个人简介
Dr. Sarah Staniland obtained her MChem degree at the University of Edinburgh in 2001. This was followed by a PhD in magnetic materials (dept. Chemistry, Edinburgh) which she completed in 2005. After this she won an independent EPSRC life science interface fellowship (2005-2008) at the University of Edinburgh where she initiated the research she is currently active in. This helped her transition from the chemical material sciences to interdisciplinary work at the interface with biology. She then moved to the University of Leeds to take up a Lectureship in Bionanoscience in the School of Physics and Astronomy where she was promoted to Associate Professor (2008-2013). She has now moved to Sheffield as a Senior Lecturer in Bionanoscience.
研究领域
Our group seeks to synthesis novel precise bio/mineral nanomaterial architectures for nanotechnological and biomedical applications. Inspired by nature, we are using functional proteins such as biomineralisation proteins and lipid membrane to create hybrid functional nanomaterial and arrays. The main interest is the formation of membrane surrounded magnetite nanoparticles. These are biomineralised in nature within magnetic bacteria and are termed magnetosomes. Currently we are working on a number of projects such as:
using genetic engineering and transition metal solution chemistry to alter and enhance the magnetosome particles in vivo;
using the magnetic bacterial Mms proteins to control the synthesis of enhanced and functional magnetite nanoparticles in vitro;
performing these biomimetic formations on surfaces in organised and functional arrays;
using these and lipid membranes to surround the particles and attach them to surfaces;
Use physical and biological probes to analysis how these biomineralisation protein actually control this process so precisely.
The research is intrinsically multi-disciplinary, spanning: magnetic characterisation, chemical synthesis, nanotechnological engineering, proteomics, genetics, environmental, and micro-biology.
近期论文
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Bakhshi PK, Bain J, Gul MO, Stride E, Edirisinghe M & Staniland SS (2016) Manufacturing Man-Made Magnetosomes: High-Throughput In Situ Synthesis of Biomimetic Magnetite Loaded Nanovesicles. Macromolecular Bioscience, 16(11), 1555-1561. View this article in WRRO
Staniland SS & Rawlings AE (2016) Crystallizing the function of the magnetosome membrane mineralization protein Mms6. Biochemical Society Transactions, 44(3), 883-890. View this article in WRRO
Galloway JM, Bird SM, Talbot JE, Shepley PM, Bradley RC, El-Zubir O, Allwood DA, Leggett GJ, Miles JJ, Staniland SS & Critchley K (2016) Nano- and micro-patterning biotemplated magnetic CoPt arrays. Nanoscale, 8(22), 11738-11747. View this article in WRRO
Tanaka M, Knowles W, Brown R, Hondow N, Arakaki A, Baldwin S, Staniland S & Matsunaga T (2016) Biomagnetic recovery of selenium: Bioaccumulating of selenium granules in magnetotactic bacteria. Applied and Environmental Microbiology, 82(13), 3886-3891. View this article in WRRO
Rawlings AE, Bramble JP, Hounslow AM, Williamson MP, Monnington AE, Cooke DJ & Staniland SS (2016) Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy. Chemistry - A European Journal, 22(23), 7885-7894. View this article in WRRO
Rawlings AE, Bird SM, Galloway JM & Staniland SS (2016) Using a biomimetic membrane surface experiment to investigate the activity of the magnetite biomineralisation protein Mms6. RSC Advances. View this article in WRRO