Ince, Paul - University of Sheffield - Department of Neuroscience

个人简介

Appointments 1989-2000 MRC Clinical Scientist, Senior Lecturer in Neurochemical Pathology (University of Newcastle upon Tyne) and Honorary Consultant Neuropathologist 1982-1989 Lecturer in Pathology, University of Newcastle upon Tyne 1979-1982 Demonstrator in Pathology, University of Newcastle upon Tyne

研究领域

Prof Ince’s main research interests are in brain ageing, neurodegeneration, vascular disease and motor system disorders. He is the lead neuropathologist for the MRC Cognitive Function and Ageing Study (CFAS) and has collaborated with Prof Shaw on human neuropathology studies of ALS and other motor disorders for more than 20 years. The CFAS Neuropathology study has delivered a series of high profile papers defining the relationship between brain pathology and cognition in a large ageing population-based cohort. Project work has included characterisation of the pathology and pathophysiology of age-related white matter lesions in the human brain, the prevalence and significance of synucleinopathy in the elderly and many other facets of brain ageing and dementia. The CFAS project has been continuously funded by MRC for 26 years. Professor Ince directs the Sheffield Brain Tissue Bank (SBTB) that forms a central resource for human neuroscience research in Sheffield based on the characterisation of human brain tissue donated by patients and the public. SBTB has underpinned numerous studies in ALS/MND and other human motor system diseases.

近期论文

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McKeith IG., Ballard CG., Perry RH., Ince PG., O'Brien JT., Neill D., Lowery K., Jaros E., Barber R., Thompson P., Swann A., Fairbairn AF., Perry EK. Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology. 54: 1050-8 (2000) White KD. Ince PG. Lusher M. Lindsey J. Cookson M. Bashir R. Shaw PJ. Bushby KM. Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation. Neurology. 55: 89-94 (2000) Neuropathology Group of the MRC CFAS [writing committee: Esiri MM, Matthews F, Brayne C, Ince PG] Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357: 169-175 (2001) Curtis, A.R.J., Fey, C., Morris, C.M., Bindoff, L.A., Ince, P.G., Chinnery, P.F., Coulthard, A., Jackson, M.J., Jackson, A.P., McHale, D.P., Hay, D., Barker, W.A., Markham, A.F., Bates, D., Curtis, A., Burn, J. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset neurodegeneration. Nature Genetics 28: 327-334 (2001) Cottrel, D.A., Ince, P.G., Wardell, T.M., Turnbull, D.M., Johnson, M.A. Accelerated ageing changes in the choroids plexus of a case with multiple mitochondrial DNA deletions. Neuropathol Appl Neurobiol 27: 206-215 (2001) Munch C., Penndorf A., Schwalenstocker B., Troost D., Ludolph A.C., Ince P., Meyer T., Impaired RNA splicing of 5'-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma. J Neurol Neurosurg Psychiatry. 71:675-8 (2001). Cottrell D.A., Blakely E.L., Johnson M.A., Ince P.G., Turnbull D.M. Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD. Neurology 57:260-4 (2001). Banner S.J., Fray A.E., Ince P.G., Steward M., Cookson M.R., Shaw P.J. The expression of the glutamate re-uptake transporter Excitatory Amino Acid Transporter 1 (EAAT1) in the normal human CNS and in motor neurone disease: an immunohistochemical study. Neuroscience 109: 27-44 (2002)