Grierson, Andy - University of Sheffield - Department of Neuroscience

个人简介

2009 –present: Senior Lecturer 2001 - 2008: Lecturer, University of Sheffield 1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London 1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands 1991 - 1994: PhD (Molecular Genetics) University of Sheffield 1988 - 1991: BSc (Genetics) University of Sheffield

研究领域

Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP). In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.

近期论文

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Bennett, E. J., Mead, R. J., Azzouz, M., Shaw, P. J., & Grierson, A. J. (2014). Early Detection of Motor Dysfunction in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Using Home Cage Running Wheels. PLoS ONE, 9(9), e107918. doi:10.1371/journal.pone.0107918 Allen, S. P., Rajan, S., Duffy, L., Mortiboys, H., Higginbottom, A., Grierson, A. J., & Shaw, P. J. (2013). Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2013.11.025 Hewamadduma, C. A. A., Grierson, A. J., Ma, T. P., Pan, L., Moens, C. B., Ingham, P. W., et al. (2013). Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish. Human Molecular Genetics. doi:10.1093/hmg/ddt082 Hameed, A., Bennett, E., Ciani, B., Hoebers, L. P. C., Milner, R., Lawrie, A., et al. (2013). No evidence for cardiac dysfunction in kif6 mutant mice. PLoS ONE, 8(1), e54636. doi:10.1371/journal.pone.0054636 Chapman, A. L., Bennett, E. J., Ramesh, T. M., De Vos, K. J., & Grierson, A. J. (2013). Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish. PLoS ONE, 8(6), e67276. doi:10.1371/journal.pone.0067276 Abstract