都书博 - 大连理工大学 - 生物工程学院

个人简介

教育经历 2006.92008.11 东北师范大学附属中学\ 2010.82014.6 新加坡南洋理工大学化学与生物化学学士 2014.82019.1 新加坡国立大学化学与生物化学博士工作经历 2018.112021.11 新加坡国立大学（新加坡）博士后研究员 2022.6至今大连理工大学生物工程学院副教授

研究领域

主要研究生物分子靶向控释，紧紧围绕新型疫苗和抗体药物开发、癌细胞检测及治疗的关键科学问题，对抗体药物的细胞内递送及对肿瘤的抑制和探索肿瘤细胞蛋白质组学等开展了研究工作

近期论文

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Zhang, B., Brahma, K. R., Zhu, L., Feng, J., Hu, S., Qian, L., Du, S.*; Yao, S. Q.*, Ge, J.*, Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins. J. Am. Chem. Soc. 2023, 145, 24272-24283. Qian, L.*; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.*; Ge, J.; Zeng, S.; Yao, S. Q.*, The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics. Chemical Reviews 2023, 123, 7782-7853. Du, W.#; Du, S.#; Dong, X.#; Bai, H.; Jiang, J.; Hao, S.; Yang, F.; Xiao, Q.; Zhang, B.; Ge, J.; Gao, L.; Li, L.*; Yao, S. Q.*; Huang, W.*, Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials 2023, 294, 122000. (#共同一作) Ge, J.; Du, S.*; Yao, S. Q.*, Bifunctional Lipid-Derived Affinity-Based Probes (AfBPs) for Analysis of Lipid–Protein Interactome. Accounts of Chemical Research 2022, 55 (24), 3663-3674. Xie, Y.#; Du, S.#; Liu, Z.; Liu, M.; Xu, Z.; Wang, X.; Kee, J. X.; Yi, F.*; Sun, H.*; Yao, S. Q.*, Chemical Biology Tools for Protein Lysine Acylation. Angew. Chem. Int. Ed. 2022.04, 61 (21), e202200303. (#共同一作) Du, S.; Liew, S. S.; Zhang, C-w.; Du, W.; Lang, W.; Yao, C. Y.; Li, L.; Ge, J.*; Yao, S. Q.*, Cell-Permeant Bioadaptors for Cytosolic Delivery of Native Antibodies: A “Mix-and-Go” Approach. ACS Cent. Sci. 2020.12, 6 (12), 2362–2376. Qu, Y.; Zhan, Q.; Du, S.*; Ding, Y.; Fang, B.; Du, W.; Wu, Q.*; Yu, H.; Li, L.*; Huang, W., Catalysis-based specific detection and inhibition of tyrosinase and their application. J. Pharm. Anal. 2020.10, 10 (5), 414-425. Du, S.; Liew, S. S.; Li, L.; Yao, S. Q.*, Bypassing endocytosis: direct cytosolic delivery of proteins. J. Am. Chem. Soc. 2018.11, 140 (47), 15986-15996. Du, S.; Wang, D.; Lee, J.-S.; Peng, B.; Ge, J.*; Yao, S. Q.*, Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues. Chem. Commun. 2017.08, 53 (60), 8443-8446.