Levkin, Pavel - Karlsruhe Institute of Technology - Institute of Biological and Chemical

个人简介

Education and Research Experience Current positions Professor (W3) Head of research group of Biofunctional Materials Karlsruhe Institute of Technology (Germany) Institute of Biological and Chemical Systems (IBCS-FMS) und Institute of Organic Chemistry (IOC) 2020-present Group leader Itmo University, ST. Petersburg (Russia) SCAMT institute (Solution Chemistry of Advanced Materials and Technologies) 01.12.2021 - 24.02.2022 Co-founder AQUARRAY Development and commercialization of a miniaturized platform for cell experiments, personalized medicine, and drug discovery 2018-present CSO SCREENFECT Development and commercialization of synthetic gene delivery vectors for biological and biomedical applications 2016-present Previous positions Principal investigatorKarlsruhe Institute of Technology (Germany)Institute of Toxicology and Genetics and Institute of Organic Chemistry 2009-2019 Group leader Ruprecht-Karls University Heidelberg (Germany)Institute of Applied Physical Chemistry with Prof. (em.) Grunze 2009-2014 Education Postdoc University of California, Berkeley, USA Group of Prof. J.M.J. Fréchet and Dr. F. Svec 2007-2009 Visiting scientist University of Vienna, Austria Group of Prof. Wolfgang Lindner 2006 Ph.D Chemistry University of Tübingen, Germany Group of Prof. Volker Schurig Organic and Analytical Chemistry 2003 – 2007 B.Sc. and M.Sc. Chemistry and Chemical Engineering (with honors) Institute of Chemical Physics, Russian Academy of Sciences and Moscow Institute of Fine Chemical Technology Group of Prof. Rem Kostyanovsky

研究领域

Functional materials and interface systems play an increasingly important role in biology, in the advancement of biotechnology, regenerative and personalized medicine, cell biology, stem cell research, drug delivery, microfluidics and tissue engineering. Further understanding of basic mechanisms behind development of functional materials systems and further advancement of these research fields will improve our healthcare system and increase life expectancy. In our research group at the KIT, we design, develop and apply biologically functional, dynamic and responsive materials, interfaces and materials systems. We work on the development of various materials systems and methods, including: (1) porous polymers with controlled surface topography, porosity and wettability (2) hydrogels and organogels with various biologically relevant and responsive properties (3) nanostructured interfaces and 3D printed materials (4) surface functionalization approaches, including photoclick reactions, polydopamine and polyphenolic coatings (5) methods enabling miniaturization, parallelization and combination of organic synthesis and biological experiments (6) materials and surfaces with special wettability.

近期论文

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Palladium‐Catalyzed Combinatorial Synthesis of Biphenyls on Droplet Microarrays at Nanoliter Scale Julius Höpfner, Marius Brehm, Pavel A Levkin Small, 2304325 High‐Performance Pressure Sensors Based on Shaped Gel Droplet Arrays Zhenwu Wang, Qianyu Cai, Lutong Lu, Pavel A Levkin Small, 2305214 Diapers to Thickeners and Pressure-Sensitive Adhesives: Recycling of Superabsorbers via UV Degradation Shuai Li, Johannes M. Scheiger, Zhenwu Wang, Birgit Huber, Maxi Hoffmann, Manfred Wilhelm, and Pavel A. Levkin ACS Appl. Mater. Interfaces 2023, 15, 37, 44186–44193 3D-Printed Inherently Porous Structures with Tetrahedral Lattice Architecture: Experimental and Computational Study of Their Mechanical Behavior Maria A Kuzina, Chantal M Kurpiers, Ya‐Yun Tsai, Ruth Schwaiger, Shu‐Wei Chang, Pavel Levkin Macromolecular Materials and Engineering, 2300041 High-Throughput Synthesis and Machine Learning Assisted Design of Photodegradable Hydrogels Maximilian Seifermann, Patrick Reiser, Pascal Friederich, Pavel A Levkin Small Methods, 2300553 Electrical Conductivity and Photodetection in 3D-Printed Nanoporous Structures via Solution-Processed Functional Materials Kai Xia, Zheqin Dong, Qing Sun, Rafaela Debastiani, Sida Liu, Qihao Jin, Yang Li, Ulrich W Paetzold, Peter Gumbsch, Uli Lemmer, Yolita M Eggeler, Pavel A Levkin, Gerardo Hernandez‐Sosa Advanced Materials Technologies, 2300408 Fabrication of Omniphobic-Omniphilic Micropatterns using GPOSS-PDMS Coating Dmitrii D Kartsev, Artur Y Prilepskii, Ilia M Lukyanov, Eduard G Sharapenkov, Anastasiia V Klaving, Aleksandr Goltaev, Alexey Mozharov, Liliia Dvoretckaia, Ivan Mukhin, Pavel A Levkin Advanced Materials Interfaces, 2300156 Tough PEGgels by In Situ Phase Separation for 4D Printing Z Wang, M Heck, W Yang, M Wilhelm, PA Levkin Advanced Functional Materials, 2300947 Organogels versus Hydrogels: Advantages, Challenges, and Applications Mariia A Kuzina, Dmitrii D Kartsev, Alexander V Stratonovich, Pavel A Levkin Advanced Functional Materials, 2301421 Repurposing FDA-Approved Drugs for Temozolomide-resistant IDH1 Mutant Glioma using High-Throughput Miniaturized Screening on Droplet Microarray Chip Haijun Cui, Xueyuan Sun, Marcel Schilling, Christel Herold-Mende, Markus Reischl, Pavel A. Levkin, Anna A. Popova, Şevin Turcan Advanced Healthcare Materials, e2300591 Automated high-throughput image processing as part of the screening platform for personalized oncology Marcel P Schilling, Razan El Khaled El Faraj, Joaquín Eduardo Urrutia Gómez, Steffen J Sonnentag, Fei Wang, Britta Nestler, Véronique Orian-Rousseau, Anna A Popova, Pavel A Levkin, Markus Reischl Scientific Reports 13 (1), 5107 3D Microprinting of Super-Repellent Microstructures: Recent Developments, Challenges, and Opportunities Zheqin Dong, Pavel A Levkin Advanced Functional Materials, 2213916 A colorfast and durable superamphiphobic coating based on organic-titanium fluoride nanoparticles and crystal violet lactone Weiyi Liu, Jiajun Liu, Yan Liu, Fei Shen, Li Zhao, Zheqin Dong, Zhenwu Wang, Gang Yang, Pavel A Levkin, Yanzong Zhang Applied Surface Science, 156366 Nanoliter Scale Parallel Liquid–Liquid Extraction for High‐Throughput Purification on a Droplet Microarray Janne J Wiedmann, Yelda N Demirdögen, Stefan Schmidt, Mariia A Kuzina, Yanchen Wu, Fei Wang, Britta Nestler, Carsten Hopf, Pavel A Levkin Small, 2204512 High‐throughput formation of miniaturized cocultures of 2D cell monolayers and 3D cell spheroids using droplet microarray Haijun Cui, Tina Tronser, Xianxian Wang, Janine Wesslowski, Gary Davidson, Anna A Popova, Pavel A Levkin Droplet, e39 Tough, Self-Healing, and Conductive Elastomer ─Ionic PEGgel Zhenwu Wang, Yu-cheng Lai, Ya-tang Chiang, Johannes Martin Scheiger, Shuai Li, Zheqin Dong, Qianyu Cai, Sida Liu, Shan-hui Hsu, Chia-ching Chou, Pavel A Levkin ACS Applied Materials & Interfaces 14 (44), 50152-50162 Material-Independent 3D Patterning Via Two-Photon Lithography and Discontinuous Wetting Zheqin Dong, Joël Monti, Haijun Cui, Alexander Welle, Surya A Singaraju, Eva Blasco, Pavel A Levkin Advanced Materials Technologies, 2201268 Further Dimensions for Sensing in Biofluids: Distinguishing Bioorganic Analytes by the Salt-Induced Adaptation of a Cucurbit [7] uril-Based Chemosensor Changming Hu, Thomas Jochmann, Papri Chakraborty, Marco Neumaier, Pavel A Levkin, Manfred M Kappes, Frank Biedermann Journal of the American Chemical Society, 2022, 144, 29, 13084–13095 Droplet Microarray as a Powerful Platform for Seeking New Antibiotics Against Multidrug‐Resistant Bacteria Wenxi Lei, Anke Deckers, Charlotte Luchena, Anna Popova, Markus Reischl, Nicole Jung, Stefan Bräse, Thomas Schwartz, Ilga K Krimmelbein, Lutz F Tietze, Pavel A Levkin Advanced Biology, 2022, 2200166 A Reactive Superhydrophobic Platform for Living Photolithography Xinjian Xie, Xinghao Chen, Pavel A Levkin, Wenqian Feng Advanced Materials, 2022, 2203619 Droplet microarray based screening identifies proteins for maintaining pluripotency of hiPSCs Yanxi Liu, Sarah Bertels, Markus Reischl, Ravindra Peravali, Martin Bastmeyer, Anna A Popova, Pavel A Levkin Advanced Healthcare Materials, 2022, 2200718 Analytical Performance Evaluation of New DESI Enhancements for Targeted Drug Quantification in Tissue Sections Margaux Fresnais, Siwen Liang, Marius Breitkopf, Joshua Raoul Lindner, Emmanuelle Claude, Steven Pringle, Pavel A Levkin, Konstantin Demir, Julia Benzel, Julia Sundheimer, Britta Statz, Kristian W Pajtler, Stefan M Pfister, Walter E Haefeli, Jürgen Burhenne, Rémi Longuespée Pharmaceuticals, 2022, 15 (6), 694 Wavelength Orthogonal Photodynamic Networks Vinh X Truong, Katharina Ehrmann, Maximilian Seifermann, Pavel A Levkin, Christopher Barner‐Kowollik Chemistry-A European Journal, 2022, 28 (25), e202104466 Inverse Vulcanization of Norbornenylsilanes: Soluble Polymers with Controllable Molecular Properties via Siloxane Bonds Johannes M Scheiger, Maxi Hoffmann, Patricia Falkenstein, Zhenwu Wang, Mark Rutschmann, Valentin W Scheiger, Alexander Grimm, Klara Urbschat, Tobias Sengpiel, Jörg Matysik, Manfred Wilhelm, Pavel A Levkin, Patrick Theato Angewandte Chemie International Edition, 2022, 61 (16), e202114896 Tough, Transparent, 3D‐Printable, and Self‐Healing Poly (ethylene glycol)‐Gel (PEGgel) Zhenwu Wang, Haijun Cui, Modan Liu, Stephan L Grage, Maxi Hoffmann, Elaheh Sedghamiz, Wolfgang Wenzel, Pavel A Levkin Advanced Materials, 2022, 34 (11), 2107791 Simple assessment of viability in 2D and 3D cell microarrays using single step digital imaging Anna A Popova, Markus Reischl, Daniel Kazenmaier, Haijun Cui, Timo Amberger, Pavel A Levkin SLAS technology, 2022, 27(1), 44-53 Equilibrium droplet shapes on chemically patterned surfaces: theoretical calculation, phase-field simulation, and experiments Yanchen Wu, Mariia Kuzina, Fei Wang, Markus Reischl, Michael Selzer, Britta Nestler, Pavel A Levkin Journal of Colloid and Interface Science, 2022, 606, 1077-1086 “Cells-to-cDNA on Chip”: Phenotypic Assessment and Gene Expression Analysis from Live Cells in Nanoliter Volumes Using Droplet Microarrays Shraddha Chakraborty, Charlotte Luchena, Jonathan J. Elton, Marcel P. Schilling, Markus Reischl, Margaux Roux, Pavel A. Levkin, Anna A. Popova Advanced Healthcare Materials, 2022, 202102493 3D Printing of Superhydrophobic Objects with Bulk Nanostructure Zheqin Dong, Maja Vuckovac, Wenjuan Cui, Quan Zhou, Robin H. A. Ras, Pavel A. Levkin Advanced Materials, 2021, 202106068 Substrate-Independent and Re-Writable Surface Patterning by Combining Polydopamine Coatings, Silanization, and Thiol-Ene Reaction Shuai Li, Johannes M. Scheiger, Zhenwu Wang, Zheqin Dong, Alexander Welle, Vanessa Trouillet, Pavel A. Levkin Advanced Functional Materials, 2021, 2107716 Inherently UV Photodegradable Poly(methacrylate) Gels Johannes M. Scheiger, Shuai Li, Marius Brehm, Andreas Bartschat, Patrick Theato, Pavel A. Levkin Advanced Functional Materials, 2021, 2105681 Miniaturized Drug Sensitivity and Resistance Test on Patient-Derived Cells Using Droplet-Microarray Anna A. Popova, Sascha Dietrich, Wolfgang Huber, Markus Reischl, Ravindra Peravali, Pavel A. Levkin SLAS TECHNOLOGY: Translating Life Sciences Innovation 26 (3), 274-286 Facile Approach to Conductive Polymer Microelectrodes for Flexible Electronics Zhenwu Wang, Haijun Cui, Shuai Li, Xiaowei Feng, Jasmin Aghassi-Hagmann, Saeid Azizian, and Pavel A. Levkin ACS Appl. Mater. Interfaces, 2021, 13, 18, 21661–21668 Designing Inherently Photodegradable Cell-Adhesive Hydrogels for 3D Cell Culture Alisa Rosenfeld, Tobias Göckler, Mariia Kuzina, Markus Reischl, Ute Schepers, Pavel A. Levkin Advanced Healthcare Materials, 2021, 10(2100632) Droplet microarrays for cell culture: effect of surface properties and nanoliter culture volume on global transcriptomic landscape S.Chakraborty, V.Gourain, M.Benz, J.M.Scheiger, P.A.Levkin, A.A.Popova Materials Today Bio, 2021, 11(100112) Liquid Wells as Self-Healing, Functional Analogues to Solid Vessels Johannes M. Scheiger, Mariia A. Kuzina, Michael Eigenbrod, Yanchen Wu, Fei Wang, Stefan Heißler, Steffen Hardt, Britta Nestler, Pavel A. Levkin Advanced Materials, 2021, 33(2100117) High-throughput screening of multifunctional nanocoatings based on combinations of polyphenols and catecholamines Farid Behboodi-Sadabad, Shuai Li, Wenxi Lei, Yanxi Liu, Timo Sommer, Pascal Friederich, Caroline Sobek, Phillip B. Messersmith, Pavel A. Levkin Materials Today Bio, 2021, 10(100108) Fast Nanoliter‐Scale Cell Assays Using Droplet Microarray–Mass Spectrometry Imaging Carina RamalloGuevara, Dorothea Paulssen, Anna A. Popova, Carsten Hopf, Pavel A. Levkin Advanced Biology, 2021, 5(3) Fabrication of Quasi‐2D Shape‐Tailored Microparticles using Wettability Contrast‐Based Platforms Mafalda D. Neto, Aukha Stoppa, Miguel A. Neto, Filipe J. Oliveira, Maria C. Gomes, Aldo R. Boccaccini, Pavel A. Levkin, Mariana B. Oliveira, João F. Mano Advanced Materials, 2021, 33(14) 3D printing of inherently nanoporous polymers via polymerization-induced phase separation Zheqin Dong, Haijun Cui, Haodong Zhang, Fei Wang, Xiang Zhan, Frederik Mayer, Britta Nestler, Martin Wegener & Pavel A. Levkin Nature Communications, 2021, 12(247)