Thomas, Jim A. - University of Sheffield

个人简介

Prof. Thomas obtained a BSc in Chemistry from the University of Reading in 1982 and a PhD from the University of Birmingham in 1993. After his PhD he became a Royal Society European Exchange Fellow at the Universite Louis Pasteur in Strasbourg in 1993, followed by a postdoctoral fellowship at the University of Sheffield in 1994. In 1995 he was appointed as a Royal Society University Research Fellow. In 2004 he was appointed lecturer and promoted to senior lecturer (2007), reader (2010), and professor (2015)

研究领域

My group is particularly interested in using photochemically and/or electrochemically active metal centres to produce functional molecular architectures. Most of our work is inspired in some way by biological systems. For example, by using a combination of hydrogen and coordination bonding we are investigating the metal-ion directed self-assembly of hosts and sensors for anions, bioanions and biomolecules. Using a similar approach we are creating hosts that function as molecular devices such as ion-gated switches. Finally, we are very interested at the way oligonuclear luminescent coordination complexes interact with biomolecules such as DNA. This work includes in cellulo studies aimed at identifying new optical imaging probes with multiple output modalities and also potential novel therapeutic leads.

近期论文

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Song L, Guo Y, Roebuck D, Chen C, Yang M, Yang Z, Sreedharan S, Glover C, Thomas JA, Liu D, Guo S, Chen R & Zhou D (2015) Terminal PEGylated DNA–Gold Nanoparticle Conjugates Offering High Resistance to Nuclease Degradation and Efficient Intracellular Delivery of DNA Binding Agents. ACS Applied Materials & Interfaces, 7(33), 18707-18716. View this article in WRRO Zubi A, Wragg A, Turega S, Adams H, Costa PJ, Félix V & Thomas JA (2015) Correction: Modulating the electron-transfer properties of a mixed-valence system through host–guest chemistry. Chem. Sci., 6(7), 4373-4374. Thomas JA (2015) Optical imaging probes for biomolecules: an introductory perspective. Chemical Society Reviews, 44(14), 4494-4500. View this article in WRRO Wragg A, Gill MR, McKenzie L, Glover C, Mowll R, Weinstein JA, Su X, Smythe C & Thomas JA (2015) Serum Albumin Binding Inhibits Nuclear Uptake of Luminescent Metal-Complex-Based DNA Imaging Probes. Chemistry - A European Journal, 21(33), 11865-11871. Zubi A, Wragg A, Turega S, Adams H, Costa PJ, Félix V & Thomas JA (2015) Modulating the electron-transfer properties of a mixed-valence system through host–guest chemistry. Chem. Sci., 6(2), 1334-1340.