Ciani, Barbara - University of Sheffield

个人简介

Dr. Ciani obtained a Laurea in Chemistry at University "La Sapienza", Rome in 1997. This was followed by a DPhil in Biochemistry at the University of Sussex in Brighton in 2001, after which she became a Postdoctoral Research Associate at the University of Nottingham (2001-2003) and subsequently at the University of Manchester (2004-2008). In 2008 she was appointed as a Lecturer in Biophysical Chemistry at the University of Sheffield.

研究领域

Protein-protein interactions are essential to ensure correct function of all living organisms. One of the means for regulating protein-protein interactions is through coiled coil domains. Coiled coils are oligomerisation domains present in a large variety of proteins that play major roles in almost all biological processes. The most attractive feature of coiled coils is that their multimerisation properties can be `programmed´ by their amino acid sequences. Research in our lab focuses specifically in two main areas: Research Barbara Ciani Protein designers are trying to learn how natural coiled coil systems can be exploited to create novel functional self-assembled structures for medicine and material science applications. We are interested in the elucidation of molecular features that control coiled coil oligomerisation specificity using simple leucine zipper domains as model systems. Diseases such as cancer and neurodegeneration are caused by malfunction of cellular pathways involved in degradation of non-functional proteins. We want to understand how coiled coil motifs regulate the assembly of specific protein complexes that work in the transport of cargo destined for degradation.

近期论文

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Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G, Wright F, Akil M, Fearon U, Veale D, Ciani B & Wilson AG (2015) C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Proceedings of the National Academy of Sciences, 112(37), 11618-11623. View this article in WRRO Beales PA & Ciani B (2015) Chemical compartmentalisation by membranes: from biological mechanism to biomimetic applications. Phys. Chem. Chem. Phys., 17(24), 15487-15488. Beales PA, Ciani B & Cleasby AJ (2015) Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. Phys. Chem. Chem. Phys., 17(24), 15489-15507. View this article in WRRO Muthana M, Hawtree S, Davies H, Roberts H, Khetan S, Akil M, Wright F, Ciani B, Fearon U, Veale DJ & Wilson AG (2014) C5orf30 a Novel Regulator of Inflammation and Tissue Damage in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, 66, S1222-S1222. Patel N, Exell JC, Jardine E, Ombler B, Finger LD, Ciani B & Grasby JA (2013) Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing. J. Biol. Chem.. View this article in WRRO Jackson MP, Louth J, Thompson MJ, Ciani B & Chen B (2013) Anti prion molecules and their interaction with amyloid beta. PRION, 7, 77-77. Hameed A, Bennett E, Ciani B, Hoebers LP, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) No evidence for cardiac dysfunction in Kif6 mutant mice.. PLoS One, 8(1), e54636. View this article in WRRO Ciani B, Bjelic S, Honnappa S, Jawhari H, Jaussi R, Payapilly A, Jowitt T, Steinmetz MO & Kammerer RA (2010) Molecular basis of coiled-coil oligomerization-state specificity.. Proc Natl Acad Sci U S A, 107(46), 19850-19855. Steinmetz MO, Gattin Z, Verel R, Ciani B, Stromer T, Green JM, Tittmann P, Schulze-Briese C, Gross H, van Gunsteren WF, Meier BH, Serpell LC, Müller SA & Kammerer RA (2008) Atomic models of de novo designed cc beta-Met amyloid-like fibrils.. J Mol Biol, 376(3), 898-912.