Mead, Richard - University of Sheffield - Department of Neuroscience

个人简介

2013 - Present: Kenneth Snowman-MND Association Lecturer in Translational Neuroscience 2010- 2013: SITraN Senior Research fellow in Translational Neuroscience, University of Sheffield, UK. 2005-2010: Postdoctoral Research Fellow, University of Sheffield, UK. 2002-2004: Pharmacology Team leader, Celltech/UCB, Cambridge, UK. 2001-2002: Postdoctoral research assistant, Department of Biochemistry, University of Wales College of Medicine, Cardiff, UK. 1998-2001: PhD (Neuroimmunology), University of Wales College of Medicine, Cardiff, UK.

研究领域

Research focused on drug discovery in motor neurone disease and amyotrophic lateral sclerosis (MND/ALS), from target identification, through in vitro screening to in vivo disease model testing. Specific areas include: Pharmacological manipulation of in vitro and in vivo model systems to dissect mechanisms in MND Small molecule drug development for inflammatory and oxidative stress targets Improving screening methodologies, evolving new in vivo screening paradigms with improved welfare, reduced biological variation and faster throughput Target identification and traditional high throughput screening Development and screening of phenotypic assays using high content imaging Identification of ‘translational’ biomarkers, applicable in both preclinical and clinical settings Investigating novel cell therapy paradigms in MND/ALS Assist in the design and execution of therapeutic studies in the spinal muscular atrophy (SMA) preclinical model.

近期论文

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Stephenson J, Alix J, Shaw PJ, Mead RJ . (2016) Phenotypic Characterisation of the Human TDP-43Q331K Transgenic Mouse Model of Amyotrophic Lateral Sclerosis Demonstrates Potential for Evaluation of Therapeutic Agents. Bennett, E, Mead RJ, Azzouz M, Shaw PS and Grierson A. Early detection of motor dysfunction in the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS) using home cage running wheels. PLoS One 2014 9(9): e107918. doi:10.1371/journal.pone.0107918 Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ and Shaw PJ. S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. Free Radic Biol Med 2013. 61C, 438-452. Mead RJ, Bennet E, , Kennerly A, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M, Grierson A, Shaw PJ. Optimisation of pre-clinical pharmacology studies in the SOD1G93A transgenic mouse model of Motor Neuron Disease. 2010. PLoS One 2011. 6(8), e23244. Barber SC, Higginbottom A, Mead RJ, Barber S and Shaw PJ. (2009) An in vitro screening cascade to identify neuroprotective antioxidants in ALS. Free Radical Biology and Medicine 2009. 46(8), 1127-38.