtained. Recent studies have demonstrated very good efficacy of Lentiviral- or AAV9-mediated gene therapy approaches in ALS, SMA and other degenerative disorders. These studies provide great optimism for the future utility of lentiviral or AAV gene delivery as a therapeutic strategy for neurodegenerative diseases.

近期论文

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Seytanoglu A, Alsomali NI, Valori CF, McGown A, Kim HR, Ning K, Ramesh T, Sharrack B, Wood JD, Azzouz M.(2016) Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience, 322:287-297. Little D, Valori CF, Mutsaers CA, Bennett EJ, Wyles M, Sharrack B, Shaw PJ, Gillingwater TH, Mimoun Azzouz M, Ning K. (20142015) PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy. Molecular Therapy, 23(2):270-7. 2014 Nov 5. doi: 10.1038/mt.2014.209. [Epub ahead of print] Mohammedeid AM, Lukashchuk V, Ning K. (2014) Protein aggregation and Arfaptin2: A novel therapeutic target against neurodegenerative diseases. New Horizons in Translational Medicine, 2: 12–15. (Review) Dong C, Wang X, Wang G, Zhang W, Zhu L, Gao S, Yang D, Qing Y, Cheng Y, Deng H, Ning K, Liang A, Gao Z, Liang Q, Xu J.(2014) A stress-induced cellular aging model with postnatal neural stem cells. Cell Death and Disease 2014 Mar 13; 5: e1116. Yang D, Wang XL, Ismail A, Ashman CJ, Valori CF, Wang G, Gao S, Higginbottom A, Ince PG, Azzouz M, Xu J, Shaw PJ, Ning K (2014). PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons. Cell Death and Disease; 2014 Feb 27; 5: e1096. Gao S, Zhao P, Lin C, Sun Y, Wang Y, Zhou Z, Yang D, Wang X, Xu H, Zhou F, Cao L, Zhou W, Ning K, Chen X, Xu J (2013). Differentiation of Human-Adipose Derived Stem Cells into neuron-like cells which are compatible with photocurable three-dimensional scaffolds. Tissue Eng Part A. 2013 Nov 19. [Epub ahead of print]