Mortiboys, Heather - University of Sheffield

个人简介

I was awarded my PhD from the International Max Planck PhD Program in Dresden Germany in 2006 with the grade summa cum laude; this project focused on the ‘Influence of mitochondrial energy metabolism on cellular function: implications for neurometabolic and neurodegenerative diseases.’ After which I worked in the Neurology department at the University Hospital Dresden as a research associate on an EU funded project investigating Co-enzyme Q deficiency in patient tissue. I joined the Neuroscience department at the University of Sheffield in 2006 to set up mitochondrial investigations in models of Parkinson’s Disease working as a postdoctoral research associate with Prof. Oliver Bandmann. I recently became a Parkinson’s UK Senior Research Fellow based within the Sheffield Institute for Translational Neuroscience (SITraN) to continue and expand this work setting up my own laboratory.

研究领域

My research interests are concerned with investigating mitochondria in neurodegenerative diseases, primarily focused on Parkinson’s Disease. This encompasses mitochondrial function, DNA, morphology and recycling. My research focuses on both trying to further the understanding of the causes of mitochondrial problems in neurodegenerative conditions and in vitro drug screening for molecules which rescue mitochondrial function in patient tissue.

近期论文

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Allen S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ, Shaw PJ (2013) SOD1 mutation leads to altered metabolic pathways for energy generation in Amyotrophic Lateral Sclerosis patient fibroblasts. Free Radical Biology and Medicine, Epub ahead of print. Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Brown L, McTighe A, Soellner R, Allen CE, Heath PR, Milo M, Reichert AS, Köster RW, Ingham PI, Bandmann O (2013) TigarB as a novel disease-modifying target in PINK1 deficiency. Annals of Neurology, 74(6):837-47. Mortiboys H, Aasly J, Bandmann O (2013) Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson’s disease. Brain, 136(Pt 10):3038-50 Mortiboys H, Cox A, Brock IW, Bandmann O (2013) The Parkinson’s Disease mutation LRRK2 G2019S is not increased in breast cancer patients in the absence of Parkinson’s disease. Journal of Neurology, 260(8):2177-8. Mortiboys H, Johansen KK, Aasly JO, Bandmann O (2010). Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2. Neurology.75(22):2017-20.