Garwood, Claire - University of Sheffield - Department of Neuroscience

个人简介

2015-present: Alzheimer Society Junior Research Fellow 2011-2015: Post-doctoral Research Associate 2007-2010: PhD (Neuroscience), Institute of Psychiatry, Kings College London. 2009-2010: Research Assistant, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, Kings College London. I obtained my PhD in Neuroscience from Kings College London in 2010 where I determined that astrocytes mediate many of the toxic effects of beta-amyloid, one of the pathological proteins implicated in Alzheimer’s disease pathogenesis, and that minocycline was able to reduce the inflammatory response of astrocytes in Alzheimer’s disease models (Garwood et al., Cell Death Dis 2.e167; Garwood et al., Front. Psychiatry 1:136; Noble et al., FASEB J. 23(3): 739-750.) After completing my PhD I moved to the Sheffield Institute for Translational Neuroscience to continue investigating the role of astrocytes in Alzheimer’s disease pathogenesis as a post-doctoral research associate with Prof. Stephen Wharton. I have recently been awarded an Alzheimer’s Society Junior Research Fellowship based within the Sheffield Institute for Translational Neuroscience (SITraN) to continue working on the role astrocytes in Alzheimer’s disease and to develop a 3D astrocyte-neuron co-culture system in collaboration with Prof. John Haycock in the Department of Bioengineering.

研究领域

My research is focused on understanding the role of astrocytes in neurodegeneration, particularly their contribution to Alzheimer’s disease development and progression. In particular I am investigating how alterations in specific astrocytic signalling pathways compromises their function and their ability to support neurons.

近期论文

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Garwood CJ, Ratcliffe LE, simpson JE, Heath PR, Ince PG & Wharton SB (2016) Astrocytes in Alzheimer’s disease and other age-associated dementias; a supporting player with a central role. Neuropathology and Applied Neurobiology. View this article in WRRO Simpson JE, Ince PG, Minett T, Matthews FE, Heath PR, Shaw PJ, Goodall E, Garwood CJ, Ratcliffe LE, Brayne C, Rattray M & Wharton SB (2016) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology, 42(2), 167-179. View this article in WRRO Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE & Wharton SB (2015) A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLOS ONE, 10(2), e0118463-e0118463. View this article in WRRO Fluteau A, Ince PG, Minett T, Matthews FE, Brayne C, Garwood CJ, Ratcliffe LE, Morgan S, Heath PR, Shaw PJ, Wharton SB & Simpson JE (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609, 11-17. View this article in WRRO Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG & Wharton SB (2015) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8(1). View this article in WRRO Simpson JE, Ince PG, Matthews FE, Shaw PJ, Heath PR, Brayne C, Garwood C, Higginbottom A & Wharton SB (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41(4), 483-496. View this article in WRRO