Allen, Scott - University of Sheffield - Department of Neuroscience

个人简介

My main research focus is how motor neurone disease (MND) affects the major energy generation pathways in the central nervous system (CNS). Specifically; 1. How MND effects metabolic pathway regulation and interaction. 2. How metabolism responds to disease specific cellular stress such as oxidative stress and hypoxia. 3. How the disease affects the metabolic response to aging in patients. The long term goals of this research are to identify metabolic biomarkers of disease, uncover therapeutic targets and develop energy supplementation regimes for MND patients.

研究领域

My main research focus is how motor neurone disease (MND) affects the major energy generation pathways in the central nervous system (CNS). Specifically; 1. How MND effects metabolic pathway regulation and interaction. 2. How metabolism responds to disease specific cellular stress such as oxidative stress and hypoxia. 3. How the disease affects the metabolic response to aging in patients. The long term goals of this research are to identify metabolic biomarkers of disease, uncover therapeutic targets and develop energy supplementation regimes for MND patients.

近期论文

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Altered age related changes in bioenergetic properties and mitochondrial morphology in fibroblast from sporadic amyotrophic lateral sclerosis (SALS). Allen SP, Duffy L, Shaw PJ, and Grierson AJ. Neurobiol. Aging. 2015. 36: 2893-903 Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions. Raman R and Allen SP, Goodall EF, Kramer S, Ponger LL, Heath PR, Milo M, Hollinger HC, Walsh T, Highley JR, Olpin S, McDermott CJ, Shaw PJ, Kirby J. Neuropathol. Appl. Neurobiol. 2015. 41:201-26 Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis. Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ, Shaw PJ. Neurobiol. Aging. 2014. 35:1499-509. The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type. Richardson K, and Allen SP, Mortiboys H, Grierson AJ, Wharton SB, Ince PG, Shaw PJ, Heath PR. PLoS One. 2013. 28:e68256. S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I, Brancale A, Grierson AJ, Shaw PJ. Free Radic. Biol. Med. 2013. 61:438-52.