Harrity, Joseph P. A. - University of Sheffield

个人简介

Prof. Harrity obtained his BSc (Hons.) in Chemistry from the University of Strathclyde in 1991, followed by a PhD from the same institution in 1994. He was a Postdoctoral Research Fellow at Boston College, USA from 1994 to 1997, after which he became a Lecturer at the University of Sheffield. Here he was promoted to Senior Lecturer and Reader. He was promoted to Professor in 2009. In October 2012, Prof. Harrity was appointed to a 3 year Royal Society Industry Fellowship to undertake a collaboration with Peakdale Molecular. He will work with Peakdale to develop novel functionalised intermediates on commercially relevant scales, thereby introducing new scaffolds into their catalogue portfolio.

研究领域

Synthesis provides the opportunity to design and prepare specific molecules whilst exploring novel processes that further develop the field of organic chemistry. In this context, our programme has concentrated on new and selective carbon-carbon bond forming strategies for the preparation of functionalised synthetic Intermediates. A summary of projects currently under investigation is outlined below: Alkynylboronate Cycloadditions. Aromatic boronic acids and esters are extremely useful and versatile substrates in modern organic chemistry. We have developed a strategically novel approach to these compounds through cycloaddition reactions of alkynylboronates. To date, this approach has allowed us to generate boronic esters that are connected to benzene, quinone, pyridine, pyrazole, isoxazole and pyridazine scaffolds. [3 + 3] Annelation Reactions. We have designed an efficient method for the synthesis of piperidines and pyrans by the addition of conjunctive reagents to aziridines and epoxides. Moreover, the ready availability of enantiopure aziridnes/epoxides has allowed to us to employ this technique in the stereoselective synthesis of alkaloid natural products, as well as bioactive compounds of marine origin.Research Harrity 2 Organocobalt complexes. A Lewis acid catalysed rearrangement reaction of cobalt-alkyne complexes bearing a cyclic enol ether unit has been developed that provides a direct and stereoselective route to 3-alkynylcycloalkanones. A catalytic variant of this process is currently under investigation as is its employment in target synthesis.

近期论文

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Comas-Barceló J & Harrity JPA (2016) Metal Acetylides in Cycloaddition Reactions. Synthesis. Maiden TMM, Swanson S, Procopiou PA & Harrity JPA (2016) Oxazoline-Promoted Rh-Catalyzed C–H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study. The Journal of Organic Chemistry, 81(22), 10641-10650. View this article in WRRO Brown AW, Fisher M, Tozer GM, Kanthou C & Harrity JP (2016) A Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4.. J Med Chem. View this article in WRRO Allen BDW, Connolly MJ & Harrity JPA (2016) Frontispiece: A Pd-Catalyzed Synthesis of Functionalized Piperidines. Chemistry - A European Journal, 22(37). View this article in WRRO Maiden TMM & Harrity JPA (2016) Recent developments in transition metal catalysis for quinazolinone synthesis. Org. Biomol. Chem.. View this article in WRRO Bachollet SPJT, Volz D, Fiser B, Münch S, Rönicke F, Carrillo J, Adams H, Schepers U, Gómez-Bengoa E, Bräse S & Harrity JPA (2016) A Modular Class of Fluorescent Difluoroboranes: Synthesis, Structure, Optical Properties, Theoretical Calculations and Applications for Biological Imaging. Chemistry - A European Journal, 22(35), 12430-12438. View this article in WRRO Comas-Barceló J, Blanco-Ania D, van den Broek SAMW, Nieuwland PJ, Harrity JPA & Rutjes FPJT (2016) Cu-catalysed pyrazole synthesis in continuous flow. Catal. Sci. Technol., 6(13), 4718-4723. View this article in WRRO Maiden TM, Swanson S, Procopiou PA & Harrity JP (2016) Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction.. Organic Letters. View this article in WRRO