Jones, Simon - University of Sheffield - Department of Chemistry

个人简介

Dr. Jones obtained a BSc in Chemistry from the University of Southampton (1991). After obtaining his PhD from the University of Wales, Cardiff in 1995, he became a postdoctoral research associate at Arizona State University. Between 1996 and 1998 he was a postdoctoral research assistant in the Dyson Perrins Laboratory at the University of Oxford. In 1999 he was appointed to a lecturership at the University of Newcastle upon Tyne. In 2003 he moved to the University of Sheffield, where he was promoted to Senior Lecturer in 2005 and Reader in 2013.

研究领域

Methods for Asymmetric Synthesis A major theme of a majority of my research is the development of new ways to construct molecules in a controlled and selective fashion. We have established innovative methods based on chiral anthracene templates, organocatalysts and organo-boron and phosphorus species. Construction of Molecular Probes of Biologically Active Molecules A number of projects are underway that involve the synthesis of new, functional molecules that can be used to probe biochemical pathways. Current projects involve the development of new magnetic imaging contrast agents, fluorescent probes based upon fatty acids and bisphosphonates, and 13C labeled anti-cancer agents for use in dynamic nuclear polarisation studies. Synthesis of Biologically Active Molecules Several projects are underway involving the design, synthesis, and biological testing of molecules that could be used as potential novel anti-inflammatory agents and antibiotics. Another project is similarly looking at ways to develop a new herbicide.

近期论文

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Renshaw SA, robertson A, ogryzko N, Henry K, Loynes C, foulkes M, meloni M, Wang X, Ford C, Jackson M, Ingham P, Wilson H, Farrow S, Solari R, Flower R, Jones S & Whyte M (2016) Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. DMM Disease Models and Mechanisms, 9, 621-632. View this article in WRRO Warner CJA, Reeder AT & Jones S (2016) P-Chiral phosphine oxide catalysed reduction of prochiral ketimines using trichlorosilane. Tetrahedron: Asymmetry, 27(2-3), 136-141. Collins RC, Paley MN, Tozer GM & Jones S (2016) Synthesis of [3-13C]-2,3-dihydroxy-4-methoxybenzaldehyde. Tetrahedron Letters, 57(5), 563-565. View this article in WRRO Kutama IU & Jones S (2015) Enantioselective Desymmetrization of Glutarimides Catalyzed by Oxazaborolidines Derived from cis -1-Amino-indan-2-ol. The Journal of Organic Chemistry, 80(22), 11468-11479. View this article in WRRO Bawa RA, Gautier F-M, Adams H, Meijer AJHM & Jones S (2015) Evaluating hydrogen bonding control in the diastereoselective Diels–Alder reactions of 9-(2-aminoethyl)-anthracene derivatives. Org. Biomol. Chem., 13(42), 10569-10577. View this article in WRRO Crook S, Parr NJ, Simmons J & Jones S (2014) Examining the origin of selectivity in the reaction of racemic alcohols with chiral N-phosphoryl oxazolidinones. Tetrahedron: Asymmetry, 25(18-19), 1298-1308. View this article in WRRO