Baggaley, Elizabeth - University of Sheffield

个人简介

Dr. Baggaley studied at the University of Sheffield obtaining a MChem with a year in industry in 2008 and a PhD in inorganic chemistry and bio-imaging in 2012. She worked for one year as a postdoctoral researcher between Prof. John Haycock (Materials Science and Engineering) and Prof. Julia Weinstein (Chemistry) at Sheffield. In 2013 she changed research field working with Prof. Mike Ward on supramolecular co-ordination cages. In 2014 she was appointed as a research and teaching associate at the University of Sheffield.

研究领域

My research interests focus on the development of luminescent transition metal complexes for bio-imaging applications. In particular, using bio-conjugation to create ligand architectures that will form water soluble transition metal complexes that localise in specific organelles of mammalian cells. We are interested in how these complexes behave in vitro and in solution; what are their emission properties (profile and lifetime) and how do they change with temperature, pH, solvent and O2 concentration. The main themes we are exploring are: Oxygen sensing and quantification using transition metal complexes and phosphorescence lifetime emission microscopy. Revealing the detail of cellular localisation of transition metal dyes using super resolution techniques. The research is intrinsically multi-disciplinary spanning: inorganic synthetic chemistry, spectroscopy, microscopy and cell biology.

近期论文

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McKenzie L, Sazanovich I, Baggaley E, Bonneau M, Guerchais V, Williams G, Weinstein J & Bryant HE (2016) Metal Complexes For Two-photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-photon Photosensitization of Cancer Cells Under Near-IR Light.. Chemistry. View this article in WRRO Jana A, Crowston BJ, Shewring JR, McKenzie LK, Bryant HE, Botchway SW, Ward AD, Amoroso AJ, Baggaley E & Ward MD (2016) Heteronuclear Ir(III)–Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing. Inorganic Chemistry, 55(11), 5623-5633. View this article in WRRO Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA & Bryant HE (2016) Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand. Scientific Reports, 6, 22668-22668. View this article in WRRO Jana A, McKenzie L, Wragg AB, Ishida M, Hill JP, Weinstein JA, Baggaley E & Ward MD (2016) Porphyrin/Platinum(II) C^N^N Acetylide Complexes: Synthesis, Photophysical Properties, and Singlet Oxygen Generation. Chemistry - A European Journal, 22(12), 4164-4174. View this article in WRRO Baggaley E, Weinstein JA & Williams JAG (2015) Time-Resolved Emission Imaging Microscopy Using Phosphorescent Metal Complexes: Taking FLIM and PLIM to New Lengths. Structure and Bonding, 165, 205-256. Baggaley E, Weinstein JA & Williams JAG (2015) Time-Resolved Emission Imaging Microscopy Using Phosphorescent Metal Complexes: Taking FLIM and PLIM to New Lengths. Structure and Bonding, 165, 205-256. Jana A, Baggaley E, Amoroso A & Ward MD (2015) A new ligand skeleton for imaging applications with d–f complexes: combined lifetime imaging and high relaxivity in an Ir/Gd dyad. Chem. Commun., 51(42), 8833-8836. View this article in WRRO