Majid, Arshad - University of Sheffield - Department of Neuroscience

个人简介

Professor Arshad Majid’s professional mission is to develop new therapies for patients afflicted with neurological diseases, especially cerebrovascular diseases. Professor Majid’s training and background is unique in that as well as being a leading translational neuroscientist, he is also an accomplished Vascular and Interventional Neurologist. He graduated in Medicine from the University of Glasgow, Scotland. After obtaining Membership of the Royal College of Physicians (MRCP) he moved to the USA where he did further training in Neurology at the University of Pennsylvania and Fellowship training in Stroke Research at Washington University in St. Louis. He did additional Fellowship training in Endovascular Surgical Neuroradiology at the Medical College of Wisconsin. Professor Majid has published extensively in high impact international peer-reviewed journals, and presented at national and international meetings. After finishing his training, Professor Majid served as the founding Director of the Division of Cerebrovascular Diseases at Michigan State University and was the founding Medical Director of the William and Claire Dart Stroke Center at Sparrow Health System. Professor Majid is a diplomate of the American Board of Psychiatry and Neurology and is a Fellow of the Royal College of Physicians and Surgeons of Glasgow and also serves as their Regional Advisor. He joined the University of Sheffield and Royal Hallamshire Hospital in August 2013 as Professor of Cerebrovascular Neurology and Consultant Neurologist.

研究领域

Professor Majid is the Director of the Comprehensive Cerebrovascular Research Unit (CCRU). Professor Majid's focus is translational neuroscience research with special focus on cerebrovascular disease and neuroinflammation. Stroke models: The models that are used in his research include both in vitro models (cell culture) and in vivo models (focal ischaemia and global ischaemia). He is interested in understanding the pathogenesis of cerebrovascular diseases with the overall aim of developing new treatment and brain repair strategies. To this end, his lab has been successful in developing two novel treatments which are undergoing further preclinical testing before they are taken to the clinic. He has a particular interest in ischaemic preconditioning, a fascinating phenomenon whereby animals exposed to sub-lethal or mild insults develop protection against subsequent severe insults. His lab has developed a mouse model of ischaemic preconditioning which is used extensively in their research efforts. ArshadOther interests and areas of collaboration include: large animal (ovine) models of stroke, clinical outcomes research, clinical trials, stroke epidemiology and translational bioengineering.

近期论文

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Majid, A., Bae, O. N., Redgrave, J., Teare, D., Ali, A., & Zemke, D. (2015). The potential of adaptive design in animal studies. Int J Mol Sci, 16(10), 24048-24058. Baek SH, Noh AR, Kim KA, Akram M, Shin YJ, Kim ES, Yu SY, Bae ON, Majid A (2014). Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke, 45(8),2438-2443. Majid A. Neuroprotection in Stroke: Past, Present, and Future. (2014). ISRN Neurol. 2014; 2014:515716. Kishore A, Vail A, Majid A, Dawson J, Lees KR, Tyrrell PJ, Smith CJ (2014) Detection of atrial fibrillation after ischemic stroke or transient ischemic attack: a systematic review and meta-analysis. Stroke 45(2):520-6. Bae ON and Majid A (2013) Role of histidine/histamine in carnosine-induced neuroprotection during ischemic brain damage. Brain Research, 1527:246-254. Rayepalli S, Gupta R, Lum C, Majid A, Koochesfahani, M (2013). Metal to surface area thresholds to reduce flow in an in vitro side wall aneurysm. J Neuroimaging (4):495-501. Bhatt A, Safdar A, Chaudhari D, Clark D, Pollak A, Majid A, Kassab M. Medicolegal Considerations with Intravenous Tissue Plasminogen Activator in Stroke: A Systematic Review (2013). Stroke Res Treat. 2013:562564. Bae ON, Serfozo K, Baek SH, Lee KY, Dorrance A, Rumbeiha W, Fitzgerald SD, Farooq MU, Naravelta B, Bhatt A, Majid A (2013)Safety and efficacy evaluation of carnosine in ischemic stroke. Stroke (44) 1:205-2012. Ota H, Reeves M, Majid A, Collar, A, DeMarco K (2013) Gender Differences of High-Risk Carotid Atherosclerotic Plaque with Less Than 50% Stenosis in Asymptomatic Patients: An in vivo 3.0T MRI Study. AJNR 34(5):1049-55. Smith CR, Al-Nuaimi Y, Parry-Jones A, Wainwright J, Majid A. The influence of bolus to infusion delays on plasma Tissue Plasminogen Activator levels. Int J of Stroke in press.