Jackson, Richard F. W. - University of Sheffield

个人简介

Prof. Jackson obtained his BA in Chemistry from the University of Cambridge in 1981. After his PhD (Cambridge 1984) he became a Postdoctoral Research Fellow at the ETH in Zürich, Switzerland. In 1985 he was appointed to a lectureship at the University of Newcastle, where he was promoted to Reader in 1994 and to Professor in Synthetic Organic Chemistry in 1996. In 2001 he was appointed to a Chair in Synthesis at the University of Sheffield. He served as Head of the Department of Chemistry from 2003-2007 and has returned to this role for a further term (2011-2014).

研究领域

I carried out research for my PhD under the supervision of the late Professor Ralph Raphael. I developed a new route to dihydrofuranones, and completed a synthetic approach to the Pseudomonic acids. With this training in target synthesis, I spent one year at the ETH, Zürich, working with Professor Dieter Seebach on the synthesis of a derivative of the macrodiolide Elaiophylin. I returned to the UK in 1985 to take up a lectureship in Newcastle. Our initial work was in nucleophilic epoxidation, and epoxide anion chemistry, but we also initiated a programme in the area of unnatural amino acid synthesis. We found that organozinc derivatives of amino acids could be prepared, were surprisingly stable, and provided an easy route to a large variety of useful compounds. This latter area blossomed, and resulted in various awards, from Pfizer, Zeneca and the Hickinbottom Fellowship of the Royal Society of Chemistry. ZincReagents More recently, we have extended our research to the area of asymmetric catalysis, and discovered a simple method for the asymmetric epoxidation of enones, and a highly efficient method for the asymmetric oxidation of alkyl aryl sulfides to the corresponding sulfoxides. We are also interested in solid phase chemistry, and the application of combinatorial techniques to the discovery of new catalysts.

近期论文

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Jackson RF, adams H & salih N (2016) Synthesis of ω-Oxo Amino Acids and trans-5-Disubstituted Proline Derivatives using Cross-methathesis of Unsaturated Amino Acids. Journal of Organic Chemistry. View this article in WRRO Lilley M, Mambwe B, Thompson MJ, Jackson RFW & Muimo R (2015) 4-Phosphopyrazol-2-yl alanine: a non-hydrolysable analogue of phosphohistidine. Chem. Commun., 51(34), 7305-7308. View this article in WRRO Lilley M, Mambwe B, Jackson RF & Muimo R (2014) 4-Phosphothiophen-2-yl alanine: a new 5-membered analogue of phosphotyrosine.. Chem Commun (Camb), 50(66), 9343-9345. View this article in WRRO Wuttke C, Ford R, Lilley M, Grabowska U, Wiktelius D & Jackson RFW (2012) New routes to lipophilic amino acids: Synthesis of alkynyl and fluoro-containing alanine derivatives. Synlett(2), 243-246. Massah AR, Dreiocker F, Jackson RF, Pickup BT, Oomens J, Meijer AJ & Schäfer M (2011) Gas-phase study of new organozinc reagents by IRMPD-spectroscopy, computational modelling and tandem-MS.. Phys Chem Chem Phys, 13(29), 13255-13267. Ross AJ, Dreiocker F, Schäfer M, Oomens J, Meijer AJ, Pickup BT & Jackson RF (2011) Evidence for the role of tetramethylethylenediamine in aqueous Negishi cross-coupling: synthesis of nonproteinogenic phenylalanine derivatives on water.. J Org Chem, 76(6), 1727-1734. Massah AR, Ross AJ & Jackson RF (2010) In situ trapping of Boc-2-pyrrolidinylmethylzinc iodide with aryl iodides: direct synthesis of 2-benzylpyrrolidines.. J Org Chem, 75(23), 8275-8278.